RESUMO
The depletion of the granules of argyrophile cells following administration of reserpine has been studied at various levels of the gastrointestinal tract of the Rhesus monkey. Granulation of the cells has been estimated by the photometric method of SINGH(1976). The argyrophile cells that persist after reserpine administration show a statistically significant reduction in their granulation as compared to cells of untreated controls (P less than 0.001).
Assuntos
Sistema Cromafim/efeitos dos fármacos , Sistema Digestório/citologia , Células Enterocromafins/efeitos dos fármacos , Reserpina/farmacologia , Animais , Grânulos Cromafim/efeitos dos fármacos , Feminino , Haplorrinos , Macaca mulatta , Masculino , Fotometria/métodosRESUMO
The influence of reserpine (5 mg/kg) on the argentaffin and argyrophile cells has been studied in 4 monkeys, and in 4 controls. In the treated animals, there is a marked and obvious reduction in the number of argentaffin cells; the cells that remain also show signs of partial depletion. Reduction of the number of argyrophile cells is not obvious on casual examination, but cell counts reveal a statistically significant reduction. The persisting argyrophile cells show signs of partial depletion.