Bulbourethral Gland Cysts in Three Mice.

Diseases of bulbourethral glands have rarely been reported in mice. The present report describes bulbourethral gland cysts in three male mice: a.1yearold DBA/2J mouse (case 1), a 10monthold nude mouse (case 2), and a 4.5monthold chimeric mouse (case 3). Round to oval fluctuant nodules were observed on their dorsal perineum. The nodules in cases 1 and 2 were pale, pink to tan, soft, and glistening; in case 3, the mass was purple-red and soft. All nodules were located subcutaneously between the bulbospongiosus and ischiocavernous muscles, with a deep connection to the urethra. The nodules were 13 mm (case 1), 6 mm (case 2), and 8 mm (case 3) in diameter. The cut surface of the nodules was cystic; the lumina were filled with clear gelatinous or viscous (cases 1 and 2) or thin blood-tinged fluid (case 3). The nodules comprised irregular cysts and acini that were lined by a single layer of cuboidal, pyramidal to tall columnar epithelial cells with little stroma. Bulbourethral gland cysts should be included as differential diagnoses for perineal nodules or swellings in mice.

Oropharyngeal Necrobacillosis with Septic Thrombophlebitis and Pulmonary Embolic Abscesses: Lemierre's Syndrome in a New Zealand White Rabbit.

Lemierre's syndrome, oropharyngeal infections induced by anaerobic bacteria, leading to fatal septic thrombophlebitis of the internal jugular vein and pulmonary embolic abscesses in humans, was diagnosed in a 6-month-old, male, New Zealand White rabbit. After acute onset of anorexia, lethargy, and depression, the rabbit died suddenly despite emergency clinical care. Necropsy revealed swelling, necrosis, and abscess in the soft tissues around the left caudal mandibular ramus, oral mucosa, and molar teeth, with systemic embolic abscesses and necrosis, especially in the jugular vein, lungs, and brain. Histologic examination revealed necrosis and embolic abscesses with filamentous bacteria in the mandibular soft tissues, salivary gland, jugular veins, alveolar bone and marrow, periodontal tissues and dental pulp, oral and pharyngeal mucosa, lungs, brain, liver, myocardium, meninges, and small intestine. Bacterial culture of the mandibular abscess and heart blood yielded Fusobacterium necrophorum.