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Biochem Biophys Res Commun ; 717: 150041, 2024 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-38710142

RESUMO

Ocular inflammation-associated diseases are leading causes of global visual impairment, with limited treatment options. Adiponectin, a hormone primarily secreted by adipose tissue, binds to its receptors, which are widely distributed throughout the body, exerting powerful physiological regulatory effects. The protective role of adiponectin in various inflammatory diseases has gained increasing attention in recent years. Previous studies have confirmed the presence of adiponectin and its receptors in the eyes. Furthermore, adiponectin and its analogs have shown potential as novel drugs for the treatment of inflammatory eye diseases. This article summarizes the evidence for the interplay between adiponectin and inflammatory eye diseases and provides new perspectives on the diagnostic and therapeutic possibilities of adiponectin.


Assuntos
Adiponectina , Inflamação , Receptores de Adiponectina , Transdução de Sinais , Humanos , Adiponectina/metabolismo , Receptores de Adiponectina/metabolismo , Animais , Inflamação/metabolismo , Oftalmopatias/metabolismo , Oftalmopatias/tratamento farmacológico
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