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1.
BMC Fam Pract ; 21(1): 155, 2020 07 30.
Artigo em Inglês | MEDLINE | ID: mdl-32731852

RESUMO

BACKGROUND: Domestic violence is common in the community. Many of its victims present to primary care physicians (PCPs) but are not being recognized and managed. The barriers, with specific reference to a Chinese cultural context, were investigated earlier. This paper explored the factors which facilitated the process of recognizing and managing suspected cases of domestic violence by PCPs in Hong Kong. METHODS: Four focus group interviews were conducted to explore in-depth the experiences of PCPs in recognition, management and referral of domestic violence cases from which facilitators were identified. The relevant themes were then investigated in a questionnaire survey with 504 PCPs working in public and private sectors. RESULTS: The focus group participants emphasized mood symptoms as useful indicators for probable abuse and continuity of care was important to unmask issues of domestic violence. The top facilitators perceived by the respondents of the survey included: a trusting doctor-patient relationship (99.8%), good communication skills (99.0%), patients' unexplained bruises (96.3%), medical history (94.6%), and mood symptoms (94.4%). Further, the survey found that PCPs with longer years of practice, a medical degree obtained from Western countries, and postgraduate training in family counselling or psychological medicine perceived more facilitators in managing domestic violence. CONCLUSIONS: Without a local screening policy and training protocol to manage domestic violence, PCPs regarded their skills in mental healthcare and good relationships with patients as the key facilitators. While training in mental health care helps PCPs manage domestic violence, a specific protocol emphasizing medical-social collaboration is anticipated to facilitate them to take a more proactive and effective stance from screening to management.


Assuntos
Violência Doméstica , Médicos de Atenção Primária , China , Hong Kong , Humanos , Relações Médico-Paciente
2.
J Med Internet Res ; 22(3): e16769, 2020 03 27.
Artigo em Inglês | MEDLINE | ID: mdl-32217498

RESUMO

BACKGROUND: Technological surrogate nursing (TSN) derives from the idea that nurse-caregiver substitutes can be created by technology to support chronic disease self-care. OBJECTIVE: This paper begins by arguing that TSN is a useful and viable approach to chronic disease self-care. The analysis then focuses on the empirical research question of testing and demonstrating the effectiveness and safety of prototype TSN supplied to patients with the typical complex chronic disease of coexisting type 2 diabetes and hypertension. At the policy level, it is shown that the data allow for a calibration of TSN technology augmentation, which can be readily applied to health care management. METHODS: A 24-week, parallel-group, randomized controlled trial (RCT) was designed and implemented among diabetic and hypertensive outpatients in two Hong Kong public hospitals. Participants were randomly assigned to an intervention group, supplied with a tablet-based TSN app prototype, or to a conventional self-managing control group. Primary indices-hemoglobin A1c, systolic blood pressure, and diastolic blood pressure-and secondary indices were measured at baseline and at 8, 12, 16, and 24 weeks after initiation, after which the data were applied to test TSN effectiveness and safety. RESULTS: A total of 299 participating patients were randomized to the intervention group (n=151) or the control group (n=148). Statistically significant outcomes that directly indicated TSN effectiveness in terms of hemoglobin 1c were found in both groups but not with regard to systolic and diastolic blood pressure. These findings also offered indirect empirical support for TSN safety. Statistically significant comparative changes in these primary indices were not observed between the groups but were suggestive of an operational calibration of TSN technology augmentation. Statistically significant changes in secondary indices were obtained in one or both groups, but not between the groups. CONCLUSIONS: The RCT's strong behavioral basis, as well as the importance of safety and effectiveness when complex chronic illness is proximately self-managed by layperson patients, prompted the formulation of the empirical joint hypothesis that TSN would improve patient self-care while satisfying the condition of patient self-safety. Statistical and decision analysis applied to the experimental outcomes offered support for this hypothesis. Policy relevance of the research is demonstrated by the derivation of a data-grounded operational calibration of TSN technology augmentation with ready application to health care management. TRIAL REGISTRATION: ClinicalTrials.gov NCT02799953; https://clinicaltrials.gov/ct2/show/NCT02799953.


Assuntos
Diabetes Mellitus Tipo 2/enfermagem , Diabetes Mellitus Tipo 2/terapia , Hipertensão/enfermagem , Hipertensão/terapia , Cuidados de Enfermagem/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Autocuidado
3.
J Nurs Scholarsh ; 52(3): 242-249, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32154988

RESUMO

PURPOSE: Intimate partner violence against women is a priority global health issue. It has had serious negative consequences on women's health and has led to huge burdens on the community. Numerous interventions have been demonstrated to have positive effects, and the majority of them have been developed using a top-down approach. However, the specific needs of abused Chinese women have not been fully addressed; incorporating women's input seems to be an essential element for the success of any intervention. This article describes the experiences and success in using a community-based participatory approach (CBPA) to develop a culturally appropriate intervention for abused Chinese women in order to address their multifaceted needs. DESIGN: A CBPA was adopted in this study to develop a culturally appropriate intervention in order to address the multifaceted needs of abused Chinese women. METHODS: A core group of six participants (three abused Chinese women, one researcher, and two social workers who provided community services for abused Chinese women) was formed in a local community center in Hong Kong. The three Chinese women were recruited from the local community center, and according to the Abuse Assessment Screen they had been in an intimate relationship in the preceding 12 months and had been abused by an intimate partner. FINDINGS: Three core group meetings were conducted over 6 weeks for intervention development. An integrated multicomponent intervention was developed, comprising a four-part, women-centered program called "Women-centred, we are with you." The program was implemented and completed over 4 months (October 2015 to January 2016). Eighteen abused Chinese women participated in the intervention. CONCLUSIONS: A CBPA provides actual empowerment spirit for abused Chinese women. This approach was well accepted by the women and enabled them to develop more culturally appropriate interventions in fulfilling their specify needs. CLINICAL RELEVANCE: Researchers can consider using a CBPA to develop and tailor a culturally appropriate intervention for groups such as abused Chinese women in order to improve their health and eliminate disparities by addressing their specific and multifaceted needs.


Assuntos
Pesquisa Participativa Baseada na Comunidade , Necessidades e Demandas de Serviços de Saúde , Violência por Parceiro Íntimo , Adulto , Competência Cultural , Feminino , Hong Kong , Humanos , Avaliação de Programas e Projetos de Saúde , Saúde da Mulher
4.
Pediatr Res ; 85(4): 449-455, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30679794

RESUMO

BACKGROUND: This study aims to study prospectively specific sleep patterns and risk of ADHD after adjusting for potential confounders such as obstructive sleep apnoea (OSA) and methylphenidate use. METHODS: A population-representative sample of 514 Chinese preschool children was recruited when in kindergarten (K3). Parents reported on their socioeconomic status and children's sleep duration. The cohort was reassessed 3 years later when the children were in Grade 3 (P3). Parents reported on children's sleep patterns and ADHD symptoms. Information on OSA diagnosis and methylphenidate use was retrieved from health records. RESULTS: Among the 514 parent-child dyads (mean [SD] age, 5.52 [0.33] years), 411 were reassessed (80.0% retention; 9.35 [0.33] years) at follow-up. There were no significant baseline differences between follow-up and drop-out groups. A gradient relationship was observed between probable ADHD in P3 and sleep duration in K3. The risk of probable ADHD was 15.5 per 100 for children with <8 h of sleep in K3, whereas it was 1.1 per 100 for children with 11-12 h of sleep in K3. The adjusted risk ratio was 14.19 (p = 0.02). CONCLUSIONS: Sleep deprivation in early childhood is associated with higher risk of ADHD in middle childhood.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/complicações , Privação do Sono , Criança , Pré-Escolar , China , Feminino , Humanos , Masculino , Estudos Prospectivos , Fatores Socioeconômicos
5.
J Med Syst ; 43(9): 293, 2019 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-31338682

RESUMO

eHealth has become popular worldwide, and it is transforming health care. However, studies examining  the use of eHealth applications in the Chinese population are scarce. The study reports on the characteristics of eHealth applications in Hong Kong information and communication technology (ICT) users, their attitudes towards eHealth, and their reasons for not using eHealth applications. A cross-sectional random-digit dialing survey targeting adults using ICT was conducted in Hong Kong to elicit information on respondents' use of and attitudes towards eHealth. A total of 495 ICT users completed the survey, of whom 353 (71.3%) were eHealth users. A smartphone was the most frequent way of performing eHealth activities (71.7%). The most prevalent eHealth activity was reading about health/illness (86.4%), with 93.5% indicating that eHealth applications improved their understanding of health care issues. People with less education were less likely to use eHealth applications. Non-eHealth users indicated that the main reasons for not using eHealth applications were lack of interest in health information (49.3%) and lack of confidence in the reliability of online information (45.1%). Quality monitoring of health information available on ICTs and tailoring the design and readability are recommended to meet the needs of those seeking health resources and to promote eHealth. Evidence from the study demonstrates the potential of eHealth to improve the dissemination of health information in Hong Kong, and it provides a basis for improving eHealth integration.


Assuntos
Atitude , Smartphone , Telemedicina/métodos , Adolescente , Adulto , Informação de Saúde ao Consumidor , Estudos Transversais , Feminino , Hong Kong , Humanos , Internet , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Fatores Socioeconômicos , Telemedicina/normas , Adulto Jovem
6.
Health Care Women Int ; 40(1): 102-117, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30676889

RESUMO

Current understandings of the effects trauma exposure on women's health are limited because prior research has largely focused on intimate partner and sexual violence in homogenous samples. In this descriptive study, the authors examined the relationships between lifetime trauma exposure and psychological well-being among women across the Pacific Rim. Psychological well-being differed significantly between the four locations and increased trauma exposures were related to poorer psychological well-being across and within locations. The authors report relevant findings on the relationship between trauma exposure and psychological well-being and provide evidence for future research to enhance knowledge on the effects of trauma in women's lives.


Assuntos
Trauma Psicológico/epidemiologia , Transtornos de Estresse Pós-Traumáticos/epidemiologia , Estresse Psicológico/etiologia , Saúde da Mulher/etnologia , Adolescente , Adulto , Idoso , Colômbia/epidemiologia , Feminino , Hong Kong/epidemiologia , Humanos , Saúde Mental , Pessoa de Meia-Idade , Trauma Psicológico/psicologia , Transtornos de Estresse Pós-Traumáticos/psicologia , Estresse Psicológico/psicologia , Estados Unidos/epidemiologia , Adulto Jovem
7.
Aging Ment Health ; 22(11): 1448-1455, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-28812377

RESUMO

OBJECTIVES: This study examined the potential influence of coping resources at individual (sense of mastery), family (spousal and family support, children's filial piety), and community levels (community cohesion) on the mental health (depression, anxiety) of U.S. Chinese older adults. METHODS: The data were derived from the Population Study of Chinese Elderly in Chicago (N= 3,159). Negative binomial regressions were performed to predict depression and anxiety, respectively, by entering the three sets of coping resources separately and jointly, controlling for socio-demographic and acculturation variables. RESULTS: Stronger sense of mastery and greater perception of children's filial piety were associated with better mental health outcomes. Spousal support was not associated with any mental health outomes, and family support was actually assciated with greater depression and anxiety. Stronger community cohesion was associated with fewer depressive symptoms but greater anxiety. CONCLUSION: Older immigrants' sense of control and perception that children adhere to traditional family norms are important mental health protective factors. Whereas depending on families for support may compromise their well-being, community cohesion could be a double-edged sword for their mental health. Future studies shall further disentangle the associations among sense of mastery, reliance on family and ethnic enclaves for support, and older immigrants' well-being.


Assuntos
Adaptação Psicológica , Envelhecimento/etnologia , Ansiedade/etnologia , Asiático/psicologia , Depressão/etnologia , Família/etnologia , Autoeficácia , Meio Social , Apoio Social , Idoso , Idoso de 80 Anos ou mais , Chicago/etnologia , China/etnologia , Estudos Transversais , Emigrantes e Imigrantes/psicologia , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Relações Pais-Filho/etnologia , Cônjuges/etnologia
8.
J Med Syst ; 42(10): 191, 2018 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-30187139

RESUMO

A Qigong App was designed to promote a more flexible mode of delivering qigong training than face-to-face, with which individuals can access to this mind-body aerobic exercise more readily. The objective of the study was to examine the usability and acceptance of the App. Target participants were Cantonese- or Putonghua-speaking adults and owned a smartphone. First we conducted a pilot trial with 14 participants to examine the navigation feature of the App, followed by a main test. In the main test, another 100 participants reviewed the Qigong App and filled in a questionnaire on usability (System Usability Scale) and user acceptance (i.e., attitude, perceived ease of use, perceived usefulness, intention to use, and satisfaction), of which 89 completed the same questionnaire in a two-week interval. Qualitative feedback yielded from the pilot trial was summarized, and descriptive statistics, t-tests, and linear regressions were used in quantitative data analysis of the main test. The mean composite usability score in the main test was satisfactory (77.62 out of 100). Descriptive analyses showed that the majority of users found the Qigong App pleasant, user friendly, and useful for learning qigong. Participants indicated positive ratings for the items assessing usability and acceptance of the App. Regression results showed that certain characteristics predicted the ratings for some items, e.g., age as a predictor of scores of usability and perceived ease of use. The study provided researchers and practitioners with evidence of the usability and acceptance of an alternative qigong training mode that can enhance participants' access and motivation to practice qigong.


Assuntos
Aplicativos Móveis , Qigong , Smartphone , Interface Usuário-Computador , Adulto , Estudos Transversais , Hong Kong , Humanos
9.
Qual Life Res ; 26(12): 3297-3306, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-28741262

RESUMO

PURPOSE: To explore the association between maternal intimate partner abuse (IPA) and their children's health-related quality of life (HRQOL) and behavioural problem, and to establish a mediation model and investigate the mediating role of mothers' HRQOL on this association. METHODS: A cross-sectional study was conducted on 197 mothers of 227 children (112 boys and 115 girls) from low-income Chinese families. The mothers were asked to complete the 5-item abuse assessment screen questionnaire for the presence of IPA, the Chinese (Hong Kong) version of 12-item Short-Form Health Survey (SF-12) for their HRQOL and a structured socio-demographics questionnaire. One of the parents completed the Child Health Questionnaire-Parent Form-50 (CHQ-PF50) and the strengths and difficulties questionnaire (SDQ) to report on their children's HRQOL and behavioural problems, respectively. The mediating effect of the maternal HRQOL on the relationship between maternal IPA status and their children's behavioural problems and HRQOL was tested using Baron and Kenney's multistage regression approach and bootstrapping method. RESULTS: Thirty-five of the 197 mothers reported IPA (17.8%). Children whose mothers had experienced IPA had lower scores in the CHQ-PF50 mental health, parental impact-emotional, family activities and family cohesion subscales, and the psychosocial summary score compared to children of mothers who reported no IPA; they also had more emotional, conduct and hyperactivity/inattention problems and higher total difficulties scores measured by the SDQ. Maternal mental HRQOL was a mediator on the relationship between maternal IPA status and their children's behavioural problems and psychosocial HRQOL. CONCLUSION: IPA experienced by mothers had significant negative impacts on their children's HRQOL and behaviours, which was mediated by maternal mental HRQOL.


Assuntos
Comportamento Infantil/psicologia , Violência por Parceiro Íntimo/psicologia , Transtornos Mentais/psicologia , Mães/psicologia , Perfil de Impacto da Doença , Adulto , Criança , China , Estudos Transversais , Feminino , Humanos , Masculino , Pobreza , Inquéritos e Questionários
10.
J Nurs Scholarsh ; 49(3): 286-293, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28388838

RESUMO

PURPOSE: Healthcare professionals who provide services in the immediate or long-term aftermath of traumatic events need to understand the nature and frequency of traumatic events in the lives of women. However, research on trauma exposure in women has only recently begun to assess events other than intimate partner and sexual violence and has not supported direct statistical comparison of cross-national and cross-cultural data. The purpose of this descriptive, correlational study was to describe and compare trauma exposure prevalence and type in community-based samples of women in the United States, Colombia, and Hong Kong. DESIGN: Women were recruited through posted notices at community health sites, snowball sampling, and online advertisements (N = 576). The Life Stressor Checklist-Revised (total score range 0 to 30) was used to determine the type and prevalence of trauma exposure. Data were collected by native language members of the research team. METHODS: Descriptive statistics were used to summarize demographic characteristics and trauma exposure for the total sample and each community-based sample (location). Between-location differences were tested using Fisher's exact tests for categorical measures and general linear models with pairwise a posteriori least squares t-test for continuous measures. Responses to open-ended questions were translated and categorized. FINDINGS: Over 99% of women in the total sample reported at least one traumatic life event. The mean number of traumatic life events per participant was 7, ranging from 0 to 24. Although there was consistency in the most commonly reported trauma exposures across locations, the rates of specific events often differed. CONCLUSIONS: Historical, political, geographic, and cultural factors may explain differences in trauma exposure among women in the four locations studied. CLINICAL RELEVANCE: This study offers relevant knowledge for providers in diverse locations who provide services to women who have experienced traumatic events and provides evidence for the need for future research to further enhance knowledge of trauma exposure among women, and on the effects of trauma in women's lives.


Assuntos
Trauma Psicológico/epidemiologia , Adolescente , Adulto , Idoso , Colômbia/epidemiologia , Feminino , Hong Kong/epidemiologia , Humanos , Pessoa de Meia-Idade , Prevalência , Estados Unidos/epidemiologia , Adulto Jovem
11.
Depress Anxiety ; 33(12): 1123-1131, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27618799

RESUMO

BACKGROUND: Depression prevention among adolescents is crucial for reducing the global disease burden. Internet-based depression prevention approaches are found to be effective but they were mostly evaluated in a Western context. Grasping the Opportunity is a Chinese Internet intervention, which was translated and modified from CATCH-IT developed in the West. We aimed to evaluate the effectiveness of Grasp the Opportunity in reducing depressive symptoms in Chinese adolescents. METHODS: In this randomized controlled trial, Chinese adolescents aged 13 to 17 years with mild-to-moderate depressive symptoms were recruited from three secondary schools in Hong Kong. The participants (n = 257) were randomly assigned to receive either intervention or attention control. The primary outcome was the improvement in depressive symptoms according to the revised Center for Epidemiologic Studies Depression Scale (CESD-R) at the 12-month follow-up. Analyses were performed using intention to treat (ITT). RESULTS: The participants were randomly assigned to receive the intervention (n = 130) or attention control (n = 127). Follow-up data were obtained from 250 (97%) participants. Only 26 (10%) participants completed the intervention. Compared to the attention control, Grasp the Opportunity led to reductions in depressive symptoms at the 12-month follow-up with a medium effect size using ITT analysis (mean difference 2.6, 95% CI 0.59-5.55, effect size d = 0.36). CONCLUSIONS: Grasp the Opportunity is effective in reducing depressive symptoms in Chinese adolescents over a long follow-up period. Poor completion rate is the major challenge in the study.


Assuntos
Assistência à Saúde Culturalmente Competente/métodos , Transtorno Depressivo/prevenção & controle , Internet , Avaliação de Programas e Projetos de Saúde/métodos , Adolescente , Comportamento do Adolescente/psicologia , Transtorno Depressivo/psicologia , Feminino , Hong Kong , Humanos , Masculino
12.
BMC Complement Altern Med ; 16(1): 424, 2016 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-27793197

RESUMO

BACKGROUND: Caregiving can be stressful, potentially creating physical and psychological strain. Substantial evidence has shown that family caregivers suffer from significant health problems arising from the demands of caregiving. Although there are programs supporting caregivers, there is little evidence regarding their effectiveness. Acupressure is an ancient Chinese healing method designed to restore the flow of Qi (vital energy) by applying external pressure to acupoints. A randomized, wait-list controlled trial was developed to evaluate the effectiveness of a self-administered acupressure intervention on caregiver stress (primary objective) and stress-related symptoms of fatigue, insomnia, depression, and health-related quality of life (secondary objectives) in Chinese caregivers of older family members. METHODS: Two hundred Chinese participants, aged ≥ 21 years, who are the primary caregivers of an older family member and screen positive for caregiver stress and symptoms of fatigue/insomnia/depression will be recruited from a community setting in Hong Kong. Subjects will be randomized to receive either an immediate treatment condition (self-administered acupressure intervention) or a wait-list control condition. The self-administered acupressure intervention will include (i) an individual learning and practice session twice a week for 2 weeks, (ii) a home follow-up visit once a week for 2 weeks, and (iii) 15-min self-practice twice a day for 6 weeks. The wait-list control group will receive the same acupressure training after the intervention group has completed the intervention. We hypothesize that Chinese family caregivers in the intervention group will have lower levels of caregiver stress, fatigue, insomnia, depression, and higher health-related quality of life after completion of the intervention than participants in the wait-list control group. DISCUSSION: This study will provide evidence for the effectiveness of self-administered acupressure in reducing stress and improving symptoms of fatigue, insomnia, depression, and health-related quality of life in Chinese family caregivers. The findings will inform the design of interventions to relieve negative health effects of caregiving. Furthermore, the results can raise community awareness and serve as a basis for policymaking, planning, and allocation of resources regarding empowerment of family caregivers for self-care. TRIAL REGISTRATION: Current Controlled Trials NCT02526446 . Registered August 10, 2015.


Assuntos
Acupressão/métodos , Cuidadores , Autocuidado/métodos , Estresse Psicológico/terapia , Adulto , China , Depressão/terapia , Fadiga/terapia , Feminino , Humanos , Masculino , Adulto Jovem
13.
Nurs Health Sci ; 18(3): 393-9, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27103595

RESUMO

International concerns relating to healthcare professionals' failure to rescue deteriorating patients exist. Web-based training programs have been developed and evaluated in Western settings but further testing is required before application in non-Western countries, as traditional modalities of learning may differ between cultures. We trialed an Australian English language online simulation program for the management of deteriorating patients, Feedback Incorporating Review and Simulation Techniques to Act on Clinical Trends (FIRST(2) ACTWeb), to test cultural acceptability, transferability, and educational impact. The study was designed as a quasi-experimental evaluation of the FIRST(2) ACTWeb program with final year nursing students from a Bachelor of Nursing program at the University of Hong Kong. Participants completed pre-course and post-course tests, three interactive scenarios, and program evaluations. The program was positively evaluated, with significant improvements in knowledge, skills, self-rating of performance, confidence, and competence. Outcomes were comparable to earlier evaluations with Australian students, demonstrating that an interactive simulation-based program of patient deterioration management has cultural and language acceptability and transferability across communities with significant educational impact.


Assuntos
Aprendizagem , Avaliação em Enfermagem/métodos , Avaliação em Enfermagem/normas , Cuidados de Enfermagem/normas , Simulação de Paciente , Estudantes de Enfermagem/psicologia , Feminino , Hong Kong , Humanos , Masculino , Software/normas , Adulto Jovem
14.
Int J Cancer ; 136(6): 1361-70, 2015 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-25131797

RESUMO

Apart from regulating stem cell self-renewal, embryonic development and proliferation, Bmi-1 has been recently reported to be critical in the maintenance of genome integrity. In searching for novel mechanisms underlying the anticlastogenic function of Bmi-1, we observed, for the first time, that Bmi-1 positively regulates p21 expression. We extended the finding that Bmi-1 deficiency induced chromosome breaks in multiple cancer cell models. Interestingly, we further demonstrated that knockdown of cyclin E or ectopic overexpression of p21 rescued Bmi-1 deficiency-induced chromosome breaks. We therefore conclude that p21/cyclin E pathway is crucial in modulating the anticlastogenic function of Bmi-1. As it is well established that the overexpression of cyclin E potently induces genome instability and p21 suppresses the function of cyclin E, the novel and important implication from our findings is that Bmi-1 plays an important role in limiting genomic instability in cylin E-overexpressing cancer cells by positive regulation of p21.


Assuntos
Ciclina E/fisiologia , Inibidor de Quinase Dependente de Ciclina p21/fisiologia , Instabilidade Genômica , Complexo Repressor Polycomb 1/fisiologia , Transdução de Sinais/fisiologia , Linhagem Celular Tumoral , Aberrações Cromossômicas , Humanos
15.
Cytokine ; 72(1): 86-96, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25573802

RESUMO

One consequence of modern cancer therapy is chemotherapy related cognitive dysfunction or "chemobrain", the subjective experience of cognitive deficits at any point during or following chemotherapy. Chemobrain, a well-established clinical syndrome, has become an increasing concern because the number of long-term cancer survivors is growing dramatically. There is strong evidence that correlates changes in peripheral cytokines with the development of chemobrain in commonly used chemotherapeutic drugs for different types of cancer. However, the mechanisms by which these cytokines elicit change in the central nervous system are still unclear. In this review, we hypothesize that the administration of chemotherapy agents initiates a cascade of biological changes, with short-lived alterations in the cytokine milieu inducing persistent epigenetic alterations. These epigenetic changes lead to changes in gene expression, alterations in metabolic activity and neuronal transmission that are responsible for generating the subjective experience of cognition. This speculative but testable hypothesis should help to gain a comprehensive understanding of the mechanism underlying cognitive dysfunction in cancer patients. Such knowledge is critical to identify pharmaceutical targets with the potential to prevent and treat cancer-treatment related cognitive dysfunction and similar disorders.


Assuntos
Antineoplásicos/efeitos adversos , Encéfalo/efeitos dos fármacos , Encéfalo/fisiopatologia , Transtornos Cognitivos/induzido quimicamente , Citocinas/metabolismo , Epigênese Genética , Neoplasias/tratamento farmacológico , Antineoplásicos/uso terapêutico , Humanos , Qualidade de Vida
16.
BMC Public Health ; 15: 314, 2015 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-25886388

RESUMO

BACKGROUND: Distinctions have been made between the two main forms of intimate partner violence: intimate terrorism (IT) and situational couple violence (SCV), depending on whether the violence is part of a general pattern of control. Differential effects also exist between IT and SCV. However, the IT/SCV distinction and their differential effects have yet to be demonstrated in violent intimate relationships in China. We aimed to identify IT and SCV among Chinese women who reported partner violence in Hong Kong and to differentiate the effects of IT and SCV on their mental health outcomes. METHODS: A mixed-method design was used in a cross-sectional study to collect quantitative and qualitative data from women 18 years of age or older who had been victims of intimate partner violence in the past year. Six hundred and thirteen women were recruited from 18 districts in Hong Kong. Quantitative instruments were administered to assess intimate partner violence, control by an intimate partner, and mental health outcomes. Individual face-to-face interviews were conducted with 200 of the women to capture their experiences of intimate partner violence and the context in which it occurred. RESULTS: Of the 613 women, 215 (35.1%) were identified as victims of IT and 324 (52.9%) as victims of SCV. Compared to SCV victims, IT victims reported significantly more violence-related physical injury (p < 0.001), higher use of medical services (p < 0.001), and more symptoms of depression (p < 0.001) and posttraumatic stress disorder (p < 0.001). The interviews revealed two broadly different pictures with IT victims describing their relationship problems as serious and life-threatening, and physical violence was part of the controlling behaviors used by their partners. Such details were not reported by those in the SCV group. CONCLUSION: Our findings indicate that violence in intimate relationships in China is not a unitary phenomenon, and it has at least two forms, IT and SCV, which were shown to have differential effects on Chinese women. The findings regarding the IT/SCV distinction and their differential effects on mental health outcomes have implications for policy, research and practice. TRIAL REGISTRATION: Trial registration: ClinicalTrials.gov NCT01206192.


Assuntos
Mulheres Maltratadas/psicologia , Transtornos Mentais/psicologia , Parceiros Sexuais/psicologia , Maus-Tratos Conjugais/psicologia , Adulto , Agressão/psicologia , Estudos Transversais , Feminino , Hong Kong , Humanos , Entrevistas como Assunto , Pessoa de Meia-Idade , Adulto Jovem
17.
J Elder Abuse Negl ; 27(4-5): 428-37, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26383961

RESUMO

Intimate partner violence has long been recognized as a serious public health problem. However, relatively little is known about its occurrence in late life (age 60 or above). A better understanding of this complex phenomenon is needed, partly because of aging populations worldwide and partly because of the necessity to protect vulnerable older people from the harm a violent partner might cause. The current case study aims to illustrate the duality of experience and the dynamics of intimate partner violence of two older Chinese women. It is hoped that the women's accounts may stimulate dialogue on how policy, research, and practice can be directed to protecting vulnerable older adults and reducing intimate partner violence in late life.


Assuntos
Agressão , Abuso de Idosos , Violência por Parceiro Íntimo , Parceiros Sexuais , Maus-Tratos Conjugais , Idoso , Idoso de 80 Anos ou mais , China , Feminino , Humanos , Relações Interpessoais , Masculino , Pessoa de Meia-Idade
18.
Qual Life Res ; 23(9): 2489-94, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24894382

RESUMO

PURPOSE: The aim of this study was to report translation and transcultural adaptation of the 15-item Dispositional Resilience Scale in traditional Chinese (C-DRS-15) and evaluate its psychometric properties. METHODS: The DRS is a self-report instrument that measures psychological hardiness. We followed an international standard of cross-cultural translation and validation of patient-reported outcome measures to create the Chinese version. Then, the translated C-DRS-15 was validated on 542 Chinese women from a population-based sample in Hong Kong. RESULTS: The internal consistency and criterion-related validity were investigated. Exploratory and confirmatory factor analysis revealed that the C-DRS-15 was supported by a modified three-factor structure in our Chinese sample (RMSEA = .06, CFI = .94, TLI = .92, and SRMR = .06). The reliability (Cronbach's α coefficient = .78) and validity were satisfactory. Total resilience score was negatively correlated with depression (p < .001), with non-depressed women scoring higher on the C-DRS-15. CONCLUSIONS: The C-DRS-15 was demonstrated to be a reliable and valid measurement to assess hardiness in Chinese women.


Assuntos
Psicometria , Resiliência Psicológica , Inquéritos e Questionários/normas , Adulto , Povo Asiático , Comparação Transcultural , Depressão , Análise Fatorial , Feminino , Hong Kong , Humanos , Transtornos Mentais , Pessoa de Meia-Idade , Qualidade de Vida , Reprodutibilidade dos Testes , Resiliência Psicológica/classificação , Adulto Jovem
19.
BMC Womens Health ; 14: 70, 2014 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-24886374

RESUMO

BACKGROUND: Although intimate partner sexual aggression has been shown to be associated with adverse mental health outcomes, there is scant information about sexual aggression in Chinese intimate relationships in general and about its mental health impact in particular. This article aimed to investigate sexual aggression in Chinese intimate relationships, including the use of force or threat of force and non-physical coercive tactics in unwanted sex. METHODS: The quantitative and qualitative data used in this paper were drawn from a prospective cohort study conducted in Hong Kong between September 2010 and September 2012. A total of 745 Chinese women aged 18 or older who had been in an intimate relationship in the preceding 12 months were recruited from sites in all districts of Hong Kong. Multiple logistic regression analysis, ordinary linear regression, and t-tests were used in quantitative analysis. Directed content analysis was used to analyze the transcripts of 59 women who revealed experiences of intimate partner sexual aggression in individual in-depth interviews. RESULTS: Of the 745 Chinese women in the study, 348 (46.7%) had experienced intimate partner physical violence in the past year, and 179 (24%) had experienced intimate partner physical violence and sexual aggression in the past year. Intimate partner sexual aggression significantly predicted PTSD and depressive symptoms after controlling for intimate partner physical violence. Among the 179 women reporting intimate partner physical violence and sexual coercion in the past year, 75 indicated that their partners used force or threat of force to make them have sex, and 104 of them reported that they gave in to sex because of non-physical coercive tactics used by their partners. Qualitative data revealed a variety of non-physical coercive tactics with different degrees of subtlety used to coerce women into unwanted sex with their partners. Chinese women experiencing physically forced sex had significantly more depressive symptoms and PTSD symptoms. CONCLUSIONS: Our findings indicate that sexual aggression in Chinese intimate relationships has specific mental health consequences over and above those associated with physical violence. Assessment of partner violence in Chinese relationships should include screening for sexual aggression in order to provide appropriate interventions. TRIAL REGISTRATION: ClinicalTrials gov NCT01206192.


Assuntos
Coerção , Depressão/epidemiologia , Delitos Sexuais/estatística & dados numéricos , Maus-Tratos Conjugais/estatística & dados numéricos , Adulto , Agressão/psicologia , Estudos de Casos e Controles , China/epidemiologia , Estudos de Coortes , Depressão/psicologia , Estudos de Avaliação como Assunto , Feminino , Hong Kong/epidemiologia , Humanos , Modelos Lineares , Modelos Logísticos , Pessoa de Meia-Idade , Análise Multivariada , Estudos Prospectivos , Pesquisa Qualitativa , Delitos Sexuais/psicologia , Maus-Tratos Conjugais/psicologia , Inquéritos e Questionários
20.
BMC Complement Altern Med ; 14: 300, 2014 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-25127878

RESUMO

BACKGROUND: Abused women, who suffer from chronic psychological stress, have been shown to have shorter telomeres than never abused women. Telomere shortening is associated with increased risk of cell death, and it is believed that adopting health-promoting behaviors can help to increase the activity of telomerase, an enzyme that counters telomere shortening. Qigong is an ancient Chinese mind-body integration, health-oriented practice designed to enhance the function of qi, an energy that sustains well-being. Therefore, an assessor-blind, randomized, wait-list controlled trial was developed to evaluate the effect of a qigong intervention on telomerase activity (primary objective) and proinflammatory cytokines, perceived stress, perceived coping, and depressive symptoms (secondary objectives) in abused Chinese women. METHODS/DESIGN: A total of 240 Chinese women, aged ≥ 18 years, who have been abused by an intimate partner within the past three years will be recruited from a community setting in Hong Kong and randomized to receive either a qigong intervention or wait-list control condition as follows: the qigong intervention will comprise (i) a 2-hour group qigong training session twice a week for 6 weeks, (ii) a 1-hour follow-up group qigong exercise session once a week for 4 months, and (iii) a 30-minute self-practice qigong exercise session once a day for 5.5 months. The wait-list control group will receive qigong training after the intervention group completes the program. Upon completion of the qigong intervention program, it is expected that abused Chinese women in the intervention group will have higher levels of telomerase activity and perceived coping and lower levels of proinflammatory cytokines, perceived stress, and depressive symptoms than will abused Chinese women in the wait-list control group. DISCUSSION: This study will provide information about the effect of qigong exercise on telomerase activity and chronic psychological stress in abused Chinese women. The findings will inform the design of interventions to relieve the effects of IPV-related psychological stress on health. Also, the concept that health-promoting behaviors could slow down cellular aging might even motivate abused women to change their lifestyles. TRIAL REGISTRATION: Current Controlled Trials NCT02060123. Registered February 6, 2014.


Assuntos
Mulheres Maltratadas , Qigong/métodos , Estresse Psicológico/terapia , Telomerase/sangue , Listas de Espera , Adulto , Feminino , Hong Kong , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Estresse Psicológico/enzimologia , Adulto Jovem
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