Medium-long-term outcomes of saphenous vein graft in Peyronie surgery: Is there a need for new graft material?

AIM: We present our results of tunical incision and saphenous graft surgery for men with short penis and who cannot have sexual relations due to curvature linked to chronic Peyronie plaques. INTRODUCTION: Peyronie disease is a chronic process where fibrotic plaques form in the tunica albuginea. The plaques cause pain in the acute period and cause the penis to bend after inflammation ends. Surgical procedures are required for curvature>30°. Saphenous vein graft (SVG) replacement is an alternative method for tunical plaque incision defect. MATERIAL-METHOD: The outcomes for 71 patients with TI+SVG surgery were retrospectively assessed. Plaque features (curvature angle, location, direction of curve and tunical defect diameter), operative and postoperative properties (surgery duration, recurrent curvature, penis shortening, glans hypoesthesia, satisfaction score, follow-up duration), preoperative-postoperative penis length and IIEF-5 score differences were assessed. RESULTS: Mean age was 61.12±7.9 (45-75) years, mean curvature angle was 62.0±14.7 (50-90), location was mid-penile for 46 (65%), with angulation direction toward the dorsal for 37 (52%), and the defect area after tunical incision was 15.5±3.9 (10-23) cm2. With mean follow-up duration of 37±9.4 months, 9 patients had re-curvature (13.2%), 8 had short penis (11.3%) and 7 had ED identified (9.4%). Total penis straightening was present for 86.8%, with patient satisfaction score of 21.1±4.4 (8-25). CONCLUSION: The TI+SVG method is an effective method for Peyronie surgery in the medium-long term.

Corporoplasty under local anesthesia: Cost-effective improvement of the surgical treatment of Peyronie's disease.

INTRODUCTION AND OBJECTIVES: Peyronie's disease produces penile curvature that leads, in certain cases, to difficulties in having satisfactory sexual relations. The objective of this study is to evaluate the functional and cost-effectiveness results obtained in the surgical treatment of penile curvature due to Peyronie's disease under local anesthesia, comparing them with those performed under a general-spinal anesthesia regimen. MATERIAL AND METHODS: Two groups of patients undergoing corporoplasty are compared according to the type of anesthesia used. Group 1 consists of 32 patients who underwent major outpatient surgery and under local anesthesia from June 2016 to June 2019. Their data are collected prospectively. Group 2 consists of 30 patients who underwent surgery under general/spinal anesthesia with hospital admission, from January 2013 to December 2015, with their data collected retrospectively. Anesthetic and surgical procedure, postoperative functional results, degree of satisfaction and hospital costs between both groups are analyzed, considering p≤0.05 as statistical significance and analyzing the results with the SPSS 20.0 program. RESULTS: Of the 32 patients included in group 1, none required admission for intra or postoperative complications. In both groups, an improvement of the PDQ-test was observed without statistically significant differences, with the degree of global satisfaction above 95% in both groups. There were also no differences in the appearance of complications secondary to the anesthetic procedure or the hospital regime. We observed differences in hospital costs, being 44% lower for the group performed with local anesthesia. CONCLUSIONS: Surgical treatment of penile curvature under local anesthesia improves the cost-effectiveness ratio with the same quality of care, degree of satisfaction and postoperative functional results, maintaining a similar rate of intra/postoperative complications. For this reason, we consider that corporoplasty can be successfully performed under local anesthesia.

Efficacy and safety of collagenase Clostridium histolyticum in Peyronie's disease following a modified treatment protocol. / Eficacia y seguridad de la colagenasa de Clostridium histolyticum en la enfermedad de Peyronie según un protocolo de tratamiento modificado.

INTRODUCTION: Collagenase Clostridium histolyticum (CCH) is the only approved treatment for conservative management of Peyronie's disease (PD) that has demonstrated efficacy and safety in clinical trials. However, as the standard treatment protocol is time and resource consuming, we are introducing a new CCH treatment protocol with a more cost-effective profile. Our goal is to evaluate its efficacy and safety. MATERIALS AND METHODS: We included patients with PD in stable phase, with curvatures of 30-90degrees. Ventral curvatures and complex deformities were excluded. The treatment protocol consists of a full dose of CCH injected along the PD plaque, forming two lines of four injections. Patients were educated in daily penile modeling activities. The need for a new treatment cycle, up to a maximum of 8 cycles or until the 30-degree curve was decreased, was reevaluated every 4weeks. Changes in curvature and number of cycles were recorded to evaluate the efficacy. Regarding safety evaluation, treatment-related adverse events (TRAEs) were recorded, including rupture of the corpora cavernosa, penile hematoma, hematuria, and local infection. RESULTS: Thirty-one patients were treated under the modified protocol. The mean initial curvature was of 49.84 (±15.83) degrees. Curvature improvement was recorded in 25 patients (80.6%), with a mean absolute reduction of 20.65 (±15.42) degrees and relative reduction of 44%. The mean curvature after treatment was 30.67 (±17.25) degrees. Most patients required one (19.4%) or two (54.8%) injections. No patient presented TRAEs. CONCLUSIONS: The results suggest that the modified CCH treatment protocol is effective and safe, but more studies should be carried out to optimize the current standard protocol.

Complex Peyronie's disease cases: surgery with or without penile prosthesis placement. / Casos complejos. Enfermedad de Peyronie: cirugía sin/con implante de prótesis de pene.

INTRODUCTION AND OBJECTIVE: Surgery is the treatment of choice for patients with Peyronie's disease presenting difficulty in penetration or erectile dysfunction without adequate response to therapy. Several techniques have been described, and urologists must be aware of their possible complications and sequelae in order to offer the patient the best possible alternative. PATIENTS AND METHODS: Three complex cases of patients with Peyronie's disease are presented. The first case exposes a complication after penile plication for the treatment of a major dorsal curve. The second case refers to difficult anal penetration secondary to a problem of erection direction after plaque incision surgery with oral mucosa grafting. The last case is a patient with a late post-operative complication of a three-piece prosthesis placement with plaque incision and equine collagen patch. RESULTS: Surgical options for each case are detailed and discussed. After patients were informed, the decision was taken in a consensual manner. CONCLUSIONS: Surgery for Peyronie's disease requires the urologist's consideration of the functional, aesthetic and psychological spheres. A systematic approach to all of these avoids complications, sequels and improves results.

Enlargement of length and girth associated with implantation of penile prostheses. / Implante de prótesis con reconstrucción y agrandamiento de pene en el mismo acto quirúrgico.

INTRODUCTION: Reduction in penile size is due to numerous conditions including Peyronie's disease, previous penile surgeries, diabetes, trauma, erectile dysfunction, pelvic surgery, and aging. Elasticity of the tunica albuginea is adversely affected by any of the above. Fibrosis then triggers progressive erectile dysfunction OBJECTIVES: When a penile prosthesis is indicated, it is important to determine whether the penis has already diminished in size prior to insertion of the implant. Because a prosthesis only provides axial rigidity and is not associated with the enlargement of the penis, reflection of strategies to simultaneously enlarge the size of the penis while implanting a device is recommended. MATERIAL AND METHODS: A systematic review of current scientific literature regarding procedures and tactics currently available for penile implants and enlargement was conducted. RESULTS: The literature demonstrates that the evolution of penile implant surgery, accompanied by consideration of enlargement, has evolved through 5 fundamental techniques: Incision with Grafting; Sliding with Grafting; Modified Sliding without Grafting (MoST); Multiple Slit without Grafting (MUST); and the Egydio Paradigm for Tunica Expansion Procedures (TEP), a further evolution of previous strategies to achieve state of the art penile implantation accompanied by maximum penile enlargement. Evolving technology of tunica expansion procedures has led to diminution of the size of tunica defects and avoidance of grafts to prevent bulging and indentation, while developing solutions to preserve the strength of the tunica albuginea for firm positioning of the cylinders in the interior of the corpora cavernosa. CONCLUSIONS: The evolution of these techniques is the transformation of larger tunica defects into smaller ones. While grafts are often used to reinforce the penile structure due to large defects, multiple incisions of the tunica albuginea are gaining popularity to promote girth and length enlargement without grafts and without the loss of tunica strength necessary to support the cylinders inside the corpora.

Dermal graft surgery for Peyronie's disease: Long term results at a 15 years follow-up.

OBJECTIVES: To evaluate long-term outcomes of patients subjected to corporoplasty, plaque incision and excision, and autologous dermal grafting, with at least 15 years of follow-up. METHODS: The charts of consecutive patients with a penile curvature and a minimum of 15 years follow up were retrospectively reviewed. The patients underwent corporoplasty and penile straightening with autologous dermal grafting, harvested at the level of the anterior-superior iliac spine. At the time of the follow-up, a postoperative IIEF - 5 questionnaire was administered by telephonic interview, and patients were also asked to complete an 8 items self-evaluation questionnaire. After signing informed consent, the patients were invited to undergo dynamic and basal penile sonography, as well as injection of 10 mcg of PGE1 for dynamic evaluation of the graft. RESULTS: A total of 16 patients were identified. Penile shortening of up to 1.5 cm was reported in about 40% of cases and residual bending was reported by 4 of 16 patients. However, there was no impairment in penetration. On physical examination of the suture site, a small indurated nodule was palpable in two patients. Data regarding the dynamic sonography is available for the 5 patients who accepted to undergo the test. No sign of a fibrotic reaction or calcification was detected in the static phase. After injection of 10 mcg PGE-1, in comparison to the basal measurement, the dermal grafts showed compliant length adaptation. CONCLUSIONS: Dermal graft substitution surgery for Peyronie's disease allows to obtain good functional results with durable satisfaction of the patients on long term follow up.

OBJETIVOS: Evaluar los resultados a largo plazo de los pacientes sometidos a corporoplastia, incisión y escisión de la placa, e injerto dérmico autólogo, con al menos 15 años de seguimiento. MÉTODOS: Revisamos retrospectivamente las historias clínicas de los pacientes con incurvación peneana y un mínimo de 15 años de seguimiento. Los pacientes fueron sometidos consecutivamente a corporoplastia y corrección de la curvatura con injerto dérmico autólogo, obtenido a nivel de la espina iliaca antero-superior. En el seguimiento, se pasó el cuestionario IIEF-5 postoperatorio mediante entrevista telefónica, y también se pidió a los pacientes completar un cuestionario de autoevaluación de 8 preguntas. Después de firmar un consentimiento informado, los pacientes fueron invitados a realizar ecografía peneana dinámica y basal, así como inyección de 10 mcg de PGE1, para la evaluación dinámica del injerto. RESULTADOS: Fueron identificados un total de 16 pacientes. Cerca del 40% de los casos comunicaban un acortamiento del pene de hasta 1,5 cm y 4 de 16 pacientes referían incurvación residual. Sin embargo, no había empeoramiento de la penetración. En la exploración física del sitio de la sutura, en dos pacientes era palpable un pequeño nódulo indurado. Los datos referentes a la ecografía estaban disponibles en los 5 pacientes que aceptaron realizar la prueba. En la fase estática no se detectaron signos de reacción fibrótica o calcificación. Después de la Inyeccion de 10 mcg de PGE-1, los injertos dérmicos mostraron una adaptación longitudinal adecuada en comparación con la medición basal. CONCLUSIONES: En la enfermedad de La Peyronie, la cirugía de substitución con injerto dérmico permite obtener buenos resultados funcionales con satisfacción de los pacientes perdurable en el seguimiento a largo plazo.

Ten-year experience with multimodal treatment for acute phase Peyronie's disease: A real life clinical report. / Diez años de experiencia con el tratamiento multimodal de la fase aguda de la enfermedad de Peyronie: reporte médico de la vida real.

OBJECTIVES: To present our experience with multimodal therapy for Peyronie's disease. METHODS: Retrospective data were collected since 2008 to 2017. The following features were evaluated at baseline and after treatment: age, duration of disease, erectile function, erected penile curvature, and stretched penile length. All patients were offered the same protocol including: 12 intralesional verapamil injections, oral therapy (OT) ?L-arginine 2g once and pentoxifylline 400mg 3 times a day for 6 months?, and penile traction therapy. The adherence to each of the 3 components of multimodal treatment was evaluated. RESULTS: One hundred and seventy-seven individuals were considered. Depending on the grade of adherence our survey was divided into 3 groups. Group 1: patients who only completed OT; group 2: men who accomplished OT and intralesional verapamil injections; group 3: patients who completed the entire protocol. Seventy-six, 45 and 56 men were assigned to group 1, 2 and 3 respectively. The mean age at the diagnosis was 59±8.4, 59.1±5.9 and 54.2±4.8 years, while the mean duration of the disease was 6.3±3.4, 4.8±2.9 and 3.9±3.1 months in group 1, 2 and 3. The erected penile curvature before and after treatment was 24.2±9 and 23.7±8.9° in group 1 (P<.36); 25.4±16.8 and 24.1±13.6° in group 2 (P<.34), and 34.3±17.9 and 26.1±17.2° in group 3 (P<.001). CONCLUSIONS: OT alone was successful to block the progression of the disease. The add of intralesional verapamil injections to OT brought only mild improvements. The complete protocol significantly reduced erected penile curvature and improved erectile function.

Actualización sobre la enfermedad de Peyronie / Update on Peyronie´s disease

La enfermedad de Peyronie es un trastorno de la túnica albugínea del pene caracterizada por la formación de placas fibrosas que conlleva a curvaturas patológicas del mismo. El presente artículo tiene como objetivo revisar los nuevos conceptos y los avances en los tratamientos, tanto quirúrgicos como no quirúrgicos, los orales o intralesionales, para manejar adecuadamente al paciente o para seguir un tratamiento que conlleve la mejoría de la sintomatología y de la calidad de vida de los hombres que padecen esta enfermedad. La enfermedad de Peyronie es un trastorno que no es tan infrecuente en la población masculina, que se acompaña de disfunción eréctil, una de las alteraciones que genera más consultas urológicas.

Peyronie’s disease, it is a disorder of the tunica albuginea of the penis, characterized by the formation of fibrotic plates that cause pathological curvatures of this organ. The present article aims to update new concepts, and advances in the both surgical and non surgical oral or intralesional treatments, in order to manage adequately the patient, or to follow a treatment that would improve their symptomatology and the quality of life. Peyronie’s disease is a disorder, not so infrequent in the masculine population which accompanies erectile dysfunction, one of the disorders that seen in urological services.