Myrothins A-F from Endophytic Fungus Myrothecium sp. BS-31 Harbored in Panax notoginseng.

Endophytic fungi play important roles for host's stress tolerance including invasion by pathogenic microbes. Small molecules are common weapons in the microbe-microbe interactions. Panax notoginseng is a widely used traditional Chinese medicinal plant and harbors many endophytes, some exert functions against pathogens. Here, we report six new compounds named myrothins A-F (1-6) produced by Myrothecium sp. BS-31, an endophyte isolated from P. notoginseng, and their antifungal activities against pathogenic fungi causing host root-rot disease. Their structures were elucidated with analysis of spectroscopic data including 1D and 2D NMR, HR-ESI-MS. Myrothins B (2) and E (5) showed the weak activity against Fusarium oxysporum and Phoma herbarum, and myrothins F (6) showed weak activity against F. oxysporum.

Role stress, occupational burnout and depression among emergency nurses: A cross-sectional study.

BACKGROUND: Emergency nurses are a professional group at a high risk of burnout and depression. This may influence their mental state and physical health. AIMS: The aim of the study was to explore the relationship between role stress, occupational burnout and depression among emergency nurses. METHODS: A cross-sectional study was carried out among 295 emergency nurses from eight tertiary hospitals in western China. The Role Stress Scale, the Maslach Burnout Inventory-Human Services Survey and the Center for Epidemiologic Studies Depression Scale were employed. Descriptive statistics, independent sample t-tests, one-way analysis of variance, Pearson's correlation analysis and regression analysis were performed. RESULTS: Of the study participants, 54.6% were found to have depressive symptoms and 48.1% had severe occupational burnout. Positive correlations were observed between the scores of role stress and burnout and depression. Approximately 37.1% of the variation in depression was explained by the components of occupational burnout. CONCLUSIONS: Emergency nurses experience high levels of role stress, occupational burnout and depression. Preventive approaches to role stress, burnout and depression are needed to improve their psychological condition and quality of work life.

Perceived stress, coping style and burnout of Chinese nursing students in late-stage clinical practice: A cross-sectional study.

AIM: The aim of this study was to examine the levels of stress, coping style and burnout among Chinese nursing students in late-stage clinical practice and to identify their relationships. BACKGROUND: High stress, passive coping and burnout among nursing students in late-stage clinical practice may contribute to severe psychological consequences. DESIGN: A descriptive and cross-sectional study was conducted in November and December 2020. METHODS: Participants completed the Perceived Stress Scale, Simplified Coping Style Questionnaire and Maslach Burnout Inventory-Human Service Survey to examine their stress levels, coping style and burnout. Intention to leave the profession was also assessed. RESULTS: Approximately 36.1 % of nursing students experienced emotional exhaustion and 85.3 % of nursing students perceived themselves to have moderate to high stress levels. A positive coping style can protect nursing students from depersonalization and reduced personal accomplishment. High stress and passive coping style predicted emotional exhaustion. Passive coping style and high stress were significant factors leading to intention to quit nursing education before graduation. CONCLUSIONS: Lowering the level of stress and using positive coping behaviors may help students during late internship to mitigate burnout and avoid leaving nursing education. Therefore, nurse educators and clinical nursing mentors need to consider developing strategies and interventions to reduce the decline in nursing students entering nursing education and prevent burnout.

Mobile phone addiction and its association with burnout in Chinese novice nurses: A cross-sectional survey.

AIM: To explore the levels of mobile phone addiction and burnout and their relationships among novice nurses. DESIGN: A cross-sectional investigation design. METHODS: Questionnaires were distributed to 400 novice nurses in five public hospitals in China. A total of 366 participants completed the survey. Data collected in 2020 were analysed by using descriptive statistics, an independent t test and Pearson's correlation analysis. RESULTS: The results showed that the frequency of nursing adverse events was associated with higher level of mobile phone addiction in novice nurses, and 52.46% of the participants (N = 366) presented a high level of occupational burnout. Moreover, the results indicated that there was a positive correlation between the novice nurses' mobile phone addiction level and burnout (r = .33, p < .01). CONCLUSION: The level of mobile phone addiction may affect nursing adverse events and nurses' burnout. Education on novice nurses' mobile phone use seems necessary to ensure patient safety and burnout prevention. IMPACT: Findings of this study expanded important knowledge about mobile phone addiction and its potential influence on nursing safety and nurse burnout and may place significant implications to staff nurse management and in-service education.

The influence of mobile phone addiction and work procrastination on burnout among newly graduated Chinese nurses.

PURPOSE: The study was conducted to explore the relationship between mobile phone addiction, work procrastination, and burnout among newly graduated nurses. DESIGN AND METHODS: A cross-sectional survey involving 220 newly graduated nurses in China was conducted from June to July 2020. FINDINGS: Approximately 60.9% of newly graduated nurses experienced occupational burnout; 72.7% of newly graduated nurses were characterized by moderate or greater procrastination and mobile phone addiction was at a moderate level. Mobile phone addiction and work procrastination were significant factors leading to emotional exhaustion and cynicism. Work procrastination was also an independent predictor of reduced professional efficacy. PRACTICE IMPLICATIONS: Reducing the level of mobile phone addiction and work procrastination among newly graduated nurses might be effective for burnout prevention.