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1.
Phys Chem Chem Phys ; 26(4): 3516-3524, 2024 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-38206350

RESUMO

Herein, a mesoporous MnCo2O4/Co3O4 nanocomposite was fabricated using a polyvinylpyrrolidone (PVP)-assisted hydrothermal synthesis method by maintaining only the non-stoichiometric ratio of Mn and Co (2 : 6), leading to an extra phase of Co3O4 coupled with MnCo2O4. Microstructural analysis showed that the obtained sample has a uniform nanowire-like morphology composed of interconnected nanoparticles. The stoichiometric ratio (2 : 4) was maintained to synthesize pure MnCo2O4 for comparative analysis. However, the obtained structure of pure MnCo2O4 was found to be irregular and fragile. After their employment as anode-active materials, the nanocomposite electrode showed superior high rate capability (1043.8 mA h g-1 at 5C) and long-term cycling stability (773.6 mA h g-1 after 500 cycles at 0.5C) in comparison to the pure MnCo2O4 electrode (771.5 mA h g-1 at 5C and 638.9 mA h g-1 at 0.5C after 500 cycles). It was believed that the extra phase of Co3O4 may also participate in the electrochemical reactions due to its high electrochemically active nature. Benefiting from the appealing architectural features and striking synergistic effect, the integrated MnCo2O4/Co3O4 nanocomposite anode exhibits excellent electrochemical properties and high cycle stability for LIBs.

2.
Phys Chem Chem Phys ; 26(17): 13152-13163, 2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38629633

RESUMO

The current work describes a facile synthesis of spinel-type ZnCo2O4 along with an additional phase, Co3O4, by simply maintaining a non-stoichiometric ratio of Zn and Co precursors. Pure ZnCo2O4 and Co3O4 were also synthesized using the same method to compare results. The obtained morphologies of samples show that small-sized nanoparticles are interconnected and form a porous nanosheet-like structure. When used as anode materials for Li-ion batteries, the ZnCo2O4/Co3O4 nanocomposite electrode exhibits a highly stable charge capacity of 1146.2 mA h g-1 at 0.5C after 350 cycles, which is superior to those of other two pure electrodes, which can be attributed to its optimum porosity, synergistic effect of ZnCo2O4 and Co3O4, increased active sites for Li+ ion diffusion, and higher electrical conductivity. Although the pure Co3O4 electrode displayed a much higher rate capability than the ZnCo2O4/Co3O4 nanocomposite electrode at all investigated current rates, the Co3O4 morphology apparently could not withstand long-term cycling, and the electrode became pulverized due to the repeated volume expansion/contraction, resulting in a rapid decrease in the capacity.

3.
Med Educ ; 57(1): 102-107, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-35837829

RESUMO

THE ISSUE: The shift to a more diverse workforce that includes physicians with disabilities has gained considerable international traction. Indeed, disability inclusion is experiencing a renaissance in medical education. However, the philosophy of disability inclusion must be adjusted from one where disabled trainees are viewed as problematic and having to 'overcome' disability to one where institutions anticipate and welcome disabled trainees as a normative part of a diverse community. OBSERVATIONS: Most trainees with disabilities will enter an unregulated, uninformed system leaving them vulnerable to under-accommodation, systems barriers and lack of informed support. Further, the perception of the super human good doctor creates disincentives for candidates to disclose their disability, creating structural barriers that the system needs to address. A less often discussed contributor to health care inequities is the inadequate training of health professional educators on disability rights and disability competencies. Indeed, the lack of education, coupled with minimal exposure to disability outside of the hierarchical patient-provider relationship, perpetuates to stereotypes and biases that impact clinical care. APPROACH: Disability inclusion has not been reviewed through the lens of quality improvement. To close this gap, we examine the state of the science through the lens of disability inclusion and offer considerations for a quality improvement approach in medical education that addresses the global revised trilogy of World Federation for Medical Education standards of quality improvement at all three levels of education, training and practice. CONCLUSION: We propose a vision of systems-based disability-inclusive, accessible and equitable medical education using 9 of Deming's 14 points as applicable to medical education.


Assuntos
Educação Médica , Melhoria de Qualidade , Humanos
4.
Adv Physiol Educ ; 46(3): 491-497, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-35796464

RESUMO

Professionalism and communication were formally introduced in India's Competency-Based Curriculum (CBC) as part of the five roles of an Indian medical graduate and 10 core competencies in the Bachelor of Science Nursing program. It may be challenging to teach the complexity of clinical medical ethics to undergraduate students at a young age in the absence of direct patient interaction. Trigger films (TFs) are brief (3-10 min) clips that have been used in the West to provoke debate, promote reflection, and assist trainees in dealing with ethical dilemmas. The aim of this study was to determine whether TFs can be used to teach professionalism and ethics to undergraduate medical and nursing students as an innovative and interesting tool and to see whether this results in any changes in knowledge. A 2-h module supported by an introductory PowerPoint presentation and using four TFs on the four pillars of ethics (beneficence, nonmaleficence, autonomy, and justice) was developed and piloted in the foundation course for the new cohort of medical and nursing students. Quantitative, open-ended feedback was taken from learners after module delivery, and knowledge was assessed with a retrospective pre-post questionnaire. The majority of students found TFs an innovative and interesting tool to teach medical ethics. There was a gain in knowledge of autonomy (52%), beneficence (48%), nonmaleficence (46%), and justice (38%). TFs can be effective tools to impart core competencies in ethics and professionalism to both nursing and medical students in the new CBC.NEW & NOTEWORTHY Teaching ethics is an important part of the medical curriculum, and since first-year students are not in direct contact with patients it is necessary to think of innovative methods that can be used to teach. We have done the pilot testing for the same, using trigger films among undergraduate medical and nursing students.


Assuntos
Educação de Graduação em Medicina , Estudantes de Medicina , Estudantes de Enfermagem , Currículo , Educação de Graduação em Medicina/métodos , Ética Médica , Humanos , Profissionalismo , Estudos Retrospectivos
5.
Inorg Chem ; 60(8): 6047-6056, 2021 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-33784818

RESUMO

A novel KGaS2 phosphor host that emits a cyan light was discovered to fill the cyan gap in the visible spectrum of phosphor-converted white light-emitting diodes (pc-wLEDs). KGaS2, belonging to the chalcogenometallates of the type ABQ2, was synthesized via a solid-state route with compositions optimized to achieve a phosphor host that would achieve the best photoluminescence (PL) properties. The activation with Eu2+ gave rise to PL in the cyan region of the spectrum with a PL maximum at ∼498 nm, as measured under the near-UV (420 nm) and blue (450 nm) excitations. The PL properties at the near-UV excitation are found to be much better, as compared to those obtained at the blue excitation. The Rietveld analysis, using high resolution synchrotron X-ray diffraction calibrated at a wavelength of 1.522 Å and selected area electron diffraction (SAED) pattern analysis of the composition optimized with the highest PL intensity, revealed a centrosymmetric monoclinic structure in the C2/c space group. The stoichiometry of the optimized composition, as estimated using Rietveld refinement, was revealed as KGa0.921S1.882:Eu2+. The decay curve measurement, using time-resolved spectroscopy, yielded a 10% decay time of 0.41 µs, which is much smaller compared with the decay time of the commercially available ß-SIALON phosphor that has a 10% decay time of 1.71 µs. The white pc-LED, fabricated with a cyan phosphor, had a higher value on the color rendering index and a lower value for color correlated temperatures, as compared with the version fabricated without a cyan phosphor, which makes this novel phosphor suitable for applications as a pc-wLED.

7.
Genomics ; 111(3): 297-309, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-29522800

RESUMO

Nematodes are responsible for causing severe diseases in plants, humans and other animals. Infection is associated with the release of Excretory/Secretory (ES) proteins into host cytoplasm and interference with the host immune system which make them attractive targets for therapeutic use. The identification of ES proteins through bioinformatics approaches is cost- and time-effective and could be used for screening of potential targets for parasitic diseases for further experimental studies. Here, we identified and functionally annotated 93,949 ES proteins, in the genome of 73 nematodes using integration of various bioinformatics tools. 30.6% of ES proteins were found to be supported at RNA level. The predicted ES proteins, annotated by Gene Ontology terms, domains, metabolic pathways, proteases and enzyme class analysis were enriched in molecular functions of proteases, protease inhibitors, c-type lectin and hydrolases which are strongly associated with typical functions of ES proteins. We identified a total of 452 ES proteins from human and plant parasitic nematodes, homologues to DrugBank-approved targets and C. elegans RNA interference phenotype genes which could represent potential targets for parasite control and provide valuable resource for further experimental studies to understand host-pathogen interactions.


Assuntos
Antinematódeos/farmacologia , Proteínas de Helminto/genética , Interações Hospedeiro-Patógeno , Nematoides/genética , Via Secretória , Animais , Genoma Helmíntico , Proteínas de Helminto/química , Proteínas de Helminto/metabolismo , Humanos , Nematoides/efeitos dos fármacos , Nematoides/patogenicidade , Plantas/parasitologia
8.
Med Humanit ; 46(4): 411-416, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31611284

RESUMO

Theatre of the Oppressed (TO) is a powerful participatory tool for communities to examine their struggles against oppression. The healthcare community has problems inherent to complex, unequal power equations, and TO may be a useful means to understand and respond to their struggle. A 3-day workshop on TO was facilitated by the authors in the Himalayan Institute of Medical Sciences (HIMS) in Dehradun, India, in August 2017. The workshop culminated in the 'Forum Theatre', which included five short plays, each depicting a struggle due to real-life oppression faced by one or the other participant. The audience (about 200 invited members of the HIMS community) chose one play depending on the struggle with which they identified most. That play was 'forumed': spectators were invited to replace the struggling person and demonstrate how they would handle the oppression. Over the next week, participants reflected on the workshop through a structured online questionnaire. The feedback (n=16/27 participants; response rate 59.3%) was subjected to descriptive statistics and to qualitative analysis. The highest average Likert score (out of a maximum of 5) was given to the following items: TO engages senses and emotions (4.6±0.50), can help inculcate ethical behaviour (4.4±0.81), identifies conflict (4.4±0.51), and resolves issues of attitude, behaviour, communication, diversity and empathy (4.4±0.73). The Forum Theatre was reported to be a means to "express emotions and opinions and to simultaneously gather the same from others"; "make people push their own limits"; "bring out social problems in public"; "examine the root causes behind lived experience"; "provide context for understanding and for exploring alternatives"; and "convert thoughts to action." In conclusion, TO is an engaging activity that identifies conflict; participants' initial reactions suggest that it may initiate change in the ABCDE attributes (attitude, behaviour, communication, diversity, ethics and empathy) of medical professionals.


Assuntos
Educação de Graduação em Medicina , Aprendizagem , Comunicação , Empatia , Humanos , Índia
9.
Small ; 14(49): e1803495, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30353995

RESUMO

KCrS2 is presented as a stable and high-rate layered material that can be used as a cathode in potassium-ion batteries. As far as it is known, KCrS2 is the only layered material with stoichiometric amounts of K+ , which enables coupling with a graphite anode for full-cell construction. Cr(III)/Cr(IV) redox in KCrS2 is also unique, because LiCrS2 and NaCrS2 are known to experience S2- /S2 2- redox. O3-KCrS2 is first charged to P3-K0.39 CrS2 and subsequently discharged to O'3-K0.8 CrS2 , delivering an initial discharge capacity of 71 mAh g-1 . The following charge/discharge (C/D) shows excellent reversibility between O'3-K0.8 CrS2 and P3-K0.39 CrS2 , retaining ≈90% of the initial capacity during 1000 continuous cycles. The rate performance is also noteworthy. A C/D rate increase of 100-fold (0.05 to 5 C) reduces the reversible capacity only by 39% (71 to 43 mAh g-1 ). The excellent cyclic stability and high rate performance are ascribed to the soft sulfide framework, which can effectively buffer the stress caused by K+ deinsertion/insertion. During the transformation between P3-K0.39 CrS2 and O'3-K0.8 CrS2 , the material resides mostly in the P3 phase, which minimizes the abrupt dimension change and allows facile K+ diffusion through spacious prismatic sites. Structural analysis and density functional theory calculations firmly support this reasoning.

10.
Phys Chem Chem Phys ; 20(41): 26405-26413, 2018 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-30306168

RESUMO

Here, we propose a new and logical approach to systematically treat the configurational diversity in density functional theory (DFT) calculations. To tackle this issue, we select Li0.5CoO2 as a representative example because it is one of the most extensively studied cathodes in Li-ion batteries (LIBs), and it has a huge number of disordered configurations. To delineate the configurations that will match well with the experimentally measured macro-functions of redox potential, band gap energy, and magnetic moment, we adopt a multi-objective, non-dominated sorting, genetic algorithm (NSGA-III) that enables the simultaneous optimization of these three objective functions. The decision variables include configuration of the Li/vacancy, initial input for the magnetic moment distribution reflecting Co3+/Co4+ distribution, and initial input for the lattice parameter and Hubbard U. We use NSGA-III to separate the configurations that exhibit awkward objective function values, which allows us to pinpoint a set of plausible configurations that match the experimentally estimated values of the objective functions. The results reveal a plausible configuration that is a mixture of various ordered/disordered configurations rather than a simple ordered structure.

11.
Adv Physiol Educ ; 42(1): 15-20, 2018 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-29341815

RESUMO

In the country presently, preclinical medical students are not routinely exposed to real patients. Thus, when they start clinical postings, they are found to have poor clinical reasoning skills. Simulated virtual patients (SVPs) can improve clinical skills without endangering real patients. This pilot study describes the development of two SVPs in endocrine physiology and their validation in terms of acquisition of clinical knowledge and student engagement. Two SVPs, Nandini Sharma (unintentional weight gain) and Sunil Yadav (polyuria), were created and published on the i-Human Patients platform through an iterative, interdisciplinary, and transdisciplinary collaborative process using the conceptual framework of Kim et al. (Kim S, Phillips WR, Pinsky L, Brock D, Phillips K, Keary J. Med Educ 40: 867-876, 2006). After internal and external peer validation, the SVPs were piloted on 40 students (20 students per virtual patient) over 2 wk. A cognitive pretest was conducted before exposure, and a posttest soon after. Faculty and student feedback were collected. Faculty found SVPs authentic, helpful as teaching-learning tools, and useful for giving feedback and for assessment. Students found SVPs more engaging than paper cases and helpful in developing clinical reasoning and in imparting clinical exposure. Pretest and posttest scores indicated knowledge gain ( P < 0.01). Although challenging to create, SVPs created on the i-Human Patients platform improved learning in endocrine physiology and were well accepted by students and faculty as a means to provide early clinical exposure. More SVPs can be developed through collaboration between stakeholder departments and integrated into the curriculum for greater benefit.


Assuntos
Competência Clínica/normas , Simulação por Computador/normas , Currículo/normas , Fisiologia/educação , Estudantes de Medicina , Interface Usuário-Computador , Endocrinologia/educação , Humanos , Projetos Piloto , Reprodutibilidade dos Testes
12.
Inorg Chem ; 56(16): 9814-9824, 2017 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-28776994

RESUMO

A metaheuristics-based design would be of great help in relieving the enormous experimental burdens faced during the combinatorial screening of a huge, multidimensional search space, while providing the same effect as total enumeration. In order to tackle the high-throughput powder processing complications and to secure practical phosphors, metaheuristics, an elitism-reinforced nondominated sorting genetic algorithm (NSGA-II), was employed in this study. The NSGA-II iteration targeted two objective functions. The first was to search for a higher emission efficacy. The second was to search for narrow-band green color emissions. The NSGA-II iteration finally converged on BaLi2Al2Si2N6:Eu2+ phosphors in the Eu2+-doped Ca-Sr-Ba-Li-Mg-Al-Si-Ge-N compositional search space. The BaLi2Al2Si2N6:Eu2+ phosphor, which was synthesized with no human intervention via the assistance of NSGA-II, was a clear single phase and gave an acceptable luminescence. The BaLi2Al2Si2N6:Eu2+ phosphor as well as all other phosphors that appeared during the NSGA-II iterations were examined in detail by employing powder X-ray diffraction-based Rietveld refinement, X-ray absorption near edge structure, density functional theory calculation, and time-resolved photoluminescence. The thermodynamic stability and the band structure plausibility were confirmed, and more importantly a novel approach to the energy transfer analysis was also introduced for BaLi2Al2Si2N6:Eu2+ phosphors.

13.
Phys Chem Chem Phys ; 19(25): 16702-16712, 2017 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-28621354

RESUMO

A novel oxynitride compound, Pr4-xCaxSi12O3+xN18-x, synthesized using a solid-state route has been characterized as a monoclinic structure in the C2 space group using Rietveld refinement on synchrotron powder X-ray diffraction data. The crystal structure of this compound was disordered due to the random distribution of Ca/Pr and N/O ions at various Wyckoff sites. A pragmatic approach for an ab initio calculation based on density function theory (DFT) for this disordered compound has been implemented to calculate an acceptable value of the band gap and formation energy. In general, for the DFT calculation of a disordered compound, a sufficiently large super cell and infinite variety of ensemble configurations is adopted to simulate the random distribution of ions; however, such an approach is time consuming and cost ineffective. Even a single unit cell model gave rise to 43 008 independent configurations as an input model for the DFT calculations. Since it was nearly impossible to calculate the formation energy and the band gap energy for all 43 008 configurations, an elitist non-dominated sorting genetic algorithm (NSGA-II) was employed to find the plausible configurations. In the NSGA-II, all 43 008 configurations were mathematically treated as genomes and the calculated band gap and the formation energy as the objective (fitness) function. Generalized gradient approximation (GGA) was first employed in the preliminary screening using NSGA-II, and thereafter a hybrid functional calculation (HSE06) was executed only for the most plausible GGA-relaxed configurations with lower formation and higher band gap energies. The final band gap energy (3.62 eV) obtained after averaging over the selected configurations, resembles closely the experimental band gap value (4.11 eV).

15.
Inorg Chem ; 55(20): 10310-10319, 2016 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-27676461

RESUMO

A solid-state combinatorial chemistry approach, which used the A-Ge-O (A = Li, K, Rb) system doped with a small amount of Mn4+ as an activator, was adopted in a search for novel red-emitting phosphors. The A site may have been composed of either a single alkali metal ion or of a combination of them. This approach led to the discovery of a novel phosphor in the above system with the chemical formula Li3RbGe8O18:Mn4+. The crystal structure of this novel phosphor was solved via direct methods, and subsequent Rietveld refinement revealed a trigonal structure in the P3̅1m space group. The discovered phosphor is believed to be novel in the sense that neither the crystal structure nor the chemical formula matches any of the prototype structures available in the crystallographic information database (ICDD or ICSD). The measured photoluminescence intensity that peaked at a wavelength of 667 nm was found to be much higher than the best intensity obtained among all the existing A2Ge4O9 (A = Li, K, Rb) compounds in the alkali-germanate system. An ab initio calculation based on density function theory (DFT) was conducted to verify the crystal structure model and compare the calculated value of the optical band gap with the experimental results. The optical band gap obtained from diffuse reflectance measurement (5.26 eV) and DFT calculation (4.64 eV) results were in very good agreement. The emission wavelength of this phosphor that exists in the deep red region of the electromagnetic spectrum may be very useful for increasing the color gamut of LED-based display devices such as ultrahigh-definition television (UHDTV) as per the ITU-R BT.2020-2 recommendations and also for down-converter phosphors that are used in solar-cell applications.

16.
Inorg Chem ; 54(4): 1829-40, 2015 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-25594669

RESUMO

The discovery of novel phosphors for use in light emitting diodes (LED) has gained in significance because LED-based solid-state lighting applications now attract a great deal of attention for energy savings and environmental concerns. Recent research trends have centered on the discovery of novel phosphors, not on slight variations of well-known phosphors. In a real sense, novelty goes beyond simple variations or improvements in existing phosphors. A brilliant strategy for the discovery of novel phosphors is to introduce an appropriate activator to existing inorganic compounds. These compounds have structures that are well-defined in crystallographic structure databases, but they have never been considered as a phosphor host. Another strategy is to discover new host compounds with structures that cannot be found in existing databases. We have simultaneously pursued both strategies by employing metaheuristics-assisted combinatorial material search techniques. In the present investigation, we screened a search space consisting of Ln-Al-Si-O-N (Ln = Y, La, Gd, Lu), and thereby we discovered a blue-light-emitting novel phosphor, Gd3Al(3+x)Si(3-x)O(12+x)N(2-x):Ce(3+), with a monoclinic system in the C2 space group--a potential candidate for UV-LED applications.

17.
J Am Chem Soc ; 136(6): 2363-73, 2014 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-24437942

RESUMO

Most of the novel phosphors that appear in the literature are either a variant of well-known materials or a hybrid material consisting of well-known materials. This situation has actually led to intellectual property (IP) complications in industry and several lawsuits have been the result. Therefore, the definition of a novel phosphor for use in light-emitting diodes should be clarified. A recent trend in phosphor-related IP applications has been to focus on the novel crystallographic structure, so that a slight composition variance and/or the hybrid of a well-known material would not qualify from either a scientific or an industrial point of view. In our previous studies, we employed a systematic materials discovery strategy combining heuristics optimization and a high-throughput process to secure the discovery of genuinely novel and brilliant phosphors that would be immediately ready for use in light emitting diodes. Despite such an achievement, this strategy requires further refinement to prove its versatility under any circumstance. To accomplish such demands, we improved our discovery strategy by incorporating an elitism-involved nondominated sorting genetic algorithm (NSGA-II) that would guarantee the discovery of truly novel phosphors in the present investigation. Using the improved discovery strategy, we discovered an Eu(2+)-doped AB5X8 (A = Sr or Ba, B = Si and Al, X = O and N) phosphor in an orthorhombic structure (A21am) with lattice parameters a = 9.48461(3) Å, b = 13.47194(6) Å, c = 5.77323(2) Å, α = ß = γ = 90°, which cannot be found in any of the existing inorganic compound databases.

18.
PLOS Glob Public Health ; 4(2): e0002933, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38422163

RESUMO

Despite having a higher burden of health problems, transgender persons face challenges in accessing healthcare in India. Most studies on healthcare access of transgender persons in India focus only on HIV related care, mental healthcare, gender affirmative services or on the ethno-cultural communities or transgender women. This study fills this gap by focusing on diverse gender identities within the transgender community with a specific focus on experiences in accessing general or routine healthcare services. A qualitative descriptive approach was used in this study. 23 in-depth interviews and 6 focus group discussions were conducted virtually and in-person with a total of 63 transgender persons in different regions of India between May and September 2021. The study used a community-based participatory research approach and was informed by the intersectionality approach. Thematic analysis was conducted to analyze the data. Four key themes emerged: (i) intersectional challenges in accessing healthcare start outside of the health system, continue through cisgender-binary-normative health systems that exclude transgender persons; and at the interface with individuals such as health professionals, support staff and bystanders; (ii) the experiences negatively impact transgender persons at an individual level; (iii) in response, transgender persons navigate these challenges across each of the levels: individual, health system level and from outside of the health system. This is a first of its kind qualitative participatory study focusing on routine healthcare services of transgender persons in India. The findings indicate the need to move conversations on trans-inclusion in healthcare from HIV and gender affirmative services to routine comprehensive healthcare services considering the higher burden of health problems in the community and the impact of poor access on their lives and well-being.

19.
J Commun Healthc ; : 1-10, 2024 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-38597810

RESUMO

BACKGROUND: Historical marginalisation and ongoing trust deficits in health and government systems shape present-day vaccine perceptions among marginalised communities. This paper sought to understand the role of trust in decision-making about COVID-19 vaccine uptake in the transgender and disability communities in India. METHODS: Using a participatory approach we interviewed 24 community representatives, identifying themselves as transgender individuals or as persons with disability, and 21 key informants such as vaccine programme managers, vaccine providers, and community advocates. We undertook an inductive thematic analysis of the data using a socio-ecological model. RESULTS: Fear of side effects in relation to specific needs of the two communities and mistrust of systems involved in vaccination shaped four different pathways for vaccine decision-making. Mistrust of systems was influenced by past negative experiences with the health system, creating contexts in which information and misinformation are shared and interpreted. Participants negotiated their doubts about safety and mistrust of systems by interacting with different sources of influence showing patterns of decision-making that are dynamic, context-dependent, and intersectional. CONCLUSION: These findings will help in determining the content, strategies and approaches to equitable vaccine communication for these two communities. The two communities ought to be included in vaccine trials. Vaccine information must respond to the specific needs of these two communities which could be enabled by collaboration and engagement with community members and influencers. Finally, long-term investment towards the needs of marginalised communities is vital to dismantle cycles of marginalisation and distrust and in turn improve vaccine acceptance and uptake.

20.
PLoS One ; 19(4): e0299785, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38598442

RESUMO

Intense cultivation with narrow row spacing in wheat, a common practice in the Indo-Gangetic plains of South Asia, renders the crop more susceptible to lodging during physiological maturity. This susceptibility, compounded by the use of traditional crop cultivars, has led to a substantial decline in overall crop productivity. In response to these challenges, a two-year field study on the system of wheat intensification (SWI) was conducted. The study involved three different cultivation methods in horizontal plots and four wheat genotypes in vertical plots, organized in a strip plot design. Our results exhibited that adoption of SWI at 20 cm × 20 cm resulted in significantly higher intercellular CO2 concentration (5.9-6.3%), transpiration rate (13.2-15.8%), stomatal conductance (55-59%), net photosynthetic rate (126-160%), and photosynthetically active radiation (PAR) interception (1.6-25.2%) over the existing conventional method (plant geometry 22.5 cm × continuous plant to plant spacing) of wheat cultivation. The lodging resistance capacity of both the lower and upper 3rd nodes was significantly higher in the SWI compared to other cultivation methods. Among different genotypes, HD 2967 demonstrated the highest recorded value for lodging resistance capacity, followed by HD 2851, HD 3086, and HD 2894. In addition, adoption of the SWI at 20 cm × 20 cm enhanced crop grain yield by 36.9-41.6%, and biological yield by 27.5-29.8%. Significantly higher soil dehydrogenase activity (12.06 µg TPF g-1 soil hr-1), arylsulfatase activity (82.8 µg p-nitro phenol g-1 soil hr-1), alkaline phosphatase activity (3.11 n moles ethylene g-1 soil hr-1), total polysaccharides, soil microbial biomass carbon, and soil chlorophyll content were also noted under SWI over conventional method of the production. Further, increased root volumes, surface root density and higher NPK uptake were recorded under SWI at 20×20 cm in comparison to rest of the treatments. Among the tested wheat genotypes, HD-2967 and HD-3086 had demonstrated notable increases in grain and biological yields, as well as improvements in the photosynthetically active radiation (PAR) and chlorophyll content. Therefore, adoption of SWI at 20 cm ×20 cm (square planting) with cultivars HD 2967 might be the best strategy for enhancing crop productivity and resource-use efficiency under the similar wheat growing conditions of India and similar agro-ecotypes of the globe.


Assuntos
Solo , Triticum , Triticum/genética , Água/análise , Clorofila , Biomassa , Grão Comestível/química
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