RESUMO
This study was performed to investigate the antioxidant mechanisms of polymorphonuclear leucocytes (PMN) in active stage of Behçet's Disease. PMN activities of myeloperoxidase (p < 0.02), superoxide dismutase (p < 0.001), catalase (p < 0.005), and glutathione peroxidase (p < 0.005) were significantly lower in the patients: the NADPH oxidase activity was significantly higher (p < 0.001) than those in controls. The plasma levels of ceruloplasmin (Cp), fibrinogen, and copper (Cu) were also significantly higher in the patients group (p < 0.001). Significant and positive correlations were found between the glutathione peroxidase and catalase activities (p < 0.001) and also between the plasma Cp and Cu levels (p < 0.001) in the patients group. However, no correlation was observed among the other enzyme activities. In the control group, a significantly positive correlation was present only between the plasma ceruloplasmin and Cu levels (p < 0.001). It was concluded that (impaired PMN functions) decreased enzyme activities in the antioxidant system and increased levels of oxygen free radicals may play a role in tissue damage in Behçet's disease.
Assuntos
Síndrome de Behçet/sangue , Ceruloplasmina/metabolismo , Cobre/sangue , Fibrinogênio/metabolismo , Neutrófilos/enzimologia , Oxirredutases/metabolismo , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Transtornos de Ansiedade/enzimologia , Transtorno Depressivo/enzimologia , Isoenzimas/sangue , Monoaminoxidase/sangue , Adolescente , Adulto , Fatores Etários , Transtornos de Ansiedade/diagnóstico , Transtornos de Ansiedade/psicologia , Transtorno Depressivo/diagnóstico , Transtorno Depressivo/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Determinação da PersonalidadeAssuntos
Transtorno Bipolar/tratamento farmacológico , Contagem de Eritrócitos/efeitos dos fármacos , Hidrocortisona/sangue , Contagem de Leucócitos/efeitos dos fármacos , Lítio/efeitos adversos , Adulto , Transtorno Bipolar/sangue , Transtorno Bipolar/psicologia , Feminino , Granulócitos/efeitos dos fármacos , Humanos , Leucocitose/sangue , Leucocitose/induzido quimicamente , Lítio/farmacocinética , Lítio/uso terapêutico , MasculinoRESUMO
The levels of superoxide dismutase (SOD) and myeloperoxidase (MPO) in polymorphonuclear leukocytes (PMN), and serum ceruloplasmin activity and copper content, were measured in 60 patients with psoriasis and 33 healthy controls. There were no significant differences in the activity of MPO between the patients and the controls. However, SOD activity in PMN was significantly lower in the patients than in the controls. Serum ceruloplasmin activity and copper levels were significantly higher in the psoriatics than in the controls.