RESUMO
The effect of sotalol, a beta-adrenergic blocking drug, on the frequency of angina pectoris attacks and on exercise tolerance was evaluated by a double-blind cross-over study in 30 selected patients suffering from stable angina pectoris. Sotalol significantly reduced the mean number of attacks of angina, the consumption of glyceryl trinitrate tablets and the pulse rate at rest and in response to exercise. Effort tolerance as judged by a suboptimal 2-step test was improved significantly, as was electrocardiographic response. A relatively moderate dose of sotalol, 320 mg per day (160 mg twice daily), was sufficient in 80% of the patients. Side-effects were negligible.
Assuntos
Angina Pectoris/tratamento farmacológico , Sotalol/uso terapêutico , Adulto , Idoso , Angina Pectoris/fisiopatologia , Pressão Sanguínea/efeitos dos fármacos , Ensaios Clínicos como Assunto , Eletrocardiografia , Teste de Esforço , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Nitroglicerina/uso terapêutico , Sotalol/efeitos adversos , Sotalol/farmacologiaRESUMO
In 20 patients suffering from parkinsonism, L-dopa produced maximal benefit after 3 years. A decline in the response then occurred, but considerable benefit was still derived after 5 years by patients who had improved initially. The effect of the drug on the symptomatology is reviewed. Whether the mortality rate in parkinsonism is improved by L-dopa is undecided, but recent publications and the present study indicate that the life expectancy is prolonged.
Assuntos
Levodopa/uso terapêutico , Doença de Parkinson/tratamento farmacológico , Adulto , Idoso , Benserazida/uso terapêutico , Quimioterapia Combinada , Feminino , Seguimentos , Humanos , Expectativa de Vida , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/mortalidade , Fatores de TempoRESUMO
A 45-year-old White man presented with multiple aneurysm formation and severe constitutional symptoms, the control of which entailed long-term corticosteroid therapy. Early in the patient's clinical course, two aneurysms were resected, and at subsequent postmortem examination the vascular lesions were found to be inactive and fibrosed, which suggested that the corticosteroids had been effective in controlling the inflammatory reaction. Of special interest was the development of diffuse lymphoma of the large cell type (histiocytic lymphoma) late in the course of the disease. This report emphasises the association between immunosuppressive therapy and subsequent neoplasia, and stresses the need for caution in the administration of these agents to patients whose condition is benign.