Accuracy of computer-aided image analysis in the diagnosis of odontogenic cysts: A systematic review.

BACKGROUND: This study aimed to search for scientific evidence concerning the accuracy of computer-assisted analysis for diagnosing odontogenic cysts. MATERIAL AND METHODS: A systematic review was conducted according to the PRISMA statements and considering eleven databases, including the grey literature. Protocol was registered in PROSPERO (CRD [Blinding]). The PECO strategy was used to define the eligibility criteria and only studies involving diagnostic accuracy were included. Their risk of bias was investigated using the Joanna Briggs Institute Critical Appraisal tool. RESULTS: Out of 437 identified citations, five papers, published between 2006 and 2019, fulfilled the criteria and were included in this systematic review. A total of 5,264 images from 508 lesions, classified as radicular cyst, odontogenic keratocyst, lateral periodontal cyst, glandular odontogenic cyst, or dentigerous cyst, were analyzed. All selected articles scored low risk of bias. In three studies, the best performances were achieved when the two subtypes of odontogenic keratocysts (solitary or syndromic) were pooled together, the case-wise analysis showing a success rate of 100% for odontogenic keratocysts and radicular cysts, in one of them. In two studies, the dentigerous cyst was associated with the majority of misclassifications, and its omission from the dataset improved significantly the classification rates. CONCLUSIONS: The overall evaluation showed all studies presented high accuracy rates of computer-aided systems in classifying odontogenic cysts in digital images of histological tissue sections. However, due to the heterogeneity of the studies, a meta-analysis evaluating the outcomes of interest was not performed and a pragmatic recommendation about their use is not possible.

Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate.

Iron accumulation in the brain has been associated to the pathogenesis of neurodegenerative disorders. We have previously demonstrated that iron overload in the neonatal period results in severe and persistent memory deficits in adult rats. Alterations in histone acetylation have been associated with memory deficits in models of neurological disorders. Here we examine histone acetylation in the brain and the effects of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) on memory in the neonatal iron overload model in rats. Rats received vehicle or 30.0-mg/kg Fe⁺² orally at postnatal days 12-14. When animals reached adulthood, they were given training in either novel object recognition or inhibitory avoidance. Histone acetylation in the dorsal hippocampus and the effects of NaB were examined in separate sets of rats. Iron overload led to a reduction in H3 lysine 9 acetylation in the hippocampus, without affecting the acetylation of other H3 and H4 lysine residues. A single systemic injection of NaB (1.2 g/kg) immediately after training ameliorated iron-induced memory impairments. The results suggest that a reduction in H3K9 acetylation might play a role in iron-induced memory impairment and support the view that HDACis can rescue memory dysfunction in models of brain disorders.

Desempenho e rendimento de carcaça de frangos de corte alimentados com pectina na ração / Performance and carcass yield of broiler chickens fed with pectin in the ration

Avaliou-se o efeito da ingestão contínua de pectina em 720 frangos de corte sobre o desempenho e rendimento de carcaça e o consumo de água. O delineamento foi inteiramente ao acaso, em esquema de parcela subdividida, com níveis de pectina 0, 1, 3 e 5%, e idade primeira, segunda, terceira, quarta, quinta e sexta semanas, com seis repetições por tratamento. A viabilidade criatória não foi influenciada pela pectina na ração. O peso vivo, o consumo de ração e o ganho de peso diminuíram, e a conversão alimentar aumentou com a ingestão de pectina aos 35 e 42 dias. Não houve efeito da pectina sobre o consumo de ração (CR) e o consumo de água (CAg) na terceira semana. Na sexta semana, o CAg e a relação CAg:CR aumentaram com a ingestão de pectina. Aos 35e 42 dias, todos os parâmetros avaliados para rendimento de carcaça e corte diminuíram com o aumento da ingestão da fibra, sendo que apenas o rendimento de coxa+sobrecoxa não sofreu influência aos 42 dias. Os dados mostram que a ingestão contínua de até 1% de pectina na ração mantém o desempenho máximo das aves e que o consumo acima desse nível prejudica os parâmetros zootécnicos e aumenta o consumo de água na fase de maior crescimento.

The effect of the continuous intake of pectin was evaluated for 720 broilers regarding performance, carcass yield and water consumption. The design was completely randomized in a split plot design, with pectin levels of 0, 1, 3 and 5% and age 1st, 2nd, 3rd, 4th, 5th and 6th week, with six replicates. The viability was not influenced by dietary pectin. Body weight, feed intake and weight gain decreased and feed intake increased with pectin at 35 and 42 days. No effect of pectin on feed intake (FI) and water consumption (W) in the third week. On the sixth week regarding W and FI: W increased with the intake of pectin. At 35 and 42 days all parameters for carcass and cut decreased with increasing intake of fiber, and only the thigh + drumstick yield was not affected at 42 days. The data show that the continuous intake of up to 1% pectin in the diet maintains the best performance in birds and consumption above that level affects the performance parameters and increases the consumption of water in the higher growth phase.