RESUMO
The therapeutic role of dehydroepiandrosterone (DHEA) supplementation among infertile women with diminished ovarian reserve (DOR) is still unclear. Objective evaluation of different ovarian reserve tests (ORTs) such as serum anti-Mullerian hormone (AMH), serum follicle stimulating hormone (FSH), and antral follicle count (AFC) in women with diminished ovarian reserve is required. This is a cross-sectional study performed in Mosul city, Iraq, with 122 infertile women who had been diagnosed with DOR. The enrolled women's age ranged from 18 to 45 years old (mean age of 29.46 ± 2.64 years). The ages of the enrolled women ranged from 18 to 45 years (mean age of 29.46 ± 2.64 years). To assess the influence of DHEA supplements (25 mg, three times/day for 12 weeks) across different age groups, the women were initially divided into three groups (18 to 27 years old, 28 to 37 years old, and ≥ 38 years old). Significant differences were noticed in AMH, FSH, level and AFC before and after DHEA supplementation. (AMH: 0.64 ± 0.82 vs. 1.98 ± 1.32, AFC: 2.86 ± 0.64 vs. 5.82 ± 2.42, and FSH: 12.44 ± 3.85 vs. 8.12 ± 4.64), statistically obvious significant differences regarding the results of AMH (p < 0.001), AFC (p < 0.001), and FSH (p < 0.001). DHEA supplementations improved the ovarian reserve of the enrolled women, which was more evident in younger women (<38 years old) than older women (≥38 years old). The AMH serum levels and AFC value can be considered the best, most reliable and significant OR parameters. However, large randomized multicenter studies are required to confirm the available results and data.
Assuntos
Desidroepiandrosterona , Reserva Ovariana , Humanos , Feminino , Desidroepiandrosterona/sangue , Desidroepiandrosterona/administração & dosagem , Desidroepiandrosterona/uso terapêutico , Desidroepiandrosterona/farmacologia , Adulto , Reserva Ovariana/efeitos dos fármacos , Pessoa de Meia-Idade , Adulto Jovem , Adolescente , Suplementos Nutricionais , Estudos Transversais , Simulação por Computador , Hormônio Antimülleriano/sangue , Hormônio Foliculoestimulante/sangue , Infertilidade Feminina/tratamento farmacológico , Infertilidade Feminina/sangueRESUMO
In the present study, TiFe2O4@SiO2-SO3H heterogeneous catalyst was successfully synthesized and applied to generate biodiesel from oleic acid, and palmitic acid using an esterification process. In this sense, the nanocatalyst surface was characterized using TEM, TGA, XRD, FTIR, VSM, BET, SEM, and EDX analyses. Nanocatalyst TiFe2O4@SiO2-SO3H showed high activity for the esterification of oleic acid and palmitic acid. Also, the nanocatalyst can be easily recovered with a bar magnet and reused many times without any loss of activity.