Real-Time and Online Monitoring of Hazardous Volatile Organic Compounds in Environmental Water by an Unmanned Shipborne Mass Spectrometer System.

Hazardous volatile organic compounds (VOCs) are one of the critical concerns in environmental water due to their toxicity to aquatic organisms and drinking water. Therefore, rapid detection of hazardous VOCs in environmental water is highly needed as many analytical methods are limited to on-site monitoring. In this work, we designed a novel unmanned shipborne mass spectrometer (US-MS) system for the real-time and online monitoring of hazardous VOCs in environmental water. The US-MS system consists of a miniaturized mass spectrometer, an automatic sampling device, a robust unmanned ship, and other monitoring and control devices. Along with the navigation route of the US-MS system, environmental water was continuously introduced into the MS system for the online and real-time detection of hazardous VOCs via a liquid/gas exchange membrane. Analytical performances of the US-MS system were investigated by a mixture of 10 VOCs showing low limits of detection (LODs: 0.31-1.26 ng/mL), good reproducibility (RSDs: 2.93-11.03%, n = 7), and excellent quantitative ability (R2 > 0.99). Furthermore, on-site detection and online monitoring of hazardous volatile contaminants such as benzene, chloroprene, and toluene in different aquatic environments such as rivers and lakes were successfully demonstrated, showing excellent field applicability of the US-MS system. Overall, the newly developed US-MS system could perform on-site, online, and real-time monitoring of complex VOCs in environmental water, showing good performances and versatile applications in water analysis.

Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia.

FLT3-ITD mutant has been extensively studied as a drug discovery target for acute myeloid leukemia. Based on our previous discovered FLT3 inhibitor (2), a series of urea group based indolone derivatives were designed, synthesized, and biological evaluated as novel FLT3 inhibitors for the treatment of FLT3-ITD positive AML. Among them, compound LC-3 exhibited potent inhibitory effects against FLT3 (IC50 = 8.4 nM) and significantly inhibited the proliferation of FLT3-ITD positive AML cells MV-4-11 (IC50 = 5.3 nM). In the cellular context, LC-3 strongly inhibited FLT3-mediated signaling pathways and induced cellular apoptosis by arresting cell cycle in G1 phase. In the in vivo studies, LC-3 significantly suppressed the tumor growth on MV-4-11 xenograft models (10 mg/kg/day, TGI = 92.16%) without exhibiting obvious toxicity. These results suggested that compound LC-3 might be a potential drug candidate for FLT3-ITD positive AML.

Occlusal contact characteristics of molar teeth with food impaction: Insights from a new digital technique.

OBJECTIVES: The objective of this study was to analyze the occlusal contact characteristics of the food-impacted teeth using a new digital technique. METHODS: A 3D occlusal analysis method was developed for studying the occlusal contact characteristics of teeth affected by food impaction. In this self-controlled study, food-impacted molars from 20 participants constituted the experimental group. The corresponding healthy teeth on the opposite side served as the control group. Variables such as occlusal force (OF), occlusal contact area (OCA), and the number and distribution of occlusal contact points (OCN) in the mesio-distal directions were measured and compared between the two groups. RESULTS: There was no statistical significant difference in the values of OF, OCA and OCN between the food-impacted molars and the healthy control molars (P > 0.05). However, paired T-tests indicated significant difference in the proportion of mesial OF, OCA, and OCN in the second molars of the experimental group (0.22, 0.28 and 0.28, respectively) and the control group (0.66, 0.63, and 0.63 respectively) (P < 0.001). CONCLUSIONS: The abnormal distribution of occlusal contacts in the second molar, primarily characterized by excessive occlusal contact in the distal direction may contribute to the occurrence of food impaction. CLINICAL SIGNIFICANCE: The present study identified variations in the distribution of occlusal contacts and occlusal component force in food-impacted teeth. These findings can assist dentists in making more targeted occlusal adjustments, or applying other treatment modalities, to effectively address food impaction.