Repeatability and validity of astigmatism measurements.

BACKGROUND: As more patients inquire about refractive surgical procedures, the measurement of astigmatism prior to surgery becomes more important in assessing refractive outcome. Knowledge of the repeatability of the astigmatism measurement allows one to distinguish a true change in cylinder power from measurement error. METHODS: Forty adults with structurally normal eyes and refractive errors were evaluated for the repeatability of astigmatic refractive error measures. Noncycloplegic and cycloplegic measurements of refractive astigmatism were made by retinoscopy, subjective refraction, and autorefraction. All measures were made at 2 visits within 2 weeks by the same examiner. Difference versus mean plots and the 95% limits of agreement of each technique determined the repeatability of a measurement and the agreement between the methods of measurement. RESULTS: The most reliable measure of astigmatic refractive error was cycloplegic autorefraction, with 95% limits of agreement of +/- 0.28 D, followed by noncycloplegic autorefraction (+/- 0.35 D) and cycloplegic subjective refraction (+/- 0.44 D). Noncycloplegic retinoscopy was the least reliable astigmatic refractive error measure, with interoccasion 95% limits of agreement of +/- 1.02 D. The most repeatable measurement of cylinder axis was cycloplegic autorefraction; none of the measurements differed by 10 degrees or more. The least repeatable measurement was noncycloplegic retinoscopy; 40% of the measurements differed by 10 degrees or more. CONCLUSION: For studies seeking to measure changes in astigmatism in normal eyes, cycloplegic autorefraction is the method of choice.

Corneal reshaping and myopia progression.

BACKGROUND/AIMS: Anecdotal evidence indicates that corneal reshaping contact lenses may slow myopia progression in children. The purpose of this investigation is to determine whether corneal reshaping contact lenses slow eye growth. METHODS: Forty subjects were fitted with corneal reshaping contact lenses. All subjects were 8 to 11 years and had between -0.75 D and -4.00 D myopia with less than 1.00 D astigmatism. Subjects were age-matched to a soft contact lens wearer from another myopia control study. A-scan ultrasound was performed at baseline and annually for 2 years. RESULTS: Twenty-eight of 40 (70%) subjects wore corneal reshaping contact lenses for 2 years. The refractive error and axial length were similar between the two groups at baseline. The corneal reshaping group had an annual rate of change in axial lengths that was significantly less than the soft contact lens wearers (mean difference in annual change = 0.16 mm, p = 0.0004). Vitreous chamber depth experienced similar changes (mean difference in annual change = 0.10 mm, p = 0.006). CONCLUSION: Results confirm previous reports of slowed eye growth following corneal reshaping contact lens wear.

Validity of surveys reporting myopia, astigmatism, and presbyopia.

Validation of surveys is an important step in establishing the usefulness of questionnaires for gathering information in clinical studies. Often in large studies of refractive error, it is not possible to examine and refract all subjects and their relatives. Therefore, we used 3 methods to evaluate 112 consecutive clinic patients' abilities to report myopia through a survey: (1) The Lay Terms Method asks: "are you nearsighted?"; (2) The Direct Method asks: "are you myopic?"; and (3) The Indirect Method uses a series of questions about the use of eyeglasses and age at first dispensing. Patient responses to the survey before examination were compared to subjective refraction findings at the completion of the eye examination. The Lay Terms Method had the highest sensitivity (0.98) but poor specificity (0.48), and the Direct Method yielded the highest specificity (0.83) but poor sensitivity (0.54). The rate of nonresponse ("don't know") was high (25.9 and 46.4% for the Lay Term and Direct Methods, respectively). The Indirect Method gave both high sensitivity and specificity (0.76 and 0.74, respectively), and only an 8.9% don't know response rate. The survey method that reports the presence or absence of myopia with the best balance of sensitivity and specificity and fewest don't know responses is the Indirect Method, suggesting it is the most suitable of our three approaches for use in clinical studies.

Vision-specific quality of life and modes of refractive error correction.

PURPOSE: Many studies currently use surveys to assess patients' reports of vision-specific quality of life to determine the impact of the disease or the most appropriate mode of treatment. One such instrument, the National Eye Institute Visual Function Questionnaire (NEI-VFQ), was developed to assess vision-related quality of life with respect to emotional well-being and social function as well as difficulty with tasks and symptoms. We administered the NEI-VFQ to 218 subjects free of eye disease to see if the survey was sensitive enough to detect differences in three modes of refractive error correction: spectacles, soft contact lenses, and rigid contact lenses. METHODS: Surveys were administered to 117 rigid contact lens wearers, 51 spectacle wearers, and 50 soft contact lens wearers. Kruskal-Wallis one-way analysis of variance was conducted to determine significant differences in each of the subscales. RESULTS: The Peripheral Vision subscale score (mean +/- SD) was 92.6 +/- 15.2 for the spectacle wearers, 100.0 +/- 0.0 for the soft contact lens wearers, and 98.3 +/- 7.1 for the rigid gas-permeable contact lens wearers; the spectacle wearers' Peripheral Vision score was significantly lower than the other two groups (Wilcoxon rank sum, p < 0.003 for both). The spectacle wearers (96.6 +/- 9.2) also had a significantly lower Dependency subscale score than the rigid contact lens group (99.7 +/- 1.5) (Wilcoxon rank sum, p = 0.001). There were no significant differences between the three groups detected in the mean of any of the other subscale scores. At least 50% of the subjects reported the maximum score for 6 of the 11 subscales. Given our sample size, we have 100% power to detect a difference of 10 points with a SD of 10 at the alpha = 0.05 level. CONCLUSION: The NEI-VFQ is not appropriate for detecting significant differences in vision-related quality of life among spectacle, soft contact lens, and rigid gas-permeable contact lens wearers, primarily due to maximum ratings by many of the subjects.

Visual acuity in contact lens wearers.

PURPOSE: The difference between high- and low-contrast visual acuity provides a sensitive indicator of vision loss in ocular disease; however, the effect of refractive error correction on this difference is still debated. METHODS: High- and low-contrast visual acuity was measured in 116 rigid gas permeable contact lens wearers, 51 spectacle wearers, and 50 soft contact lens wearers with habitual and best correction. Twenty-nine of the soft contact lens wearers reported that they wore disposable contact lenses (discarded on a monthly or more frequent basis), whereas the other 21 soft contact lens wearers wore traditional soft contact lenses. RESULTS: Rigid gas permeable contact lens wearers had statistically worse high-contrast habitual visual acuity than spectacle wearers (Tukey-Kramer, p = 0.0075). Traditional soft contact lens wearers had significantly worse low-contrast visual acuity compared with all other groups (Tukey-Kramer, p < 0.02 for each comparison). Traditional soft contact lens wearers had a significantly larger difference between high- and low-contrast visual acuity with best correction compared with rigid gas permeable wearers (Tukey-Kramer, p = 0.0099). CONCLUSIONS: Rigid gas permeable contact lens wearers had statistically worse habitual high-contrast visual acuity compared with spectacle wearers, but no difference was present under best-corrected conditions. We hypothesize that rigid gas permeable contact lens wearers were not wearing their optimal correction habitually. Traditional soft contact lens wearers had significantly worse low-contrast visual acuity. They also had a larger difference between their best-corrected high- and low-contrast visual acuity scores compared with rigid gas permeable contact lens wearers.

Development of phoria in children.

BACKGROUND: Although the prevalence of phoria in adults is well documented, data are scarce on phoria in children. We present results using modified clinical technique vision screening and data from the Orinda Longitudinal Study of Myopia on a large, population-based sample of nonstrabismic children to document the prevalence of phoria with age. METHODS: We collected cross-sectional (N = 1495) and longitudinal (N = 469) data. Phoria data were collected by cover tests administered by one observer who subjectively classified phoria as orthophoria, esophoria, or exophoria in 2 delta steps. RESULTS: Ninety-seven percent of the children were orthophoric at distance, and there were no significant changes with age. Near phoria showed a more normal distribution, with a 10.8% decrease in the prevalence of exophoria (from 31.8 to 21.0%) and a 5.5% increase in the prevalence of esophoria (from 6.7 to 12.2%) between kindergarten and fifth grade. CONCLUSIONS: Children are typically orthophoric or exophoric at near, but convergent shifts occur with age.

The contact lens and myopia progression (CLAMP) study: design and baseline data.

BACKGROUND: Although previous contact lens myopia control studies indicate that rigid contact lenses slow the progression of myopia in children, they have all suffered from limitations that challenge the significance of their results. The Contact Lens and Myopia Progression (CLAMP) Study addresses the limitations of previous studies and attempts to correct them by implementing alternative Study designs. The CLAMP study also measures all the ocular components to examine the potential mechanism of treatment effect. METHODS: Eligible children were fitted with rigid gas-permeable contact lenses and enrolled in a run-in period to determine whether they were able to adapt to rigid contact lens wear. Subjects who successfully completed the run-in period were randomly assigned to wear rigid contact lenses or soft contact lenses for the remainder of the 3-year study. The primary outcome measure will be the 3-year change in cycloplegic autorefraction; the secondary outcome measures will include the 3-year change in axial length, peripheral autorefraction, crystalline lens curvatures, corneal curvature and thickness, accommodation, and intraocular pressure, which are being measured annually. RESULTS: We examined 148 eligible subjects who participated in the run-in period. Of the 148 eligible subjects, 116 (78.4%) were able to adapt to rigid contact lens wear and were enrolled in the CLAMP Study. The mean age of the participants at the baseline visit was 10.5 years, and 59.5% were girls. At the randomization visit, the mean (+/-SD) spherical equivalent refractive error in the right eye was -2.09 +/- 0.89 D, the mean central curvature of the right cornea by videokeratography was 44.5 +/- 1.3 D, and the mean axial length of the right eye was 24.13 +/- 0.71 mm. CONCLUSIONS: Four of five children aged 8- to 11-years-old were able to adapt to rigid gas-permeable contact lens wear. The CLAMP Study aims to further clarify the effect of rigid gas-permeable contact lenses on myopia progression in children.