1.
J Org Chem
; 86(14): 9299-9305, 2021 Jul 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34181422
RESUMO
Brønsted acid-catalyzed direct C(sp2)-H alkylation of N-heteroaromatics with cyclic ethers via a cross-dehydrogenative coupling reaction in the presence of benzoyl peroxide was developed. This methodology successfully provided an easy access to a variety of alkyl-substituted quinoxaline, benzoimidazole, pyrazine, pyrimidine, quinoline, isoquinoline, and pyridine derivatives in up to 94% yield under metal-free conditions.