1.
Org Lett
; 26(3): 625-630, 2024 Jan 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38206574
RESUMO
We report a general copper/iodine co-catalyzed oxygenative transannulation strategy using readily available tryptamines. Molecular oxygen and water are used as oxygen sources and provide direct access to the donaxaridine scaffold and its derivatives. This methodology is applied to the efficient synthesis of the natural products donaxaridine, chimonamidine, donaxanine, donaxarine, and aline in just one or two steps. The tryptamines, albeit with oxy-sensitive dialkyl N-H groups, are selectively oxidized through a single-electron transfer dioxygenation process.