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1.
Nat Rev Neurosci ; 23(7): 439-452, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35505255

RESUMO

Recent years have seen a blossoming of theories about the biological and physical basis of consciousness. Good theories guide empirical research, allowing us to interpret data, develop new experimental techniques and expand our capacity to manipulate the phenomenon of interest. Indeed, it is only when couched in terms of a theory that empirical discoveries can ultimately deliver a satisfying understanding of a phenomenon. However, in the case of consciousness, it is unclear how current theories relate to each other, or whether they can be empirically distinguished. To clarify this complicated landscape, we review four prominent theoretical approaches to consciousness: higher-order theories, global workspace theories, re-entry and predictive processing theories and integrated information theory. We describe the key characteristics of each approach by identifying which aspects of consciousness they propose to explain, what their neurobiological commitments are and what empirical data are adduced in their support. We consider how some prominent empirical debates might distinguish among these theories, and we outline three ways in which theories need to be developed to deliver a mature regimen of theory-testing in the neuroscience of consciousness. There are good reasons to think that the iterative development, testing and comparison of theories of consciousness will lead to a deeper understanding of this most profound of mysteries.


Assuntos
Estado de Consciência , Neurociências , Humanos
2.
PLoS Comput Biol ; 19(8): e1011280, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37531366

RESUMO

Predictive coding is an influential model of cortical neural activity. It proposes that perceptual beliefs are furnished by sequentially minimising "prediction errors"-the differences between predicted and observed data. Implicit in this proposal is the idea that successful perception requires multiple cycles of neural activity. This is at odds with evidence that several aspects of visual perception-including complex forms of object recognition-arise from an initial "feedforward sweep" that occurs on fast timescales which preclude substantial recurrent activity. Here, we propose that the feedforward sweep can be understood as performing amortized inference (applying a learned function that maps directly from data to beliefs) and recurrent processing can be understood as performing iterative inference (sequentially updating neural activity in order to improve the accuracy of beliefs). We propose a hybrid predictive coding network that combines both iterative and amortized inference in a principled manner by describing both in terms of a dual optimization of a single objective function. We show that the resulting scheme can be implemented in a biologically plausible neural architecture that approximates Bayesian inference utilising local Hebbian update rules. We demonstrate that our hybrid predictive coding model combines the benefits of both amortized and iterative inference-obtaining rapid and computationally cheap perceptual inference for familiar data while maintaining the context-sensitivity, precision, and sample efficiency of iterative inference schemes. Moreover, we show how our model is inherently sensitive to its uncertainty and adaptively balances iterative and amortized inference to obtain accurate beliefs using minimum computational expense. Hybrid predictive coding offers a new perspective on the functional relevance of the feedforward and recurrent activity observed during visual perception and offers novel insights into distinct aspects of visual phenomenology.


Assuntos
Aprendizagem , Percepção Visual , Teorema de Bayes
3.
PLoS Comput Biol ; 18(7): e1010223, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35797365

RESUMO

Human experience of time exhibits systematic, context-dependent deviations from clock time; for example, time is experienced differently at work than on holiday. Here we test the proposal that differences from clock time in subjective experience of time arise because time estimates are constructed by accumulating the same quantity that guides perception: salient events. Healthy human participants watched naturalistic, silent videos of up to 24 seconds in duration and estimated their duration while fMRI was acquired. We were able to reconstruct trial-by-trial biases in participants' duration reports, which reflect subjective experience of duration, purely from salient events in their visual cortex BOLD activity. By contrast, salient events in neither of two control regions-auditory and somatosensory cortex-were predictive of duration biases. These results held despite being able to (trivially) predict clock time from all three brain areas. Our results reveal that the information arising during perceptual processing of a dynamic environment provides a sufficient basis for reconstructing human subjective time duration.


Assuntos
Córtex Visual , Encéfalo , Mapeamento Encefálico , Humanos , Imageamento por Ressonância Magnética/métodos , Tempo
4.
Neuroimage ; 263: 119624, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36108798

RESUMO

Schizophrenia and states induced by certain psychotomimetic drugs may share some physiological and phenomenological properties, but they differ in fundamental ways: one is a crippling chronic mental disease, while the others are temporary, pharmacologically-induced states presently being explored as treatments for mental illnesses. Building towards a deeper understanding of these different alterations of normal consciousness, here we compare the changes in neural dynamics induced by LSD and ketamine (in healthy volunteers) against those associated with schizophrenia, as observed in resting-state M/EEG recordings. While both conditions exhibit increased neural signal diversity, our findings reveal that this is accompanied by an increased transfer entropy from the front to the back of the brain in schizophrenia, versus an overall reduction under the two drugs. Furthermore, we show that these effects can be reproduced via different alterations of standard Bayesian inference applied on a computational model based on the predictive processing framework. In particular, the effects observed under the drugs are modelled as a reduction of the precision of the priors, while the effects of schizophrenia correspond to an increased precision of sensory information. These findings shed new light on the similarities and differences between schizophrenia and two psychotomimetic drug states, and have potential implications for the study of consciousness and future mental health treatments.


Assuntos
Alucinógenos , Ketamina , Esquizofrenia , Humanos , Alucinógenos/farmacologia , Esquizofrenia/tratamento farmacológico , Teorema de Bayes , Encéfalo/fisiologia , Ketamina/farmacologia
5.
Neural Comput ; 34(7): 1501-1544, 2022 06 16.
Artigo em Inglês | MEDLINE | ID: mdl-35671462

RESUMO

Human perception and experience of time are strongly influenced by ongoing stimulation, memory of past experiences, and required task context. When paying attention to time, time experience seems to expand; when distracted, it seems to contract. When considering time based on memory, the experience may be different than what is in the moment, exemplified by sayings like "time flies when you're having fun." Experience of time also depends on the content of perceptual experience-rapidly changing or complex perceptual scenes seem longer in duration than less dynamic ones. The complexity of interactions among attention, memory, and perceptual stimulation is a likely reason that an overarching theory of time perception has been difficult to achieve. Here, we introduce a model of perceptual processing and episodic memory that makes use of hierarchical predictive coding, short-term plasticity, spatiotemporal attention, and episodic memory formation and recall, and apply this model to the problem of human time perception. In an experiment with approximately 13,000 human participants, we investigated the effects of memory, cognitive load, and stimulus content on duration reports of dynamic natural scenes up to about 1 minute long. Using our model to generate duration estimates, we compared human and model performance. Model-based estimates replicated key qualitative biases, including differences by cognitive load (attention), scene type (stimulation), and whether the judgment was made based on current or remembered experience (memory). Our work provides a comprehensive model of human time perception and a foundation for exploring the computational basis of episodic memory within a hierarchical predictive coding framework.


Assuntos
Memória Episódica , Percepção do Tempo , Humanos , Rememoração Mental , Tempo
6.
Philos Trans A Math Phys Eng Sci ; 380(2227): 20210246, 2022 Jul 11.
Artigo em Inglês | MEDLINE | ID: mdl-35599558

RESUMO

Emergence is a profound subject that straddles many scientific disciplines, including the formation of galaxies and how consciousness arises from the collective activity of neurons. Despite the broad interest that exists on this concept, the study of emergence has suffered from a lack of formalisms that could be used to guide discussions and advance theories. Here, we summarize, elaborate on, and extend a recent formal theory of causal emergence based on information decomposition, which is quantifiable and amenable to empirical testing. This theory relates emergence with information about a system's temporal evolution that cannot be obtained from the parts of the system separately. This article provides an accessible but rigorous introduction to the framework, discussing the merits of the approach in various scenarios of interest. We also discuss several interpretation issues and potential misunderstandings, while highlighting the distinctive benefits of this formalism. This article is part of the theme issue 'Emergent phenomena in complex physical and socio-technical systems: from cells to societies'.


Assuntos
Estado de Consciência , Modelos Teóricos , Neurônios , Causalidade , Estado de Consciência/fisiologia , Neurônios/fisiologia
7.
PLoS Comput Biol ; 16(4): e1007805, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32324758

RESUMO

Converging theories suggest that organisms learn and exploit probabilistic models of their environment. However, it remains unclear how such models can be learned in practice. The open-ended complexity of natural environments means that it is generally infeasible for organisms to model their environment comprehensively. Alternatively, action-oriented models attempt to encode a parsimonious representation of adaptive agent-environment interactions. One approach to learning action-oriented models is to learn online in the presence of goal-directed behaviours. This constrains an agent to behaviourally relevant trajectories, reducing the diversity of the data a model need account for. Unfortunately, this approach can cause models to prematurely converge to sub-optimal solutions, through a process we refer to as a bad-bootstrap. Here, we exploit the normative framework of active inference to show that efficient action-oriented models can be learned by balancing goal-oriented and epistemic (information-seeking) behaviours in a principled manner. We illustrate our approach using a simple agent-based model of bacterial chemotaxis. We first demonstrate that learning via goal-directed behaviour indeed constrains models to behaviorally relevant aspects of the environment, but that this approach is prone to sub-optimal convergence. We then demonstrate that epistemic behaviours facilitate the construction of accurate and comprehensive models, but that these models are not tailored to any specific behavioural niche and are therefore less efficient in their use of data. Finally, we show that active inference agents learn models that are parsimonious, tailored to action, and which avoid bad bootstraps and sub-optimal convergence. Critically, our results indicate that models learned through active inference can support adaptive behaviour in spite of, and indeed because of, their departure from veridical representations of the environment. Our approach provides a principled method for learning adaptive models from limited interactions with an environment, highlighting a route to sample efficient learning algorithms.


Assuntos
Biologia Computacional/métodos , Meio Ambiente , Modelos Biológicos , Algoritmos , Fenômenos Fisiológicos Bacterianos , Quimiotaxia/fisiologia , Objetivos , Aprendizagem
8.
PLoS Comput Biol ; 16(12): e1008289, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33347467

RESUMO

The broad concept of emergence is instrumental in various of the most challenging open scientific questions-yet, few quantitative theories of what constitutes emergent phenomena have been proposed. This article introduces a formal theory of causal emergence in multivariate systems, which studies the relationship between the dynamics of parts of a system and macroscopic features of interest. Our theory provides a quantitative definition of downward causation, and introduces a complementary modality of emergent behaviour-which we refer to as causal decoupling. Moreover, the theory allows practical criteria that can be efficiently calculated in large systems, making our framework applicable in a range of scenarios of practical interest. We illustrate our findings in a number of case studies, including Conway's Game of Life, Reynolds' flocking model, and neural activity as measured by electrocorticography.


Assuntos
Simulação por Computador , Teoria da Informação , Modelos Biológicos , Animais , Comportamento Animal , Aves , Causalidade , Biologia Computacional , Haplorrinos , Humanos , Modelos Estatísticos , Análise Multivariada , Neurofisiologia
9.
Neuroimage ; 209: 116462, 2020 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-31857204

RESUMO

Neuroimaging studies of the psychedelic state offer a unique window onto the neural basis of conscious perception and selfhood. Despite well understood pharmacological mechanisms of action, the large-scale changes in neural dynamics induced by psychedelic compounds remain poorly understood. Using source-localised, steady-state MEG recordings, we describe changes in functional connectivity following the controlled administration of LSD, psilocybin and low-dose ketamine, as well as, for comparison, the (non-psychedelic) anticonvulsant drug tiagabine. We compare both undirected and directed measures of functional connectivity between placebo and drug conditions. We observe a general decrease in directed functional connectivity for all three psychedelics, as measured by Granger causality, throughout the brain. These data support the view that the psychedelic state involves a breakdown in patterns of functional organisation or information flow in the brain. In the case of LSD, the decrease in directed functional connectivity is coupled with an increase in undirected functional connectivity, which we measure using correlation and coherence. This surprising opposite movement of directed and undirected measures is of more general interest for functional connectivity analyses, which we interpret using analytical modelling. Overall, our results uncover the neural dynamics of information flow in the psychedelic state, and highlight the importance of comparing multiple measures of functional connectivity when analysing time-resolved neuroimaging data.


Assuntos
Córtex Cerebral/efeitos dos fármacos , Conectoma , Alucinógenos/farmacologia , Ketamina/farmacologia , Dietilamida do Ácido Lisérgico/farmacologia , Magnetoencefalografia/efeitos dos fármacos , Rede Nervosa/efeitos dos fármacos , Psilocibina/farmacologia , Adulto , Anticonvulsivantes/farmacologia , Córtex Cerebral/fisiologia , Feminino , Alucinógenos/administração & dosagem , Humanos , Ketamina/administração & dosagem , Dietilamida do Ácido Lisérgico/administração & dosagem , Masculino , Rede Nervosa/fisiologia , Psilocibina/administração & dosagem , Tiagabina/farmacologia , Adulto Jovem
10.
Conscious Cogn ; 85: 102989, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32950723

RESUMO

Prior knowledge has been shown to facilitate the incorporation of visual stimuli into awareness. We adopted an individual differences approach to explore whether a tendency to 'see the expected' is general or method-specific. We administered a binocular rivalry task and manipulated selective attention, as well as induced expectations via predictive context, self-generated imagery, expectancy cues, and perceptual priming. Most prior manipulations led to a facilitated awareness of the biased percept in binocular rivalry, whereas strong signal primes led to a suppressed awareness, i.e., adaptation. Correlations and factor analysis revealed that the facilitatory effect of priors on visual awareness is closely related to attentional control. We also investigated whether expectation-based biases predict perceptual abilities. Adaptation to strong primes predicted improved naturalistic change detection and the facilitatory effect of weak primes predicted the experience of perceptual anomalies. Taken together, our results indicate that the facilitatory effect of priors may be underpinned by an attentional mechanism but the tendency to 'see the expected' is method-specific.


Assuntos
Individualidade , Visão Binocular , Adaptação Fisiológica , Atenção , Sinais (Psicologia) , Humanos , Estimulação Luminosa , Percepção Visual
11.
Mem Cognit ; 48(2): 188-199, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31939042

RESUMO

Researchers often adjudicate between models of memory according to the models' ability to explain impaired patterns of performance (e.g., in amnesia). In contrast, evidence from special groups with enhanced memory is very rarely considered. Here, we explored how people with unusual perceptual experiences (synaesthesia) perform on various measures of memory and test how computational models of memory may account for their enhanced performance. We contrasted direct and indirect measures of memory (i.e., recognition memory, repetition priming, and fluency) in grapheme-colour synaesthetes and controls using a continuous identification with recognition (CID-R) paradigm. Synaesthetes outperformed controls on recognition memory and showed a different reaction-time pattern for identification. The data were most parsimoniously accounted for by a single-system computational model of the relationship between recognition and identification. Overall, the findings speak in favour of enhanced processing as an explanation for the memory advantage in synaesthesia. In general, our results show how synaesthesia can be used as an effective tool to study how individual differences in perception affect cognitive functions.


Assuntos
Percepção de Cores/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Reconhecimento Psicológico/fisiologia , Priming de Repetição/fisiologia , Sinestesia/fisiopatologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Leitura , Adulto Jovem
12.
J Neurol Neurosurg Psychiatry ; 90(4): 404-411, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30361295

RESUMO

BACKGROUND: Corticospinal tract (CST) degeneration and cortical atrophy are consistent features of amyotrophic lateral sclerosis (ALS). We hypothesised that neurite orientation dispersion and density imaging (NODDI), a multicompartment model of diffusion MRI, would reveal microstructural changes associated with ALS within the CST and precentral gyrus (PCG) 'in vivo'. METHODS: 23 participants with sporadic ALS and 23 healthy controls underwent diffusion MRI. Neurite density index (NDI), orientation dispersion index (ODI) and free water fraction (isotropic compartment (ISO)) were derived. Whole brain voxel-wise analysis was performed to assess for group differences. Standard diffusion tensor imaging (DTI) parameters were computed for comparison. Subgroup analysis was performed to investigate for NODDI parameter differences relating to bulbar involvement. Correlation of NODDI parameters with clinical variables were also explored. The results were accepted as significant where p<0.05 after family-wise error correction at the cluster level, clusters formed with p<0.001. RESULTS: In the ALS group NDI was reduced in the extensive regions of the CST, the corpus callosum and the right PCG. ODI was reduced in the right anterior internal capsule and the right PCG. Significant differences in NDI were detected between subgroups stratified according to the presence or absence of bulbar involvement. ODI and ISO correlated with disease duration. CONCLUSIONS: NODDI demonstrates that axonal loss within the CST is a core feature of degeneration in ALS. This is the main factor contributing to the altered diffusivity profile detected using DTI. NODDI also identified dendritic alterations within the PCG, suggesting microstructural cortical dendritic changes occur together with CST axonal damage.


Assuntos
Esclerose Lateral Amiotrófica/diagnóstico por imagem , Axônios/patologia , Lobo Frontal/diagnóstico por imagem , Neuritos/patologia , Tratos Piramidais/diagnóstico por imagem , Idoso , Estudos de Casos e Controles , Córtex Cerebral/diagnóstico por imagem , Imagem de Difusão por Ressonância Magnética , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
13.
Psychol Sci ; 30(6): 842-853, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31023161

RESUMO

The experience of authorship over one's actions and their consequences-sense of agency-is a fundamental aspect of conscious experience. In recent years, it has become common to use intentional binding as an implicit measure of the sense of agency. However, it remains contentious whether reported intentional-binding effects indicate the role of intention-related information in perception or merely represent a strong case of multisensory causal binding. Here, we used a novel virtual-reality setup to demonstrate identical magnitude-binding effects in both the presence and complete absence of intentional action, when perceptual stimuli were matched for temporal and spatial information. Our results demonstrate that intentional-binding-like effects are most simply accounted for by multisensory causal binding without necessarily being related to intention or agency. Future studies that relate binding effects to agency must provide evidence for effects beyond that expected for multisensory causal binding by itself.


Assuntos
Conscientização , Intenção , Desempenho Psicomotor , Percepção do Tempo , Adulto , Comportamento Cooperativo , Feminino , Humanos , Julgamento , Masculino , Adulto Jovem
14.
Brain ; 141(11): 3249-3261, 2018 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-30346484

RESUMO

Tourette syndrome is a neurodevelopmental disorder, characterized by motor and phonic tics. Tics are typically experienced as avolitional, compulsive, and associated with premonitory urges. They are exacerbated by stress and can be triggered by external stimuli, including social cues like the actions and facial expressions of others. Importantly, emotional social stimuli, with angry facial stimuli potentially the most potent social threat cue, also trigger behavioural reactions in healthy individuals, suggesting that such mechanisms may be particularly sensitive in people with Tourette syndrome. Twenty-one participants with Tourette syndrome and 21 healthy controls underwent functional MRI while viewing faces wearing either neutral or angry expressions to quantify group differences in neural activity associated with processing social information. Simultaneous video recordings of participants during neuroimaging enabled us to model confounding effects of tics on task-related responses to the processing of faces. In both Tourette syndrome and control participants, face stimuli evoked enhanced activation within canonical face perception regions, including the occipital face area and fusiform face area. However, the Tourette syndrome group showed additional responses within the anterior insula to both neutral and angry faces. Functional connectivity during face viewing was then examined in a series of psychophysiological interactions. In participants with Tourette syndrome, the insula showed functional connectivity with a set of cortical regions previously implicated in tic generation: the presupplementary motor area, premotor cortex, primary motor cortex, and the putamen. Furthermore, insula functional connectivity with the globus pallidus and thalamus varied in proportion to tic severity, while supplementary motor area connectivity varied in proportion to premonitory sensations, with insula connectivity to these regions increasing to a greater extent in patients with worse symptom severity. In addition, the occipital face area showed increased functional connectivity in Tourette syndrome participants with posterior cortical regions, including primary somatosensory cortex, and occipital face area connectivity with primary somatosensory and primary motor cortices varied in proportion to tic severity. There were no significant psychophysiological interactions in controls. These findings highlight a potential mechanism in Tourette syndrome through which heightened representation within insular cortex of embodied affective social information may impact the reactivity of subcortical motor pathways, supporting programmed motor actions that are causally implicated in tic generation. Medicinal and psychological therapies that focus on reducing insular hyper-reactivity to social stimuli may have potential benefit for tic reduction in people with Tourette syndrome.


Assuntos
Encéfalo/diagnóstico por imagem , Reconhecimento Facial/fisiologia , Córtex Motor/diagnóstico por imagem , Síndrome de Tourette/patologia , Síndrome de Tourette/fisiopatologia , Adolescente , Adulto , Encéfalo/patologia , Mapeamento Encefálico , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Modelos Lineares , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Psicofisiologia , Síndrome de Tourette/diagnóstico por imagem , Adulto Jovem
15.
J Neurosci ; 37(35): 8486-8497, 2017 08 30.
Artigo em Inglês | MEDLINE | ID: mdl-28765331

RESUMO

A novel neural signature of active visual processing has recently been described in the form of the "perceptual echo", in which the cross-correlation between a sequence of randomly fluctuating luminance values and occipital electrophysiological signals exhibits a long-lasting periodic (∼100 ms cycle) reverberation of the input stimulus (VanRullen and Macdonald, 2012). As yet, however, the mechanisms underlying the perceptual echo and its function remain unknown. Reasoning that natural visual signals often contain temporally predictable, though nonperiodic features, we hypothesized that the perceptual echo may reflect a periodic process associated with regularity learning. To test this hypothesis, we presented subjects with successive repetitions of a rapid nonperiodic luminance sequence, and examined the effects on the perceptual echo, finding that echo amplitude linearly increased with the number of presentations of a given luminance sequence. These data suggest that the perceptual echo reflects a neural signature of regularity learning.Furthermore, when a set of repeated sequences was followed by a sequence with inverted luminance polarities, the echo amplitude decreased to the same level evoked by a novel stimulus sequence. Crucially, when the original stimulus sequence was re-presented, the echo amplitude returned to a level consistent with the number of presentations of this sequence, indicating that the visual system retained sequence-specific information, for many seconds, even in the presence of intervening visual input. Altogether, our results reveal a previously undiscovered regularity learning mechanism within the human visual system, reflected by the perceptual echo.SIGNIFICANCE STATEMENT How the brain encodes and learns fast-changing but nonperiodic visual input remains unknown, even though such visual input characterizes natural scenes. We investigated whether the phenomenon of "perceptual echo" might index such learning. The perceptual echo is a long-lasting reverberation between a rapidly changing visual input and evoked neural activity, apparent in cross-correlations between occipital EEG and stimulus sequences, peaking in the alpha (∼10 Hz) range. We indeed found that perceptual echo is enhanced by repeatedly presenting the same visual sequence, indicating that the human visual system can rapidly and automatically learn regularities embedded within fast-changing dynamic sequences. These results point to a previously undiscovered regularity learning mechanism, operating at a rate defined by the alpha frequency.


Assuntos
Aprendizagem/fisiologia , Potenciação de Longa Duração/fisiologia , Rede Nervosa/fisiologia , Estimulação Luminosa , Córtex Visual/fisiologia , Percepção Visual/fisiologia , Adolescente , Adulto , Atenção/fisiologia , Feminino , Humanos , Masculino , Adulto Jovem
16.
Neuroimage ; 178: 744-748, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29883736

RESUMO

Granger-Geweke causality (GGC) is a powerful and popular method for identifying directed functional ('causal') connectivity in neuroscience. In a recent paper, Stokes and Purdon (2017b) raise several concerns about its use. They make two primary claims: (1) that GGC estimates may be severely biased or of high variance, and (2) that GGC fails to reveal the full structural/causal mechanisms of a system. However, these claims rest, respectively, on an incomplete evaluation of the literature, and a misconception about what GGC can be said to measure. Here we explain how existing approaches resolve the first issue, and discuss the frequently-misunderstood distinction between functional and effective neural connectivity which underlies Stokes and Purdon's second claim.


Assuntos
Neurociências , Descanso
17.
Neuroimage ; 167: 130-142, 2018 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-29162522

RESUMO

Loss of consciousness can result from a wide range of causes, including natural sleep and pharmacologically induced anesthesia. Important insights might thus come from identifying neuronal mechanisms of loss and re-emergence of consciousness independent of a specific manipulation. Therefore, to seek neuronal signatures of loss of consciousness common to sleep and anesthesia we analyzed spontaneous electrophysiological activity recorded in two experiments. First, electrocorticography (ECoG) acquired from 4 macaque monkeys anesthetized with different anesthetic agents (ketamine, medetomidine, propofol) and, second, stereo-electroencephalography (sEEG) from 10 epilepsy patients in different wake-sleep stages (wakefulness, NREM, REM). Specifically, we investigated co-activation patterns among brain areas, defined as correlations between local amplitudes of gamma-band activity. We found that resting wakefulness was associated with intermediate levels of gamma-band coupling, indicating neither complete dependence, nor full independence among brain regions. In contrast, loss of consciousness during NREM sleep and propofol anesthesia was associated with excessively correlated brain activity, as indicated by a robust increase of number and strength of positive correlations. However, such excessively correlated brain signals were not observed during REM sleep, and were present only to a limited extent during ketamine anesthesia. This might be related to the fact that, despite suppression of behavioral responsiveness, REM sleep and ketamine anesthesia often involve presence of dream-like conscious experiences. We conclude that hyper-correlated gamma-band activity might be a signature of loss of consciousness common across various manipulations and independent of behavioral responsiveness.


Assuntos
Anestesia , Estado de Consciência/fisiologia , Eletrocorticografia/métodos , Sincronização de Fases em Eletroencefalografia/fisiologia , Ritmo Gama/fisiologia , Fases do Sono/fisiologia , Sono/fisiologia , Vigília/fisiologia , Adulto , Anestésicos Gerais/farmacologia , Animais , Humanos , Ketamina/farmacologia , Macaca , Medetomidina/farmacologia , Propofol/farmacologia
18.
Conscious Cogn ; 65: 334-341, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30072110

RESUMO

Does disruption of prefrontal cortical activity using transcranial magnetic stimulation (TMS) impair visual metacognition? An initial study supporting this idea (Rounis, Maniscalco, Rothwell, Passingham, & Lau, 2010) motivated an attempted replication and extension (Bor, Schwartzman, Barrett, & Seth, 2017). Bor et al. failed to replicate the initial study, concluding that there was not good evidence that TMS to dorsolateral prefrontal cortex impairs visual metacognition. This failed replication has recently been critiqued by some of the authors of the initial study (Ruby, Maniscalco, & Peters, 2018). Here we argue that these criticisms are misplaced. In our response, we encounter some more general issues concerning good practice in replication of cognitive neuroscience studies, and in setting criteria for excluding data when employing statistical analyses like signal detection theory. We look forward to further studies investigating the role of prefrontal cortex in metacognition, with increasingly refined methodologies, motivated by the discussions in this series of papers.


Assuntos
Metacognição , Estimulação Magnética Transcraniana , Estado de Consciência , Humanos , Córtex Pré-Frontal
19.
Cogn Neuropsychiatry ; 23(3): 165-179, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29485348

RESUMO

INTRODUCTION: Metacognition, or "thinking about thinking", is a higher-order thought process that allows for the evaluation of perceptual processes for accuracy. Metacognitive accuracy is associated with the grey matter volume (GMV) in the prefrontal cortex (PFC), an area also impacted in schizophrenia. The present study set out to investigate whether deficits in metacognitive accuracy are present in the early stages of psychosis. METHODS: Metacognitive accuracy in first-episode psychosis (FEP) was assessed on a perceptual decision-making task and their performance compared to matched healthy control participants (N = 18). A novel signal detection theory approach was used to model metacognitive sensitivity independently from objective perceptual performance. A voxel-based morphometry investigation was also conducted on GMV. RESULTS: We found that the FEP group demonstrated significantly worse metacognitive accuracy compared to controls (p = .039). Importantly, GMV deficits were also observed in the superior frontal gyrus. The findings suggest a specific deficit in this processing domain to exist at first episode; however, no relationship was found between GMV and metacognitive accuracy. CONCLUSIONS: Our findings support the notion that an inability to accurately scrutinise perception may underpin functional deficits observed in later schizophrenia; however, the exact neural basis of metacognitive deficits in FEP remains elusive.


Assuntos
Substância Cinzenta/diagnóstico por imagem , Metacognição , Córtex Pré-Frontal/diagnóstico por imagem , Transtornos Psicóticos/diagnóstico por imagem , Adolescente , Adulto , Estudos de Casos e Controles , Tomada de Decisões , Feminino , Substância Cinzenta/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Tamanho do Órgão , Córtex Pré-Frontal/patologia , Transtornos Psicóticos/psicologia , Esquizofrenia/diagnóstico por imagem , Psicologia do Esquizofrênico , Adulto Jovem
20.
Proc Natl Acad Sci U S A ; 112(21): E2820-8, 2015 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-25964365

RESUMO

In vivo tractography based on diffusion magnetic resonance imaging (dMRI) has opened new doors to study structure-function relationships in the human brain. Initially developed to map the trajectory of major white matter tracts, dMRI is used increasingly to infer long-range anatomical connections of the cortex. Because axonal projections originate and terminate in the gray matter but travel mainly through the deep white matter, the success of tractography hinges on the capacity to follow fibers across this transition. Here we demonstrate that the complex arrangement of white matter fibers residing just under the cortical sheet poses severe challenges for long-range tractography over roughly half of the brain. We investigate this issue by comparing dMRI from very-high-resolution ex vivo macaque brain specimens with histological analysis of the same tissue. Using probabilistic tracking from pure gray and white matter seeds, we found that ∼50% of the cortical surface was effectively inaccessible for long-range diffusion tracking because of dense white matter zones just beneath the infragranular layers of the cortex. Analysis of the corresponding myelin-stained sections revealed that these zones colocalized with dense and uniform sheets of axons running mostly parallel to the cortical surface, most often in sulcal regions but also in many gyral crowns. Tracer injection into the sulcal cortex demonstrated that at least some axonal fibers pass directly through these fiber systems. Current and future high-resolution dMRI studies of the human brain will need to develop methods to overcome the challenges posed by superficial white matter systems to determine long-range anatomical connections accurately.


Assuntos
Imagem de Tensor de Difusão/métodos , Macaca mulatta/anatomia & histologia , Substância Branca/anatomia & histologia , Animais , Córtex Cerebral/anatomia & histologia , Conectoma/métodos , Conectoma/estatística & dados numéricos , Bases de Dados Factuais , Imagem de Tensor de Difusão/estatística & dados numéricos , Substância Cinzenta/anatomia & histologia , Humanos , Imageamento Tridimensional , Masculino , Modelos Neurológicos , Vias Neurais/anatomia & histologia
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