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1.
Med Oral Patol Oral Cir Bucal ; 27(3): e198-e204, 2022 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-35420069

RESUMO

BACKGROUND: Odontogenic tumors (OTs) are considered important among oral lesions because of their clinicopathological heterogeneity and variable biological behavior. The purpose of this retrospective cross-sectional study was to evaluate the frequency and distribution of different types of odontogenic tumors based on the current 2017 WHO Classification of Head and Neck Tumors over a period of 5 years. This was achieved by reviewing the records of Cairo's educational hospitals and institutions and comparing the results with findings in the literature. MATERIAL AND METHODS: The records of patients diagnosed with odontogenic tumors were obtained from six educational hospitals and a single institute in Cairo which included: Oral and Maxillofacial Pathology Department, Faculty of Dentistry, Cairo University; General Pathology Department, Faculty of Medicine, Cairo University; Oral Pathology Department, Faculty of Dentistry, Ain Shams University; Eldemerdash Hospital, Ain Shams University; El-Sayed Galal Hospital, Al-Azhar University; Ahmed Maher Teaching Hospital and National Cancer Institute. These records were reviewed over a 5-year (2014-2018) period and the odontogenic tumors were investigated for frequency, age, gender and site. The data were recorded, then analyzed using SPSS software. RESULTS: Intraosseous (central) odontogenic tumors constituted 2.56% of all 8974 registered oral and maxillofacial biopsies. A total of 230 cases of OTs were collected and reviewed. Of these, 97.8% were benign and 2.17% were malignant. The mandible was the most commonly affected anatomic location. Ameloblastoma, with a predilection for the posterior mandible, was the most frequent odontogenic tumor (55.65%), followed by cemento-ossifying fibroma (14.78%) and odontoma (9.13%). Females were more commonly affected than males. Most of the patients were in the third and fourth decades of life. There were no peripheral odontogenic tumors diagnosed in this period. CONCLUSIONS: Some similarities and differences between our findings and those of previous studies of various populations were witnessed. OTs may greatly diverge according to the version of the classification used and by the sample size of the study. Retrospective analysis of the relative frequency of OTs in different countries will be helpful in enhancing the understanding of OTs, which is important for both oral maxillofacial surgeons and pathologists.


Assuntos
Ameloblastoma , Tumores Odontogênicos , Ameloblastoma/patologia , Estudos Transversais , Egito/epidemiologia , Feminino , Humanos , Masculino , Tumores Odontogênicos/patologia , Compostos Orgânicos , Estudos Retrospectivos
2.
Ann Surg Oncol ; 21(2): 527-32, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24242676

RESUMO

BACKGROUND: The treatment of anal cancer in human immunodeficiency virus (HIV) patients-as in the general population-is primarily with chemoradiotherapy (CRT), and abdominoperineal resection of residual or recurrent primary disease. The aim of this study was to evaluate the extent of residual primary disease and local recurrence as well as the outcome of salvage surgery after CRT for anal carcinoma in HIV-positive individuals. METHODS: We retrospectively studied HIV-positive anal carcinoma patients treated between February 1989 and November 2012 in a specialist London unit. Extent of residual primary disease, local recurrence after CRT, postoperative complications, and survival after salvage surgery were evaluated. RESULTS: Complete response was experienced in 44 of 53 (83%) of HIV patients treated with CRT for anal carcinoma. One patient (2.3%) developed local recurrence. Nine patients (eight residual primary disease after CRT and one local recurrence) underwent salvage surgery after CRT. There were no perioperative deaths, and perioperative CD4 counts were sustained. Complications occurred in five patients (55%). Median interval to complete perineal healing was 4 months (range 2-11 months), and median hospital stay was 29 days. Survival (median 16 months) was 25% at 2 years from salvage surgery. CONCLUSIONS: Results in HIV-positive patients receiving highly active antiretroviral therapy (HAART) suggest that loss of HIV sensitivity to HAART can be avoided, but that there is increased postoperative morbidity that may be related to HIV disease. Survival was comparable to that for salvage therapy after optimal CRT in non-HIV anal carcinoma patients.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias do Ânus/cirurgia , Carcinoma de Células Escamosas/cirurgia , Quimiorradioterapia , Infecções por HIV/complicações , Recidiva Local de Neoplasia/cirurgia , Terapia de Salvação , Adulto , Idoso , Terapia Antirretroviral de Alta Atividade/efeitos adversos , Neoplasias do Ânus/induzido quimicamente , Neoplasias do Ânus/mortalidade , Neoplasias do Ânus/terapia , Carcinoma de Células Escamosas/induzido quimicamente , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/terapia , Terapia Combinada , Feminino , Seguimentos , HIV/patogenicidade , Infecções por HIV/tratamento farmacológico , Infecções por HIV/virologia , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/induzido quimicamente , Recidiva Local de Neoplasia/mortalidade , Recidiva Local de Neoplasia/terapia , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida
3.
Heliyon ; 9(6): e16601, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37274649

RESUMO

Magnetic spinel ferrite materials offer various applications in biomedical, water treatment, and industrial electronic devices, which has sparked a lot of attention. This review focuses on the synthesis, characterization, and applications of spinel ferrites in a variety of fields, particularly spinel ferrites with doping. Spinel ferrites nanoparticles doped with the elements have remarkable electrical and magnetic properties, allowing them to be used in a wide range of applications such as magnetic fields, microwave absorbers, and biomedicine. Furthermore, the physical properties of spinel ferrites can be modified by substituting metallic atoms, resulting in improved performance. The most recent and noteworthy applications of magnetic ferrite nanoparticles are reviewed and discussed in this review. This review goes over the synthesis, doping and applications of different types of metal ferrite nanoparticles, as well as views on how to choose the appropriate magnetic ferrites based on the intended application.

4.
J Adv Res ; 48: 157-173, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-36049735

RESUMO

INTRODUCTION: Mathematical modelling is a rapidly expanding field that offers new and interesting opportunities for both mathematicians and biologists. Concerning COVID-19, this powerful tool may help humans to prevent the spread of this disease, which has affected the livelihood of all people badly. OBJECTIVES: The main objective of this research is to explore an efficient mathematical model for the investigation of COVID-19 dynamics in a generalized fractional framework. METHODS: The new model in this paper is formulated in the Caputo sense, employs a nonlinear time-varying transmission rate, and consists of ten population classes including susceptible, infected, diagnosed, ailing, recognized, infected real, threatened, diagnosed recovered, healed, and extinct people. The existence of a unique solution is explored for the new model, and the associated dynamical behaviours are discussed in terms of equilibrium points, invariant region, local and global stability, and basic reproduction number. To implement the proposed model numerically, an efficient approximation scheme is employed by the combination of Laplace transform and a successive substitution approach; besides, the corresponding convergence analysis is also investigated. RESULTS: Numerical simulations are reported for various fractional orders, and simulation results are compared with a real case of COVID-19 pandemic in Italy. By using these comparisons between the simulated and measured data, we find the best value of the fractional order with minimum absolute and relative errors. Also, the impact of different parameters on the spread of viral infection is analyzed and studied. CONCLUSION: According to the comparative results with real data, we justify the use of fractional concepts in the mathematical modelling, for the new non-integer formalism simulates the reality more precisely than the classical framework.


Assuntos
COVID-19 , Pandemias , Humanos , Número Básico de Reprodução , Simulação por Computador , Existencialismo
5.
Ann Oncol ; 23(1): 141-147, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21444358

RESUMO

BACKGROUND: Despite the advent of highly active antiretroviral therapy, anal cancer remains a significant health problem in human immunodeficiency virus (HIV) patients. We present the clinical features and treatment outcomes of anal cancer in 60 HIV-positive patients over a 20-year period. PATIENTS AND METHODS: A prospective database of all HIV-positive individuals managed in a specialist unit since 1986 includes 11 112 patients (71 687 person-years of follow-up). Sixty patients with anal cancer were identified. Their clinicopathological and treatment details were analysed. RESULTS: At anal cancer diagnosis, the mean age was 44 years (range: 28-75 years) and the median CD4 cell count was 305 mm(-3) (range: 16-1252 mm(-3)). Fifty (83%) had chemoradiotherapy (CRT). Forty-six (92%) responded, of whom 10 (22%) subsequently relapsed with locoregional (70%), metastatic disease (10%) or both (20%). The overall 5-year survival is 65% (95% confidence interval 51% to 78%). The median CD4 count fell from 289 mm(-3) before CRT to 132 mm(-3) after 3 months and to 189 mm(-3) after 1 year (P<0.05). Six patients in remission of anal cancer died of acquired immunodeficiency syndrome defining illnesses. CONCLUSIONS: The management of anal cancer with CRT achieves similar outcomes as the general population. CRT is associated with significant prolonged CD4 suppression that may contribute to late deaths of patients in remission.


Assuntos
Neoplasias do Ânus/terapia , Linfócitos T CD4-Positivos/efeitos dos fármacos , Linfócitos T CD4-Positivos/efeitos da radiação , Quimiorradioterapia , Infecções por HIV/complicações , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias do Ânus/mortalidade , Neoplasias do Ânus/virologia , Contagem de Linfócito CD4 , Capecitabina , Sobrevivência Celular/efeitos da radiação , Quimiorradioterapia/efeitos adversos , Quimiorradioterapia/métodos , Desoxicitidina/administração & dosagem , Desoxicitidina/efeitos adversos , Desoxicitidina/análogos & derivados , Feminino , Fluoruracila/administração & dosagem , Fluoruracila/efeitos adversos , Fluoruracila/análogos & derivados , Infecções por HIV/mortalidade , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Mitomicina/administração & dosagem , Mitomicina/efeitos adversos
6.
Acta Crystallogr E Crystallogr Commun ; 76(Pt 7): 1092-1095, 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-32695458

RESUMO

In the title compound, C27H28N2OS, the naphthalene unit is planar to within 0.015 (2) Šand makes a dihedral angle of 14.24 (16)° with the thia-zole ring. The anisole ring is inclined to the thia-zole ring by a dihedral angle of 13.18 (23)°. The torsion angle between the heptyl chain and the anisole ring is 61.1 (4)°. These dihedral and torsion angles render the mol-ecule non-planar. In the crystal, mol-ecules are linked by C-H⋯π inter-actions, forming zigzag chains that propagate parallel to the b axis. The roles of the various inter-molecular inter-actions in the crystal packing were clarified by Hirshfeld surface analysis; the most important contributions are from H⋯H (51.5%) and C⋯H/H⋯C (31.8%) contacts.

7.
Acta Crystallogr E Crystallogr Commun ; 76(Pt 6): 920-923, 2020 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-32523764

RESUMO

The asymmetric unit of the title compound, C23H20N2OS, contains one slightly bent mol-ecule. The naphthalene ring system and the thia-zole ring are twisted with respect to each other, making a dihedral angle of 13.69 (10)°; the anisole ring is inclined to the plane of the naphthalene ring system, the dihedral angle being 14.22 (12)°. In the crystal structure, mol-ecules are linked by C-H⋯π inter-actions, resulting in the formation of sheets parallel to (100). Within the sheets, very weak π-π stacking inter-actions lead to additional stabilization. Hirshfeld surface analysis and fingerprint plots reveal that the cohesion in the crystal structure is dominated by H⋯H (42.5%) and C⋯H/H⋯C (37.2%) contacts.

8.
Acta Crystallogr E Crystallogr Commun ; 76(Pt 10): 1591-1594, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33117570

RESUMO

The title compound, C17H16N2OS, was synthesized by a condensation reaction between 2-amino benzo-thia-zole and 4-N-propoxybenzaldehyde. The benzo[d]thia-zole ring system is nearly planar (r.m.s. deviation 0.0088 Å) and makes a dihedral angle of 3.804 (12)° with the phenyl ring. The configuration about the C=N double bond is E. In the crystal structure, pairs of C-H⋯N hydrogen bonds and C-H⋯π inter-actions link the mol-ecules into inversion dimers with an R 2 2(16) ring motif. These dimers are additionally linked by weak π-π stacking inter-actions between the phenyl rings, leading to a layered arrangement parallel to (010). Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the packing arrangement are from H⋯H (47.9%) and C⋯H/H⋯C (25.6%) inter-actions.

9.
Braz J Biol ; 80(3): 565-573, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31644650

RESUMO

Due to increased number of herbicide resistant weeds, it is needed to explore the allelopathic potential of plants as an alternative. The research was conducted to investigate allelopathic effects of Carica papaya L. leaf powder and aqueous extract on seeds as well as pre-germinated seeds of Avena fatua L., Helianthus annuus L., Rumex dentatus L., Zea mays L. and Triticum aestivum L. on filter paper and soil in Weed Management Program Laboratory, Department of Plant and Environmental Protection at PARC Institute of Advanced Studies in Agriculture, National Agriculture Research Centre, Islamabad, Pakistan. Germination percentage (%), radicle length (cm) and plumule length (cm) were parameters observed for 'Plant leaf powder bioassay' and 'Aqueous extract method'. Most significant growth inhibition was observed in A. fatua seedlings in filter paper method. A. fatua radicle length was reduced by C. papaya aqueous extract (80%) and leaf powder (89%) bioassays. Plumule length was reduced under the influence of aqueous extract (57-73%) and powdered material (59-77%). The inhibitory effects on other test species were in sequence of H. annuus followed by Z. mays and R. dentatus. The aqueous extract showed non-significant effect on wheat seed germination, radicle and plumule growth. It is suggested that C. papaya aqueous extract can be used as source of weed management in wheat crop.


Assuntos
Carica , Germinação , Paquistão , Extratos Vegetais , Folhas de Planta , Sementes
10.
Surgeon ; 5(1): 58-9, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17313131

RESUMO

We report a patient in whom the diagnoses of the syndrome of inappropriate anti-diuretic hormone secretion (SIADH) and gastric carcinoma were made concurrently. After a gastrectomy, there was resolution of the electrolyte disturbances. This represents the third reported case of this association in the English language literature.


Assuntos
Adenocarcinoma/complicações , Síndrome de Secreção Inadequada de HAD/etiologia , Neoplasias Gástricas/complicações , Adenocarcinoma/diagnóstico , Adenocarcinoma/cirurgia , Idoso , Biópsia , Diagnóstico Diferencial , Seguimentos , Gastrectomia/métodos , Gastroscopia , Humanos , Síndrome de Secreção Inadequada de HAD/diagnóstico , Masculino , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/cirurgia , Tomografia Computadorizada por Raios X
11.
Eur J Surg Oncol ; 42(6): 813-6, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27012999

RESUMO

INTRODUCTION: Anal cancer accounts for a small percentage of colorectal malignancies. Early stage (T1N0M0) cancers of the anal verge have been treated with local surgical excision alone in individuals without human immunodeficiency virus (HIV) infection. The risk of anal cancer is higher in people living with HIV (PLWH). We present results of the outcomes of T1 anal verge cancers treated by local excision only in a series of PLWH. METHODS: Demographic and clinicopathological data was prospectively collected from all HIV positive individuals with anal cancer, treated between 1986 and 2015. The date from anal cancer diagnosis until the date of the last follow up were collected. RESULTS: Fifteen patients had T1N0M0 cancer of the anal verge from a total of 92 patients with HIV-associated anal cancer. The mean age was 49 years (range 36-57). The average age of HIV diagnosis was 35 years (range 19-48) and four patients had a diagnosis of AIDS prior to the diagnosis of anal cancer. All patients were surgically managed with complete local excision of the tumour. There were no complications or need for any adjuvant therapy. No patients have relapsed and at a median follow up of 4 years (range 3-15), the overall survival was 100%. CONCLUSION: Surgical resection for early stage anal verge cancers is an effective strategy in PLWH. Increasing awareness of anal cancer and anoscopy surveillance in PLWH will hopefully continue to identify anal cancers at an early stage that are amenable to minimally invasive surgical management.


Assuntos
Canal Anal/cirurgia , Neoplasias do Ânus/patologia , Neoplasias do Ânus/cirurgia , Infecções por HIV/complicações , Adulto , Canal Anal/patologia , Neoplasias do Ânus/complicações , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos , Estadiamento de Neoplasias , Estudos Prospectivos , Resultado do Tratamento
12.
Dalton Trans ; 44(28): 12796-803, 2015 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-26091252

RESUMO

A giant magnetocaloric effect induced by sodium-deficiency in a La0.8Na0.2-x□xMnO3 (0.00 ≤ x ≤ 0.15) polycrystalline sample is reported in the present research work. The ability to tune the temperature transition close to room temperature is revealed to be possible by changing the sodium-deficiency content as well. All samples were synthesized using solid-solid reaction. X-ray diffraction and magnetization measurements were performed to investigate their crystallographic structure and magnetocaloric properties. A rhombohedral structure with the R3[combining macron]c space group is deduced from pattern diffraction refinement of all samples. A second-order magnetic phase transition from the ferromagnetic to the paramagnetic state at the Curie temperature (Tc) is observed. Such a Tc decreased from 335 to 260 K when the sodium deficiency rate increased. Besides, the magnetic entropy change and the related Relative Cooling Power (RCP) values, sensitive to sodium-deficiency, were estimated. The magnetic entropy change ranges increased from 2.38 J kg(-1) K(-1) to 3.48 J kg(-1) K(-1) under a magnetic field of 2 T, whereas the RCP varied from 210 to 235 J kg(-1) under an applied magnetic field of 5 T, when x increased from 0.00 to 0.15. The comparison of the values reported in the reference Gd material underlines that the proposed oxide material has substantial advantages for magnetic refrigeration.

13.
Braz. j. biol ; 80(3): 565-573, July-Sept. 2020. tab
Artigo em Inglês | LILACS | ID: biblio-1132399

RESUMO

Abstract Due to increased number of herbicide resistant weeds, it is needed to explore the allelopathic potential of plants as an alternative. The research was conducted to investigate allelopathic effects of Carica papaya L. leaf powder and aqueous extract on seeds as well as pre-germinated seeds of Avena fatua L., Helianthus annuus L., Rumex dentatus L., Zea mays L. and Triticum aestivum L. on filter paper and soil in Weed Management Program Laboratory, Department of Plant and Environmental Protection at PARC Institute of Advanced Studies in Agriculture, National Agriculture Research Centre, Islamabad, Pakistan. Germination percentage (%), radicle length (cm) and plumule length (cm) were parameters observed for 'Plant leaf powder bioassay' and 'Aqueous extract method'. Most significant growth inhibition was observed in A. fatua seedlings in filter paper method. A. fatua radicle length was reduced by C. papaya aqueous extract (80%) and leaf powder (89%) bioassays. Plumule length was reduced under the influence of aqueous extract (57-73%) and powdered material (59-77%). The inhibitory effects on other test species were in sequence of H. annuus followed by Z. mays and R. dentatus. The aqueous extract showed non-significant effect on wheat seed germination, radicle and plumule growth. It is suggested that C. papaya aqueous extract can be used as source of weed management in wheat crop.


Resumo Devido ao aumento do número de ervas daninhas resistentes aos herbicidas, é necessário explorar o potencial alelopático das plantas como uma alternativa. A pesquisa foi conduzida com o objetivo de investigar os efeitos alelopáticos do pó foliar de Carica papaya e do extrato aquoso das sementes, bem como das sementes pré-germinadas de Avena fatua, Helianthus annuus, Rumex dentatus, Zea mays e Triticum aestivum em papel de filtro e solo no Laboratório do Programa de Manejo de Ervas Daninhas, Departamento de Plantas e Proteção Ambiental do Instituto PARC de Estudos Avançados em Agricultura, Centro Nacional de Pesquisa Agrícola, Islamabad, Paquistão. A porcentagem de germinação (%), o comprimento radicular e o comprimento da plúmula (cm) foram os parâmetros observados para o 'Bioensaio de Pó de Folha de Planta' e o 'Método de Extração Aquoso'. A maior inibição do crescimento foi observada em mudas de A. fatua no método de papel de filtro. O comprimento radicular de A. fatua foi reduzido com os extratos aquosos de C. papaya (80%) e pó de folhas (89%). O comprimento das plúmulas foi reduzido sob a influência do extrato aquoso (57-73%) e material em pó (59-77%). Os efeitos inibitórios em outras espécies-teste foram na sequência de H. annuus seguido por Z. mays e R. dentatus. O extrato aquoso apresentou efeito não significativo na germinação das sementes de trigo, nos crescimentos radiculares e das plúmulas. Sugere-se que o extrato aquoso de C. papaya pode ser utilizado como fonte de manejo de plantas daninhas na cultura do trigo.


Assuntos
Carica , Paquistão , Sementes , Extratos Vegetais , Folhas de Planta , Germinação
14.
J Smooth Muscle Res ; 37(5-6): 123-35, 2001 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12126039

RESUMO

In order to understand the pathology of varicose veins, we prospectively collected a total of 23 vein specimens both from the normal proximal thigh long saphenous vein (LSV) in 3 young trauma patients and from the unstripped proximal LSV near the sapheno-femoral junction and the distal calf blowouts in 10 primary varicose veins patients. Ultra-thin sections were examined under the transmission electron microscope (TEM). Compared with the normal control LSV, varicose vein sections showed increase in the diameter of the lumen, hypertrophy of the wall and elongation and invagination of the intima. Smooth muscle cells (SMCS) lost their normal fusiform shape and were widely separated by increased amounts of extra-cellular collagen fibers. The cells underwent marked degeneration, vacuolization and disintegration into fiber-like material and small separated fragments. SMCs were seen in the subintimal tissue and some of them were lost into tile lumen. SMCs also showed marked phagocytic activity, engulfing not only collagen and elastic fibers, but also other smooth muscle cells. Although these changes were more marked and advanced in the distal calf blowouts, they were also present in the proximal, clinically non-dilated LSV. In conclusion, SMCs of varicose veins show severe degeneration in both the distal calf blowouts and the proximal, clinically non-varicose LSV. It appears that they both form and phagocytose collagen and elastic fibers and play a major role in the pathogenesis of varicose veins.


Assuntos
Músculo Liso Vascular/ultraestrutura , Veia Safena/ultraestrutura , Varizes/patologia , Adulto , Feminino , Humanos , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Músculo Liso Vascular/fisiologia , Fagocitose
15.
Pathology ; 31(2): 152-7, 1999 May.
Artigo em Inglês | MEDLINE | ID: mdl-10399172

RESUMO

An electron microscopic (EM) description of mucoid degeneration of the brachial artery in a 67 year old man is presented. In this case, the affected artery showed mucoid degeneration of the intima and media circumferentially, dissecting and destroying the muscle fibres. Ultrastructurally, mucoid degenerating muscle cells showed numerous large mucin-containing vesicles in the cytoplasm. Cells were widely separated by large accumulation of mucoid material, which appeared to penetrate the extracellular collagen fibre bundles. Most of the nuclei of the smooth muscle cells displayed typical necrotic changes undergoing dissolution or having already broken up into discrete fragments. This case of intimo-medial degeneration (IMMD) suggests that the condition could arise spontaneously anywhere in the inner coats of the arterial system away from the vessels that are close to synovial joints. This is a rare presentation of IMMD of arteries, which has been described mainly in the aorta and its major branches.


Assuntos
Arteriopatias Oclusivas/patologia , Artéria Braquial/ultraestrutura , Muco/metabolismo , Idoso , Aneurisma/complicações , Aneurisma/metabolismo , Aneurisma/patologia , Arteriopatias Oclusivas/diagnóstico por imagem , Arteriopatias Oclusivas/metabolismo , Artéria Braquial/diagnóstico por imagem , Artéria Braquial/metabolismo , Artéria Braquial/patologia , Embolia/etiologia , Antebraço , Mãos , Humanos , Masculino , Microscopia Eletrônica , Radiografia , Túnica Íntima/metabolismo , Túnica Íntima/patologia , Túnica Média/metabolismo , Túnica Média/patologia
16.
Int Angiol ; 21(4): 337-43, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12518113

RESUMO

BACKGROUND: The resistance to stretch and the elasticity of the vein wall depend on the collagen and elastic fibers, respectively. Contradicting evidence exists, however, on the connective tissue concentration in varicose veins. METHODS: A prospective, comparative study was conducted at Asir Central Hospital and the College of Medicine in Abha, Saudi Arabia. Twenty-three vein specimens collected from both the proximal thigh long saphenous vein (LSV) and the distal calf blowouts in 10 primary varicose vein patients and from the normal, proximal thigh LSV in 3 young vascular trauma patients were examined. Paraffin sections stained with hematoxylin and eosin, Verhoeff von Gieson (VVG) and Masson's Trichrome stains were examined under the light microscope. Ultra thin sections were examined under the transmission electron microscope (TEM). RESULTS: Compared with the normal control LSV, varicose vein sections showed increased diameter of the lumen and hypertrophy of the wall, mainly of the intima, due to increased amounts of collagen fibers. This marked fibrous infiltration disrupted the normal palisade arrangement of the intimal and the regular sheet-like arrangement of the medial smooth muscle cells. Collagen fibers also lost their normal pattern and showed abnormal forms. Elastic fibers lost their regular laminar arrangement and formed clumps or scattered fragments. CONCLUSIONS: Varicose veins showed increased collagenosis and distortion of the elastic fibers. The presence of abnormal collagen to elastin ratio and the loss of the regular collagen/elastic lattice of the vein wall may play a major role in the pathogenesis of varicose veins.


Assuntos
Colágeno/ultraestrutura , Elastina/ultraestrutura , Varizes/patologia , Adolescente , Adulto , Colágeno/fisiologia , Elasticidade , Elastina/fisiologia , Endotélio Vascular/fisiopatologia , Endotélio Vascular/ultraestrutura , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Miócitos de Músculo Liso/fisiologia , Miócitos de Músculo Liso/ultraestrutura , Estudos Prospectivos , Veia Safena/fisiopatologia , Veia Safena/ultraestrutura , Varizes/fisiopatologia
17.
Int Angiol ; 22(2): 188-93, 2003 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12865886

RESUMO

AIM: Vein wall distensibility is controlled by collagen, elastin and smooth muscle cells. However, contradicting evidence exists on the connective tissue concentration and smooth muscle pathology in varicose veins. METHODS: To study the pathological changes in the wall of varicose veins at different levels, we collected a total of 49 vein specimens from 19 patients at Asir Central Hospital, Abha, Saudi Arabia, during the period from March to October 1997. Three young trauma patients underwent repair of their arterial injuries using the thigh long saphenous vein (LSV) and 16 varicose vein patients underwent stripping of their LSV and avulsion of their distal calf varicosities. In the trauma patients, specimens were collected from the proximal thigh LSV while in the varicose vein patients, specimens were collected from both the groin and mid-thigh LSV and the distal calf varicosities. Specimens were stained with Hematoxylin & Eosin, Masson's Trichrome and von Gieson (VG) stains for examination under the light microscope. RESULTS: Compared with the normal LSV, all varicose vein sections showed marked intimal hypertrophy due fibrous tissue infiltration, localized thinning of the muscle layer and loss of both the intimal and medial smooth muscle cells (SMCs). Elastic fibers were deficient and scattered with loss of the normal elastin/collagen lattice network and decrease in both the muscle/collagen and elastin/collagen ratios. CONCLUSION: In conclusion, we propose that dilatation and distensibility of the vein wall under normal and increased venous pressure is due to deficiency in smooth muscle cells and elastic fibers and disproportionate increase in fibrous tissue.


Assuntos
Varizes/patologia , Adolescente , Adulto , Endotélio Vascular/patologia , Feminino , Veia Femoral/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Liso Vascular/irrigação sanguínea , Músculo Liso Vascular/citologia , Músculo Liso Vascular/patologia , Miócitos de Músculo Liso/patologia , Estudos Prospectivos , Veia Safena/patologia , Arábia Saudita , Índice de Gravidade de Doença , Túnica Íntima/citologia , Túnica Íntima/patologia
18.
East Afr Med J ; 75(3): 188-91, 1998 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9640821

RESUMO

Recurrence of varicose veins after treatment has been reported as being between 7% and 65%. During the five month period from August to December 1993, 400 operations on 265 patients were performed for varicose vein disease. Of these, 53 patients had presented with recurrent vein disease in 72 limbs (18%). All patients underwent Duplex scanning of their deep and superficial systems and sites of venous incompetence were identified. The sapheno-femoral junction (SFJ) was found to be incompetent in 52 limbs, of which 31 had previously undergone flush ligation. Sapheno-popliteal junction (SPJ) was incompetent in 33 limbs, while the long saphenous vein (LSV) was found to be incompetent in 67 cases. There were no major complications in this group. Minor complications occurred in 10 cases (14%), mainly in the form of thigh paraesthesia. The more common causes of recurrent disease have been identified and therefore, it should be possible to reduce its incidence. Duplex scanning is essential for any unit dealing with recurrence.


Assuntos
Varizes/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Feminino , Seguimentos , Humanos , Ligadura , Masculino , Pessoa de Meia-Idade , Recidiva , Reoperação/estatística & dados numéricos , Escleroterapia , Ultrassonografia Doppler Dupla , Varizes/diagnóstico por imagem
19.
Afr J Med Med Sci ; 31(3): 219-22, 2002 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12751560

RESUMO

The aim of this prospective, controlled study is to compare the oxygen tension of blood from varicose veins with that from both the antecubital vein of the same patients and the normal long saphenous vein of normal controls at high altitude in Abha (8,000 feet above sea level), Saudi Arabia. Forty-two subjects (21 normal controls and 21 with uncomplicated primary varicose veins) had blood samples taken from 41 normal long saphenous veins and 35 varicose veins near the ankle, respectively (a total of 76 lower limbs). Samples were also taken simultaneously from the right antecubital vein in all the subjects. There was no difference in either oxygen tension (pO2) or saturation (sO2) between blood from varicose veins and blood from normal long saphenous veins. However, in patients with varicose veins, both pO2 and sO2 of varicose veins blood were significantly higher than those of arm venous blood (P = 0.009 and P = 0.018, respectively). In normal subjects, blood from normal long saphenous veins had also significantly higher sO2 (P = 0.001) than that from arm veins, but pO2 was not higher. In conclusion, the theory of arteriovenous communication is poorly founded. There must be other more important explanations for the pathogenesis of varicose veins.


Assuntos
Oxigênio/sangue , Varizes/sangue , Adulto , Altitude , Braço/irrigação sanguínea , Fístula Arteriovenosa/complicações , Gasometria , Estudos de Casos e Controles , Feminino , Humanos , Perna (Membro)/irrigação sanguínea , Masculino , Estudos Prospectivos , Veia Safena , Arábia Saudita , Distribuição Tecidual , Ultrassonografia Doppler , Varizes/diagnóstico por imagem , Varizes/etiologia , Veias
20.
Ann Urol (Paris) ; 29(3): 143-9, 1995.
Artigo em Francês | MEDLINE | ID: mdl-7486850

RESUMO

18 patients with 18 hydatid cyst of kidney, underwent surgical intervention from 1982 to 1994. There were 6 men in the series and 12 women who ranged in age from 7 to 65 years (mean 38 years). Flank pain was the chief complaint (55%). Abdominal mass was detected on physical examination in 38% of cases. Ultrasonographic examination, performed in all cases, made a correct diagnosis in 13 patients (72%). Excretory urogram (IVP), performed in 9 patients, showed signs of benign tumor process. All patients were operated on: the procedures performed included 12 resection of "protruding dome", 1 total nephrectomy, 3 partial pericystectomy, 2 total pericystectomy, 1 total nephrectomy. In postoperative course, there was one death (5.5%) and morbidity was 11%. We conclude that hydatid cyst of kidney still rare but possible in endemic areas; its treatment, usually surgical, still difficult because it should avoid recurrence of hydatic disease without sacrifice of the kidney.


Assuntos
Equinococose/cirurgia , Nefropatias/cirurgia , Adolescente , Adulto , Idoso , Criança , Cistectomia , Equinococose/complicações , Equinococose/diagnóstico , Feminino , Seguimentos , Humanos , Nefropatias/complicações , Nefropatias/diagnóstico , Masculino , Pessoa de Meia-Idade , Nefrectomia , Dor/parasitologia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Urografia
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