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INTRODUCTION: Internationally, there are resilience promotion programs applied to children in residential alterna tive care with favorable results. The application of the resilience promotion program "VOLANTÍN" has shown to be effective in different groups of school-age children, favoring the development of resilience. OBJECTIVE: To describe the results of the implementation of the "VOLANTÍN' program on the level of resilience, self-concept, and emotional symptoms in children aged 7-12 years in resi dential alternative care (foster care). SUBJECTS AND METHOD: descriptive, longitudinal study. The "VO LANTÍN" program was implemented in a sample of 15 foster children between 7-12 years old. The variables measured were the "Escala de Resiliencia Escolar" (ERE), the Piers-Harris Children's Self Concept Scale, the Anxiety Self-report for Children and Adolescents (AANA), and the Children's Depression Inventory (CDI) at the beginning, at the end, and 3 months after the end of the program, and then were analyzed statistically by nonparametric test. RESULTS: At the beginning, the end, and three months after the program implementation, there was a significant increase in the total sco res of ERE (p0.045), subscales "networks-models" (p0.002) and "external resources" (p0.018); and Self-concept (p0.005), subscales "behavior" (p0.045) and "popularity" (p0.03). AANA total scores decreased significantly (p0.004) as well as the subscales "panic/somatic" (p0.025) and "generalized anxiety" (p0.009). CDI scores decreased, but not significantly. CONCLUSION: The application of the resilience promotion program "VOLANTÍN' increased resilience and self-concept scores and decrea sed anxious symptoms in children aged 7-12 years.
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Ansiedade , Depressão , Adolescente , Ansiedade/prevenção & controle , Criança , Depressão/prevenção & controle , Depressão/psicologia , Humanos , Estudos Longitudinais , Autoimagem , AutorrelatoRESUMO
The 2011 Decay Data Evaluation Project (DDEP) evaluation for 147Nd includes recommended absolute emission intensities for the two main gamma-rays at 91.105 (2) keV and 531.016 (22) keV of 0.284 (18) and 0.127 (9) respectively, i.e. with uncertainties of 6.3% and 7.1%. These large uncertainties stem from inconsistencies in the published data and are unfit for modern purposes, since the production of 147Nd is used as an important neutron flux dosimeter. The LNE-LNHB has undertaken new absolute gamma-ray emission intensity measurements. The results of these measurements will be presented, along with a full uncertainty budget, and their effect on the recommended data uncertainties will be discussed.
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In this study, a new analytical procedure based on isotachophoresis (ITP) coupled to a multi collector inductively coupled plasma mass spectrometer named Stop-Flow-ITP-MC-ICPMS is developed for exhaustive and high-precision multi-elemental isotopic characterization. We demonstrate that Stop-Flow-ITP makes it possible to stop the analytes migration several times for a duration compatible with the detector configuration changes without losing the separation performance. With this procedure, isotope ratio measurements of four lanthanides of interest for nuclear applications (Nd, Sm, Eu and Gd) were obtained with a reproducibility better than 0.4% in a single analysis with only 20ng of each element. A nebulization interface between ITP and MC-ICPMS composed of a dual inlet spray chamber and a multiple flow stream valve made it possible to perform isotopic reference standard injections for on-line mass bias correction by the sample standard bracketing approach. The flexibility of the Stop-Flow-ITP-MC-ICPMS procedure opens the way to online determination of isotope ratio measurements of multiple analytes present in a sample in a single analysis.
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A reversed-phase high-performance liquid chromatographic method has been developed to determine paracetamol, caffeine and propyphenazone in a typical tablet formulation with high accuracy and precision. The mobile phase is a linear water-methanol gradient.
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A simple method for measuring angiotensin-converting enzyme activity in human serum was developed. Samples were incubated with hippurylhistidylleucine and the liberated hippuric acid was determined directly by reversed phase ion-pair high-performance liquid chromatography with UV spectrometric detection.
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A rapid and specific high-performance liquid chromatographic assay for the quantitative determination of angiotensin-converting enzyme activity is described. Hippuryl-L-histidyl-L-leucine (Hip-His-Leu) is used as substrate and the released hippuric acid is measured. The procedure is accurate and precise and no extraction is required.
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After preliminary in vitro screening of 15 newly synthesized compounds belonging to the chemical class of N1-(aryliden)-4-pyridinecarboxyamidrazones against Mycobacterium tuberculosis reference strain H37 Rv, we determined the minimum inhibitory concentrations (MICs) of the six most promising chemicals against different species of Mycobacterium and different strains of M. tuberculosis. The agar dilution method was employed against M. gordonae, M. bovis, M. kansasi, M. avium, M. fortuitum and on eighteen different strains of M. tuberculosis, isolated from human bronchial aspirates. The results obtained confirmed that the newly synthesized chemicals possessed a very interesting antitubercular activity, their MICs ranging from 4 micrograms/ml to 16 micrograms/ml.
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Antituberculosos/farmacologia , Mycobacterium tuberculosis/efeitos dos fármacos , Piridinas/farmacologia , Antituberculosos/química , Antituberculosos/classificação , Humanos , Testes de Sensibilidade Microbiana , Mycobacterium tuberculosis/química , Mycobacterium tuberculosis/classificação , Piridinas/química , Especificidade da EspécieRESUMO
After preliminary in vitro screening of 17 newly synthesized compounds belonging to the chemical class of N1-(aryliden)-2-pyridinecarboxyamidrazones, active against Mycobacterium tuberculosis H37Rv, the minimum inhibitory concentrations (MICs) of the ten most promising agents against three clinical isolates were determined by agar dilution. Compounds 12 and 14 were the most active, each inhibiting strain H37Rv at concentrations of 8 microg/ml and having a MIC of 16 microg/ml against the human isolates. The results obtained in this preliminary study confirmed the interesting antitubercular properties of these newly synthesized compounds and allowed us to carry out our investigations over a large number of isolated clinical strains.
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Mycobacterium tuberculosis/efeitos dos fármacos , Piridinas/farmacologia , Humanos , Testes de Sensibilidade MicrobianaRESUMO
A rapid, sensitive and specific reversed phase HPLC method for the simultaneous assay of amiodarone and its major metabolite desethylamiodarone in human serum has been developed. This method is suitable for pharmacokinetic studies and for monitoring of the drug and metabolite concentrations in serum of patients on both short and long-term therapy with amiodarone.
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Amiodarona/análogos & derivados , Amiodarona/sangue , Cromatografia Líquida de Alta Pressão , HumanosRESUMO
A series of 2-arylamino-1,3,4-thiadiazole derivatives was synthesized with the aim to find new antihypertensive compounds. The antihypertensive activity of some of these compounds was examined intraperitoneally in conscious spontaneously hypertensive rats (SHR). The tested compounds showed activity, but none of these possessed a higher potency than the reference substance guanabenz.
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Anti-Hipertensivos/síntese química , Tiadiazóis/síntese química , Animais , Anti-Hipertensivos/administração & dosagem , Pressão Sanguínea/efeitos dos fármacos , Fenômenos Químicos , Química , Frequência Cardíaca/efeitos dos fármacos , Masculino , Ratos , Ratos Endogâmicos SHR , Tiadiazóis/administração & dosagem , Tiadiazóis/farmacologia , Fatores de TempoRESUMO
A series of pyridine-2-carboxamidrazone and quinoline-2-carboxamidrazone derivatives containing the indole moiety was prepared. Some of the synthesized compounds showed an interesting in vitro antimycobacterial activity against a strain of Mycobacterium tuberculosis.
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Antituberculosos/síntese química , Mycobacterium tuberculosis/efeitos dos fármacos , Antituberculosos/farmacologia , Testes de Sensibilidade MicrobianaRESUMO
A series of 5-substituted 2-arylamino-1,3,4-thiadiazole derivatives was prepared. The antimicrobial activity of these compounds against some strains of bacteria and a strain of Candida albicans was determined, together with that of the corresponding thiosemicarbazone derivatives, which are intermediates in the synthetical procedure.
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Anti-Infecciosos/síntese química , Bactérias/efeitos dos fármacos , Tiadiazóis/síntese química , Antibacterianos , Anti-Infecciosos/farmacologia , Antifúngicos/síntese química , Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Escherichia coli/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Tiadiazóis/farmacologiaRESUMO
6-[(Arylmethylenamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis.
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Antituberculosos/farmacologia , Triazinas/farmacologia , Antituberculosos/síntese química , Antituberculosos/química , Estrutura Molecular , Mycobacterium avium/efeitos dos fármacos , Mycobacterium tuberculosis/efeitos dos fármacos , Triazinas/síntese química , Triazinas/químicaRESUMO
[5-(Pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid arylidene-hydrazide derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed a feable activity against a strain of Mycobacterium tuberculosis and a strain of Mycobacterium avium.
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Antibacterianos/síntese química , Tiadiazóis/síntese química , Antibacterianos/química , Antibacterianos/farmacologia , Testes de Sensibilidade Microbiana , Mycobacterium/efeitos dos fármacos , Relação Estrutura-Atividade , Tiadiazóis/química , Tiadiazóis/farmacologiaRESUMO
5-Aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. The compounds showed an interesting activity against a strain of Mycobacterium tuberculosis and a human strain of M. tuberculosis H4.
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Antibacterianos/síntese química , Antituberculosos/síntese química , Pirazóis/síntese química , Antibacterianos/química , Antibacterianos/farmacologia , Antituberculosos/química , Antituberculosos/farmacologia , Humanos , Testes de Sensibilidade Microbiana , Mycobacterium tuberculosis/efeitos dos fármacos , Mycobacterium tuberculosis/isolamento & purificação , Pirazóis/química , Pirazóis/farmacologia , Relação Estrutura-AtividadeRESUMO
N1-[1-[3-aryl-1-(pyridin-2,3-, and 4-yl)-3-oxo[propyl]-2- pyridinecarboxamidrazone derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis and a strain of Mycobacterium avium.
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Antibacterianos/farmacologia , Mycobacterium avium/efeitos dos fármacos , Mycobacterium tuberculosis/efeitos dos fármacos , Piridinas/síntese química , Piridinas/farmacologia , Testes de Sensibilidade Microbiana , Piridinas/química , Análise EspectralRESUMO
A series of N1-aryliden-4-pyridinecarboxyamidrazone derivatives was prepared. Some of the synthesized compounds showed interesting in vitro antimycobacterial activity against some strains of Mycobacterium and clinical isolates of Mycobacterium tuberculosis.
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Mycobacterium/efeitos dos fármacos , Piridinas/síntese química , Antituberculosos/síntese química , Antituberculosos/farmacologia , Resistência Microbiana a Medicamentos , Humanos , Testes de Sensibilidade Microbiana , Mycobacterium avium/efeitos dos fármacos , Mycobacterium tuberculosis/efeitos dos fármacos , Piridinas/farmacologiaRESUMO
The synthesis and in vitro antifungal activity of some pyridincarboxyamidrazone derivatives are described. 2-pyridincarboxyamidrazone derivative (IIa) in comparison with miconazole showed an interesting even if low antimycotic activity.
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Amidinas/farmacologia , Antifúngicos/síntese química , Piridinas/farmacologia , Amidinas/síntese química , Aspergillus niger/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Fenômenos Químicos , Química , Meios de Cultura , Fungos/efeitos dos fármacos , Furanos/síntese química , Furanos/farmacologia , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Piridinas/síntese química , Tiofenos/síntese química , Tiofenos/farmacologia , Trichophyton/efeitos dos fármacosRESUMO
A series of N1-aryliden-2-pyridincarboxyamidrazone derivatives was prepared. Some of the synthesized compounds showed interesting in vitro antimycobacterial activity against some strains of Mycobacterium and clinical isolates of Mycobacterium tuberculosis.