1.
Org Lett
; 3(19): 3021-3, 2001 Sep 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11554833
RESUMO
Both enantiomers of imperanene, a platelet aggregation inhibitor, have been synthesized in 82-90% ee. The key step of establishing the chiral center was achieved through stereoselective alkylation with benzyl chloromethyl ether using Enders' RAMP/SAMP chiral auxiliary method. The natural product was determined to be the (S)-enantiomer through comparison of optical rotation data. Reaction: see text.