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1.
Vestn Oftalmol ; 139(1): 75-79, 2023.
Artigo em Russo | MEDLINE | ID: mdl-36924517

RESUMO

Intrastromal corneal ring segments (ICRS) of in various shapes are used to correct structural changes in the cornea and improve visual acuity in keratoconus (KC). The most serious complications of the technology infection, vascular ingrowth, and extrusion. In this study a 44-year-old patient underwent deep anterior lamellar keratoplasty (DALK) 5 years after implantation of ICRS in the shape of an incomplete ring to treat its extrusion of up to 30%, vascular ingrowth into the cornea and corneal syndrome. The following DALK technique was used: excision of the free part of the corneal segment, removal of the remaining part of the corneal segment, excision of 80% of thickness of the corneal block with a 8.5-mm trepan, pneumatic dissection of the stroma down to the Descemet membrane (DM), removal of the remaining stroma on the viscoelastic pillow, laying and suture fixation of the donor graft. There were no complications during the postoperative period, the graft remained transparent for up to 10 months. Uncorrected visual acuity (UCVA) increased from 0.01 to 0.4, best corrected visual acuity (BCVA) increased from 0.3 to 0.7. The number of endothelial cells decreased from 2980 to 2670 cells/mm2 (10.4%). This clinical case demonstrates that DALK surgery can be a reliable method of patient rehabilitation in cases of extrusion of ICRS in the shape of an incomplete ring and vascular ingrowth.


Assuntos
Transplante de Córnea , Ceratocone , Humanos , Transplante de Córnea/efeitos adversos , Transplante de Córnea/métodos , Células Endoteliais , Córnea/cirurgia , Acuidade Visual , Ceratoplastia Penetrante/métodos , Ceratocone/diagnóstico , Ceratocone/cirurgia , Topografia da Córnea , Estudos Retrospectivos
2.
Graefes Arch Clin Exp Ophthalmol ; 258(7): 1459-1468, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32296993

RESUMO

PURPOSE: To evaluate vision-related quality of life in keratoconus patients and associated impact of keratoconus severity indicators using the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). METHODS: This was a prospective cross-sectional study carried out from November 1, 2014, to April 30, 2015, in the corneal service of the Hôtel-Dieu hospital, Paris, France. A hundred and one keratoconus patients were consecutively enrolled. Participants completed a French-validated version of the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). Manifest refraction, maximum keratometry value, and corneal thinnest point were recorded. Associations between clinical and demographic factors, previous medical or surgical treatment, and NEI-VFQ-25 scale scores were evaluated. RESULTS: Vision-related quality of life was no better in patients managed with rigid gas permeable contact lens, collagen cross-linking, or intracorneal ring segment implantation, compared with untreated patients. In advanced keratoconus (stages II, III, and IV of Amsler-Krumeich classification), rigid gas permeable contact lens wearers had better general vision but more ocular pain. Distance-corrected visual acuity worse than 20/40, mean refractive cylinder > 2.5 diopters, and corneal thinnest point < 460 µm in the better eye were associated with a lower vision-related quality of life. In multivariate analysis, only the uncorrected and distance-corrected visual acuity of the better eye remained significantly correlated with vision-related quality of life. CONCLUSIONS: Low distance-corrected visual acuity in the better eye was the strongest predictor of low vision-related quality of life.


Assuntos
Córnea/cirurgia , Ceratocone/psicologia , Qualidade de Vida , Acuidade Visual , Adolescente , Adulto , Córnea/patologia , Topografia da Córnea/métodos , Estudos Transversais , Feminino , Seguimentos , Humanos , Ceratocone/diagnóstico , Ceratocone/cirurgia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Índice de Gravidade de Doença , Inquéritos e Questionários , Adulto Jovem
3.
Ophthalmic Res ; 63(2): 203-212, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31694028

RESUMO

PURPOSE: To compare the clinical and histological outcomes after intrastromal corneal ring segment (ICRS) implantation with and without plasma rich in growth factors (PRGF) in an experimental animal model. MATERIALS AND METHODS: First, the toxicity of PRGF was tested in hen's keratocyte cultures. Then, an animal model with 18 hens was randomly divided into 2 groups. In the first group, one ICRS was implanted in each eye (ICRS group). In the second group, the ICRS was firstly immersed 30 min in PRGF-Endoret solution, then implanted and, finally, PRGF-Endoret was inoculated into the channel (PRGF-ICRS group). Animals of each group were also separated into 3 groups regarding the time they were sacrificed, and corneal tissue was fixed for histological analysis at 2, 7 and 30 days. Cell death was detected by terminal uridine nick end labelling (TUNEL) assay. Proliferation was labelled by 5-bromo-2-deoxyuridine (BrdU) incorporation and myofibroblast differentiation by alpha-smooth muscle actin (αSMA) immunodetection. Clinical examination, analyzing epithelial wound closure, deposits and stromal haze, was carried out at the different study times. RESULTS: No toxic effect was observed by PRGF in hen stromal cell cultures. Clinically, in PRGF-ICRS corneas at 7 days, there were more deposits with higher intensity than in ICRS group. Histologically, at day 2 there was less epithelial damage over the segment in the PRGF-ICRS group, corneal oedema around the segment disappeared earlier and, at day 7, there was also double the number of cells around the segment than in the ICRS group displaying different morphologies. The number of TUNEL-positive cells was statistically higher in the PRGF-ICRS group at 7 and 30 days, and the number of BrdU-positive cells was statistically higher at all analyzed times. However, there were no differences in the number of αSMA-positive cells at 30 days between both groups. CONCLUSIONS: The ICRS immersion in PRGF-Endoret prior and after to its corneal implantation, in an experimental animal model, enhances clinical deposits and histological cell turnover without increasing myofibroblast differentiation reducing stromal wound-healing time after surgery.


Assuntos
Ceratócitos da Córnea/patologia , Substância Própria/patologia , Peptídeos e Proteínas de Sinalização Intercelular/farmacologia , Procedimentos Cirúrgicos Oftalmológicos , Plasma , Cicatrização , Animais , Diferenciação Celular , Proliferação de Células , Células Cultivadas , Galinhas , Substância Própria/cirurgia , Humanos , Masculino
4.
Int Ophthalmol ; 40(11): 2835-2844, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32535750

RESUMO

PURPOSE: To evaluate one-year visual, refractive, and topographic outcomes of 58 eyes of 53 keratoconus patients who underwent surgery with a progressive thickness intrastromal corneal ring segment (ICRS). METHODS: This multi-center, retrospective, observational study evaluates the one-year effects of progressive thickness ICRS implanted in keratoconus patients meeting the inclusion criteria. One or two progressive ICRS were implanted in the selected eyes after creating an intrastromal tunnel with a femtosecond laser. Pre- and postoperative uncorrected distance visual acuity, best-corrected distance visual acuity, manifest refraction (both spherical equivalent and cylindrical refractions), corneal astigmatism, maximum keratometry, corneal thickness, and corneal topography measurements and indices were evaluated. RESULTS: In this retrospective case series, 58 eyes of 53 keratoconus patients were included with a follow-up of 12 months. The mean age was 30.89 ± 11.90 years. There were improvements postoperatively in mean values of visual acuities, both uncorrected from 0.71 (preoperatively) to 0.28 (log MAR), and best-corrected from 0.28 to 0.10 (log MAR), mean cylindrical refraction from - 2.35 ± 1.51 to - 4.15 ± 2.23 D, and mean spherical equivalent from - 2.10 ± 2.25 to - 4.64 ± 3.2 D. There was also a reduction in maximal keratometry from 54.21 D preoperatively to 50.93 D postoperatively. CONCLUSION: The implantation of the progressive thickness ICRS is an effective and safe method to improve the vision of keratoconic eyes. Corneal stability was maintained at the 12-month mark.


Assuntos
Substância Própria , Ceratocone , Adolescente , Adulto , Substância Própria/cirurgia , Topografia da Córnea , Humanos , Ceratocone/diagnóstico , Ceratocone/cirurgia , Próteses e Implantes , Implantação de Prótese , Refração Ocular , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
5.
Int Ophthalmol ; 40(11): 2847-2854, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32562024

RESUMO

BACKGROUND/AIMS: Intrastromal corneal ring segments (ICRS) have been found to be useful in correcting keratoconus by decreasing irregular astigmatism, thereby potentially improving visual acuity. However, its long-term effects in keratoconus progression are not completely understood, mainly concerning the effects of age on ICRS implantation results. This study aimed to evaluate long-term effects of ICRS implantation according to age at implantation. METHODS: We conducted a longitudinal retrospective study, where we evaluated patients with keratoconus who underwent ICRS implantation between 2004 and 2012. RESULTS: We evaluated 34 eyes for 5 years post-operatively. The mean age of the 21 men and 7 women was 20.59 ± 4.65 years. Best spectacle-corrected visual acuity (BSCVA) improved from 0.32 ± 0.19 in the preoperative period to 0.46 ± 0.27 6 months post-operatively. After up to 5 years of follow-up, there was no significant difference in mean visual acuity of the group. As expected, there was a significant decrease in keratometric values after corneal ring implantation, which remained stable over the 5-year follow-up. Among the 34 cases analysed, nine (26%) showed signs of disease progression. In eight of the nine documented progression cases, patients were 21 years old or younger, revealing that these patients were sevenfold more likely to progress than those aged over 21 years. CONCLUSION: In our series of cases, ICRS implantation was shown to be an excellent treatment to reduce corneal curvature and improve visual acuity at all ages, but it did not stabilize the disease, especially in young patients with more aggressive forms of the keratoconus.


Assuntos
Ceratocone , Adolescente , Adulto , Idoso , Pré-Escolar , Estudos de Coortes , Substância Própria/cirurgia , Topografia da Córnea , Feminino , Seguimentos , Humanos , Ceratocone/diagnóstico , Ceratocone/cirurgia , Masculino , Próteses e Implantes , Implantação de Prótese , Refração Ocular , Estudos Retrospectivos , Adulto Jovem
6.
Int Ophthalmol ; 39(3): 651-659, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29429144

RESUMO

PURPOSE: To evaluate the topographic, refractive, and pachymetric changes after ethanol-assisted transepithelial corneal cross-linking (CXL) to stabilize progression of keratoconus (KC). PATIENTS AND METHODS: This study retrospectively evaluated the long-term topographic, refractive, and pachymetric changes in patients diagnosed with KC who underwent corneal cross-linking and/or intrastromal corneal ring segment (ICRS) implantation. The subjects were divided into three groups, corresponding to eyes treated with CXL alone (group 1), CXL and ICRS at the same time (group 2), and CXL after ICRS implantation (group 3). Corrected visual acuity and refraction, steep keratometry (SteepK) values, steepest keratometry reading on sagittal curvature map, and corneal thickness were recorded preoperatively and at each visit. Changes between measurements were assessed during follow-up. RESULTS: Corrected distant visual acuity (CDVA) values improved in all groups compared with baseline, but the differences were not statistically significant except for the first year (p > 0.05). In groups 1 and 3, SteepK values did not change statistically significantly during the entire follow-up (p > 0.05). In group 2, SteepK values statistically significantly decreased at all follow-up examinations compared with baseline, determined as the first month after ICRS implantation (p < 0.05). Complication rates were acceptable without any need for surgical intervention. CONCLUSIONS: Single-session ethanol-assisted transepithelial CXL with or without ICRS implantation was a safe and effective procedure to halt progression of KC.


Assuntos
Substância Própria/cirurgia , Reagentes de Ligações Cruzadas/intoxicação , Etanol/farmacologia , Ceratocone/terapia , Procedimentos Cirúrgicos Oftalmológicos/métodos , Fotoquimioterapia/métodos , Implantação de Prótese/métodos , Adulto , Colágeno/farmacologia , Topografia da Córnea , Epitélio Corneano/efeitos dos fármacos , Epitélio Corneano/patologia , Feminino , Seguimentos , Humanos , Ceratocone/diagnóstico , Masculino , Fármacos Fotossensibilizantes/farmacologia , Refração Ocular , Estudos Retrospectivos , Fatores de Tempo , Acuidade Visual
7.
Taiwan J Ophthalmol ; 14(1): 78-82, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38654996

RESUMO

PURPOSE: The purpose of this study is to investigate visual and tomographic outcomes and complications of long-arc length intrastromal corneal ring segment (ICRS) implantation for the treatment of advanced keratoconus. MATERIALS AND METHODS: This retrospective study enrolled 10 eyes of 9 subjects. All patients received 320-degree ICRS (320-ICRS) implantation with femtosecond laser-assisted technique based on their advanced grading with preoperative high keratometry (K) value, asphericity (Q), and astigmatism. Medical records and corneal tomography changes of consecutive patients were reviewed at baseline, 1, and 3 months after treatment. RESULTS: There are 6 female and 3 male patients with a mean age of 29.6 ± 7.8 years in this study. Mean K (Km) reduced from 59.01 ± 5.81 D preoperatively to 50.7 ± 5.3 and 50.2 ± 3.66 postoperatively (after 1 month and 3 months respectively, P < 0.001). The changes in mean K, K1, K2, and maximum K (Kmax) reading were all statistically significant (all P < 0.001). Mean uncorrected distance visual acuity (UCVA) improved from 20/400 to 20/200. Mean best-corrected distance visual acuity (BCVA) improved from 20/100 to 20/60. Both UCVA and BCVA showed a trend of improvement at postoperative month 3, though insignificant in BCVA (P = 0.114). Mean Q improved from -1.59 ± 0.62 preoperatively to -0.48 ± 1.08 and -0.11 ± 1.04 postoperatively (after 1 month and 3 months respectively, P = 0.016, 0.002). No intraoperative or postoperative complications were observed. CONCLUSIONS: The present results suggest that implanting a 320-ICRS is a safe and effective procedure for treating patients with advanced keratoconus. Preoperative corneal measurements and the selection of types and thickness of ICRS are important to prevent unpredictable results.

8.
Eur J Ophthalmol ; 34(1): 126-139, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37139606

RESUMO

PURPOSE: to compare five-year outcomes of two complete intracorneal implants (MyoRing versus annular-shaped intracorneal implant [AICI]) combined with accelerated corneal cross-linking (A-CXL) in progressive KCN. METHODS: In this historical cohort study, preoperative and postoperative visual, refractive, tomographic, biomechanical, and aberrometric parameters of 27 eyes of 27 patients who underwent implantation of two complete rings (13 AICI and 14 MyoRing) combined with A-CXL were recorded. RESULTS: The mean age of patients in "AICI plus A-CXL" and "MyoRing plus A-CXL" groups were 28.1 ± 4.6 and 26.3 ± 3.8 years, respectively. All pre- and postoperative visual and refractive parameters between the two groups were not significantly different (p > 0.05). Comparing pre- and postoperative tomographic measurements showed that anterior corneal surface (ACS) flat-K and corneal thickness at pachymetric apex significantly improved for MyoRing plus A-CXL group after five years (p < 0.05). On the other hand, ACS K-max and mean-K values were significantly improved for AICI plus A-CXL group after five years (p < 0.05). Both groups revealed significant improvements in ACS steep-K and corneal astigmatism (p < 0.05). Five years after surgery, the high order aberration in the AICI group (2.60 ± 0.83) was significantly better than the MyoRing group (1.70 ± 0.43) (p = 0.007). CONCLUSIONS: Both complete intrastromal rings (MyoRing or AICI) combined with A-CXL significantly Improved visual, refractive, and corneal aberrometric, biomechanical, and tomographic parameters and halt the progression of KCN with comparable long-term outcomes.


Assuntos
Ceratocone , Fotoquimioterapia , Humanos , Adulto Jovem , Adulto , Acuidade Visual , Crosslinking Corneano , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/uso terapêutico , Substância Própria/cirurgia , Estudos de Coortes , Ceratocone/diagnóstico , Ceratocone/tratamento farmacológico , Ceratocone/cirurgia , Topografia da Córnea/métodos , Seguimentos , Reagentes de Ligações Cruzadas/uso terapêutico , Riboflavina/uso terapêutico
9.
J Optom ; 17(4): 100522, 2024 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-39317099

RESUMO

OBJETIVE: To assess differences in corneal higher-order aberrations (i.e., HOAs) between six different types of irregular corneas (i.e, keratoconus (KC), keratoglobus (KG), pellucid marginal degeneration (PMD), laser-assisted in situ keratomileusis (LASIK), penetrating keratoplasty (PK), and intrastromal corneal ring segments (ICRS)). METHODS: Corneal aberration data from the 3rd and 4th order together with secondary vertical and horizontal coma, and secondary spherical aberration were retrospectively retrieved from a corneal tomographer and compared between irregular cornea types and for 3-, 5-, and 7-mm pupil diameters. RESULTS: Significant differences were observed in vertical coma, oblique trefoil, secondary oblique astigmatism, primary spherical, and secondary spherical between irregular cornea types across all three pupil sizes (all p≤0.025). Vertical coma consistently exhibited the greatest magnitude of HOA across all irregular cornea types and pupil diameters. For the larger pupil diameters (5 and 7 mm), the 3rd order aberrations (mainly coma-like), the 4th order aberrations (mainly spherical-like), and total HOA RMS were significantly lower in the LASIK group compared to all other irregular cornea types (all p≤0.003). Additionally, at pupil sizes of 5 and 7 mm, the 3rd, 4th, coma-like, spherical-like, and total HOA RMS were significantly lower in KC compared to the ICRS and PK groups (all p≤0.01). Furthermore, the 4th, spherical-like, and total HOA RMS were significantly lower in KC compared to KG at pupil diameters of 3 and 7 mm, 5 and 7 mm, and 7 mm, respectively (all p≤0.03). CONCLUSIONS: Vertical coma was the most elevated HOA across all irregular cornea types and pupil diameters. Corneal aberrations were lower in LASIK and KC, and higher in KG and PK.

10.
Curr Eye Res ; 48(4): 365-370, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36524598

RESUMO

PURPOSE: To evaluate the outcomes of implanting a 150° arc-length intrastromal corneal ring segment (ICRS) using a femtosecond laser in patients with post-LASIK ectasia throughout a 5-year follow-up period. METHODS: This study enrolled 45 eyes of 45 patients diagnosed with post-LASIK ectasia who underwent a 150° arc-length Ferrara-type ICRS implantation. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, residual refractive errors, and root mean square (RMS) for coma-like aberration were evaluated preoperatively and at 6-, 12-, 36, and 60 months postoperatively. RESULTS: Mean UDVA (logMAR) ameliorated from 0.53 ± 0.33 preoperatively to 0.26 ± 0.24 at 6 months postoperatively (p < 0.0001). Mean CDVA improved from 0.12 ± 0.13 to 0.04 ± 0.06 (p < 0.0001). Mean UDVA and CDVA remained stable throughout the 5-year follow-up (p > 0.1). No eyes lost lines of CDVA at any follow-up visit compared to preoperatively, and most eyes gained lines. The eyes with a refractive cylinder ≤ 2.00 D varied from 26.7% preoperatively to more than 75% at all postoperative follow-up visits. The maximum keratometry was significantly flattened (p < 0.0001), and the RMS for corneal coma-like aberration was halved (p < 0.0001). 93.3% of the eyes did not show signs of disease progression or regression of the visual or refractive outcomes at any follow-up visits. CONCLUSION: These results suggest that implanting a single 150° arc-length Ferrara-type ICRS is a safe, effective and stable procedure for visual restoration in post-LASIK ectasia. In very few cases, visual and/or refractive instability was experienced throughout the follow-up.


Assuntos
Ceratocone , Ceratomileuse Assistida por Excimer Laser In Situ , Humanos , Seguimentos , Ceratomileuse Assistida por Excimer Laser In Situ/efeitos adversos , Substância Própria/cirurgia , Dilatação Patológica/cirurgia , Coma/cirurgia , Implantação de Prótese , Ceratocone/cirurgia , Refração Ocular , Próteses e Implantes , Topografia da Córnea , Estudos Retrospectivos
11.
J Ophthalmic Vis Res ; 18(4): 369-378, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38250234

RESUMO

Purpose: To evaluate and compare clinical outcomes after femtosecond laser-assisted implantation of 325-degree versus 340-degree arc length intracorneal ring segments (ICRS) in eyes with keratoconus (KCN). Methods: In this prospective non-randomized interventional case series, 23 eyes of 21 patients diagnosed with KCN, underwent femtosecond laser-assisted implantation of two types of ICRS, which included a 325-degree ICRS (Group 325) and a 340-degree ICRS (Group 340). The primary outcome measures were uncorrected distance visual acuity (UDVA), and the secondary outcome measures included corrected distance visual acuity (CDVA), sphere, cylinder, mean refractive spherical equivalent (MRSE), keratometry, vectorial change in corneal astigmatism, and the location of maximum keratometry relative to the corneal apex. The study groups were compared using the primary and secondary outcome measures obtained at postoperative months six and 12. Results: Groups 325 and 340 consisted of 10 and 13 eyes, respectively. The two groups were comparable in terms of parameters measured preoperatively. On comparison to the baseline values, both study groups exhibited a significant increase in UDVA and CDVA measured at postoperative month six (Ps < 0.05) and a significant decrease in the sphere, cylinder, spherical equivalent refraction, and keratometry readings measured at postoperative months six and 12 (Ps < 0.05). No significant differences were observed between the two groups in terms of visual, refractive, and keratometric outcomes at any time point. No intraoperative or postoperative complications were observed in any of the study groups. Conclusion: Both the 325-degree ICRS and the 340-degree ICRS effectively and equally improved visual, refractive, and keratometric outcomes in keratoconic eyes.

12.
J Clin Med ; 12(4)2023 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-36836208

RESUMO

Purpose: The aim of this study is to describe visual outcomes and epithelial remodeling following the implantation of asymmetric intracorneal ring segments (ICRSs) of variable thickness and base width for the management of duck-type keratoconus. Methods: A prospective observational study of patients with duck-type keratoconus was conducted. All patients received one ICRS AJL PRO + implant (AJL Ophthalmic). We analyzed demographic and clinical data, anterior segment optical coherence tomography (AS-OCT) data and Scheimpflug camera images obtained with a Placido disc MS-39 (CSO, Firenze, Italy) one and six months after surgery to determine keratometric and aberrometric outcomes and epithelial remodeling. Results: We studied 33 keratoconic eyes. ICRS implantation significantly improved both corrected distance visual acuity (CDVA) and uncorrected distance visual acuity at six months, as assessed with the logMAR (minimum angle of resolution) system, from 0.32 ± 0.19 to 0.12 ± 0.12 (p < 0.001) and from 0.75 ± 0.38 to 0.37 ± 0.24 (p < 0.001), respectively. Overall, 87% of implanted eyes gained ≥ 1 line of CDVA, and 3% of patients (n = 1) lost one line of CDVA; 55% of eyes attained a manifest refraction spherical equivalent between +1.50 and -1.50 D. Epithelial remodeling was greater at the wider and thicker end (+11.33 µm ± 12.95; p < 0.001 relative to the initial value) than at the narrower and thinner end (+2.24 µm ± 5.67; p = 0.01). Coma aberration was significantly reduced from 1.62 ± 0.81 µm to 0.99 ± 0.59 µm (p < 0.001). Conclusions: AJL-PRO + ICRS implantation for duck-type keratoconus improves refractive, topographic, aberrometric and visual parameters and induces progressive epithelial thickening along the segment.

13.
Life (Basel) ; 13(4)2023 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-37109508

RESUMO

Confirming the progression of keratoconus is of paramount relevance to providing the appropriate treatment. Real change should be considered consistent over time. It must be greater than the variability of the measurement of the device used to monitor the cornea. The present study aimed to assess the intraobserver repeatability and intersession reproducibility of a Scheimpflug camera in measuring corneal parameters in virgin keratoconus and intrastromal corneal ring segments (ICRS) implantation eyes to discriminate real change from measurement noise. Sixty keratoconus and 30 ICRS eyes were included. Corneal parameters were determined in three consecutive measurements and were repeated 2 weeks later. The precision within the same session for all parameters was better in the keratoconic eyes, with mean repeatability limits 33% narrower (range 13% to 55%) compared with ICRS eyes. Mean reproducibility limits were 16% narrower (range +48% to -45%) compared with ICRS eyes. The cutoff values to consider a real corneal shape change were lower for virgin keratoconic than for ICRS, except for the thinnest corneal thickness and Stage C (ABCD system), which were the opposite. Corneal tomography measurements in ICRS eyes showed worse accuracy than in virgin keratoconus, which should be taken into account by practitioners in patients' follow up.

14.
Eur J Ophthalmol ; 33(1): NP42-NP46, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34730026

RESUMO

AIM: to report late visual, refractive, and tomographic findings of a patient with progressive keratoconus (KCN) over 7-year follow-up examinations after treatment with an advanced intrastromal implant known as annular intracorneal inlay (AICI) combined with accelerated corneal cross-linking (ACXL). METHODS: Slit-lamp photography of anterior segment, corneal tomography maps, and manifest refractions were recorded. RESULTS: A 30-year-old female presented with the complaint of gradual decreased visual acuity in recent years that was remarkable in her left eye (LE). After clinical examinations, she underwent AICI implantation plus ACXL on her LE. Seven years later, notable improvements were observed in some visual, refractive, and tomographic parameters. The most obvious change was ascribed to the uncorrected distance visual acuity (UDVA) that was 1.3logMAR and 0.4logMAR, before and 7 years after the operation, respectively. However, the preoperative corrected distance visual acuity (CDVA) improved slightly from 0.3logMAR to 0.22logMAR after 7 years. The values of anterior K-max, mean-K, flat-K, and steep-K were flattened by 1.80 D, 1.10 D, 1.00 D, and 1.30 D, respectively. Most visual, refractive, and tomographic data improved or remained stable after 7 years and no remarkable ocular complication was observed at the end of the 7th year. CONCLUSION: AICI implantation plus ACXL could be considered as a safe and effective strategy in halting the KCN progression and improving the visual and tomographic properties of the KCN patients. However, future prospective studies with more participants are needed to evaluate the potential effect of AICI implantation on KCN progression.


Assuntos
Ceratocone , Implantação de Prótese , Humanos , Feminino , Adulto , Implantação de Prótese/métodos , Seguimentos , Crosslinking Corneano , Estudos Prospectivos , Substância Própria/cirurgia , Topografia da Córnea , Refração Ocular , Ceratocone/tratamento farmacológico , Reagentes de Ligações Cruzadas/uso terapêutico
15.
Saudi J Ophthalmol ; 36(1): 64-69, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35971492

RESUMO

PURPOSE: To evaluate the causes and long-term outcomes after intrastromal corneal ring segment (ICRS) explantation in the King Khaled Eye Specialist Hospital. METHODS: This was retrospective cohort study. Two groups were analyzed: Group one, ICRS surgery done in our hospital (n = 41) and group two, surgery done outside but removed in our hospital (n = 29). Causes and postoperative management after ICRS removal were analyzed. For statistical analysis, groups were analyzed into two subgroups of causes of ICRS removal: Visual disturbance versus extrusion/infection/neovascularization (NV) subgroups; and two subgroups of postoperative treatment: Corneal transplant (CT) versus Contact lens (CL)/eyeglasses subgroups. RESULTS: The most common cause of ICRS removal in group one was visual disturbance (45.2%) while in group two was extrusion (41.2%). CL is the preferable management after explantation. 76% of ICRS removal occurred during the first 4 years. In group 1, there was significant worse preimplantation visual acuity (P = 0.02) in CT subgroup versus CL/eyeglasses. CT subgroup had lower pachymetry of 437.4 µm (P = 0.04) and higher myopia of 8.05 (P = 0.03) than CL/eyeglasses subgroup. For group two, there was a significant improvement in uncorrected visual acuity in visual disturbances subgroup after explantation (P = 0.004). After explantation, visual disturbances subgroup had higher myopia -4.4 than extrusion subgroup -1.15 (P = 0.004). CONCLUSION: Seventy-six percent of ICRS removal occurred during the first 4 years. High myopia and pachymetry lower than 437 um were associated with visual disturbances and further management with corneal transplantation. High myopia was also associated with visual disturbances in surgeries done outside our hospital.

16.
Vision (Basel) ; 6(4)2022 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-36548938

RESUMO

Intrastromal corneal ring segments (ICRS) improve corneal topographic symmetry and reduce corneal aberrations through regularization of the corneal surface, thereby functioning as a viable surgical intervention for patients with keratoconus. This study aims to evaluate changes in lower- (LOAs) and higher-order aberrations (HOAs) amongst varying pupil sizes pre- and post- ICRS implantation in keratoconus patients. We specifically investigate the impact of pupil size on total corneal HOAs up to the 6th order. Twenty-one eyes that underwent ICRS implantation were included in this prospective interventional study. LOAs and HOAs measurements at the 6 mm, 4 mm, and 2 mm pupil diameters were collected preoperatively and at 6 months postoperatively using the Zernicke analysis function on a Scheimpflug device. ICRS implantation demonstrated a statistically significant effect in vertical coma with a −0.23 reduction (p = 0.015) for a 4 mm pupil size and a −1.384 reduction (p < 0.001) for 6 mm, with no significant effect at 2 mm. Horizontal coma, astigmatism 0°, astigmatism 45°, trefoil 5th order 30°, and RMS HOA demonstrated significant reductions at 4 mm or 6 mm pupil sizes but not at 2 mm. Our analysis demonstrates a favorable effect of ICRS implantation on larger pupil sizes, suggesting the importance of pupil size as it correlates with HOAs reduction.

17.
Front Med (Lausanne) ; 9: 853702, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35360745

RESUMO

Keratoconus is a non-inflammatory and degenerative corneal ectasia that determinate progressive steepening of paracentral cornea with development of irregular astigmatism and visual function deterioration. According to the stage of the pathology, different methods of correction can be used: rigid contact lenses may be used to alter corneal shape and partially correct astigmatism, corneal collagen cross-linking (CXL) and intrastromal corneal ring segment (ICRS) implantation can reinforce corneal stroma to slow disease progression. Late-stage treatment comprehend anterior lamellar keratoplasty or penetrating keratoplasty. We evaluated a 31-year-old patient who was subjected to bilateral ICRS implantation combined with CXL due to keratoconus. This led, after 9 months, to ring extrusion in his left eye, corneal thinning and microperforation into the aqueous chamber with residual irregular astigmatism of 4.50 D. cyl. 10°. The patient underwent ICRS explantation and PKP during the same surgical session. After 15 months of follow-up, the BCVA was 0.2 LogMAR with a residual astigmatism of 6.3 dpt.

18.
Eur J Ophthalmol ; 32(1): 176-182, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33579160

RESUMO

PURPOSE: To evaluate and compare visual and refractive outcomes after implantation of the intracorneal continuous ring 360° arc (ICCR) versus the intracorneal ring segment 340° arc (ICRS) using femtosecond laser for central keratoconus. SETTING: Research Department, Oftalmosalud, Instituto de Ojos, Lima, Peru. METHODS: Randomized study that included 40 eyes of 32 patients diagnosed with central keratoconus between November 2014 and March 2015. Twenty eyes had an implantation of ICCR (MyoRing, Dioptex GmbH, Austria) through an intrastromal pocket and 20 eyes had an implantation of ICRS (Keraring, Mediphacos, Brazil) through an intrastromal tunnel. Both procedures were performed with a femtosecond laser (LDV Z6 model, Ziemer Ophthalmic Systems AG). Visual acuity (VA), refraction, and Scheimpflug imaging analysis were performed pre- and postoperatively at 1 month and 1 year. Comparisons of means were performed using the Student's t-test. RESULTS: At 1 year, uncorrected VA improved 0.77 LogMAR (p < 0.001) in the ICCR group and 0.79 LogMAR (p = 0.01) in the ICRS group; mean sphere improvement was 5.13 Diopters (D) in the ICCR group and 6.27 D in the ICRS group (p < 0.001 both); mean Steeper Keratometry improvement was 4.24 D in the ICCR group and 5.53 D in the ICRS group (p < 0.001 both). In the ICCR group, mean decrease in the pachymetry at the thinnest point of the cornea was 32.16 µm (p = 0.01), and in the ICRS group, mean increase was 4.2 µm at 1 year (p = 0.61). CONCLUSION: Intracorneal continuous ring 360° arc (ICCR) and intracorneal ring segment 340° (ICRS) are effective treatments for central keratoconus. No significant differences between rings were found on visual acuity, refraction, and keratometry improvement.


Assuntos
Substância Própria , Ceratocone , Substância Própria/cirurgia , Topografia da Córnea , Humanos , Ceratocone/cirurgia , Lasers , Próteses e Implantes , Implantação de Prótese , Refração Ocular , Estudos Retrospectivos
19.
Eur J Ophthalmol ; 32(1): 43-49, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34472983

RESUMO

PURPOSE: To compare different intraocular pressure (IOP) readings in corneas with intrastromal corneal ring segments (ICRS) taken by three different tonometers; Goldmann applanation tonometry (GAT), air puff tonometer, and ocular response analyzer (ORA) corneal-compensated IOP (ORA-IOPcc) and determine the relation of these measurements to different corneal parameters taken by Pentacam. METHODS: An observational cross-sectional analytic study included patients who underwent ICRS keraring implantation at 3 months. In each eye, the two rings were placed using the femtosecond laser assisted technique 5.5 or 6 mm from the center. IOP was measured using three different tonometers; GAT, air puff tonometer, and ocular response analyzer (ORA) corneal-compensated IOP (ORA-IOPcc). RESULTS: Fifty eyes of 30 patients (20 males and 10 females) aged 27.56 ± 6.38 years were included. IOP measurements by GAT, air puff tonometer, and ORA-IOPcc were 13.28 ± 2.13 mmHg, 10.47 ± 2.55 mmHg, and 13.19 ± 2.78 mmHg, respectively. Comparisons between air puff and each of GAT and ORA-IOPcc were statistically highly significant (p-value <0.001). CONCLUSION: IOP measurements taken by air puff tonometer were significantly lower than those taken by GAT and ORA-IOPcc. These differences were not constant across the pressure range but increased as the pressure values determined using GAT and ORA increased. ORA-IOPcc and GAT showed similar readings. No correlation was found between any of the IOP readings taken by the three tonometers and the central corneal thickness.


Assuntos
Pressão Intraocular , Tonometria Ocular , Córnea , Estudos Transversais , Feminino , Humanos , Masculino , Próteses e Implantes
20.
J Fr Ophtalmol ; 45(10): 1117-1125, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36334941

RESUMO

PURPOSE: To evaluate the safety and visual outcomes of intrastromal corneal ring segment (ICRS) implantation followed by transepithelial phototherapeutic keratectomy (te-PTK) and corneal cross-linking (CXL) in patients with mild keratoconus. METHODS: Patients with mild keratoconus and contact lens intolerance who underwent sequential ICRS implantation followed by phototherapeutic keratectomy and corneal CXL between April 2015 and July 2018 were retrospectively included in the study. Refractive and visual outcomes, satisfaction questionnaire and complications were recorded at the last follow-up (mean 9.5 months postoperatively). RESULTS: Twenty eyes of 17 patients were enrolled, including 5 women and 15 men. The mean time between the two procedures was 16 months. Based on values before the first procedure and 9.5 months after the second procedure, significant improvements were noted in uncorrected distance visual acuity (UDVA) (0.80±0.35 logMAR vs. 0.46±0.38 logMAR), corrected distance visual acuity (CDVA) (0.38±0.23 logMAR vs. 0.13±0.16 logMAR), maximal K (56.11±4 diopters [D] vs. 50.6±3.56 D), mean K (51.87±3.43 D vs. 48.45±2.91 D), cylinder (7.99±3.94 D vs. 4.23±3.49 D), and spherical equivalent (-3.84±3.36 D vs. -0.99±2.15 D) (P<0.01). Among the outcomes, we noted 5 (25%) superficial corneal scarring (haze); 75% of eyes gained>=1 logMAR line of CDVA. In all, 94.5% of patients reported that they were satisfied with their outcomes. CONCLUSION: Combining ICRS implantation followed by te-PTK and corneal CXL appears to be a safe and effective approach for improving visual outcomes and quality of life in keratoconus patients.


Assuntos
Ceratocone , Feminino , Masculino , Humanos , Ceratocone/cirurgia , Qualidade de Vida , Estudos Retrospectivos , Ceratectomia , Córnea
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