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Lipids Health Dis ; 23(1): 88, 2024 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-38528544

RESUMO

The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic differentiation of mesenchymal stem cells residing in the bone marrow, ultimately playing a role in the development of osteoporosis (OP). Mitigating ROS levels is a promising approach to counteracting OP. In this study, a nanozyme composed of magnesium-based zeolitic imidazolate frameworks (Mg-ZIF) was engineered to effectively scavenge ROS and alleviate OP. The results of this study indicate that Mg-ZIF exhibits significant potential in scavenging ROS and effectively promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs). Additionally, Mg-ZIF was found to inhibit the differentiation of BMSCs into adipose cells. In vivo experiments further confirmed the ability of Mg-ZIF to mitigate OP by reducing ROS levels. Mechanistically, Mg-ZIF enhances the differentiation of BMSCs into osteoblasts by upregulating lipid metabolic pathways through ROS scavenging. The results indicate that Mg-ZIF has potential as an effective therapeutic approach for the treatment of osteoporosis.


Assuntos
Células-Tronco Mesenquimais , Osteoporose , Humanos , Osteogênese/genética , Magnésio , Metabolismo dos Lipídeos/genética , Espécies Reativas de Oxigênio/metabolismo , Células Cultivadas , Diferenciação Celular , Osteoporose/tratamento farmacológico , Osteoporose/genética , Osteoporose/metabolismo , Células da Medula Óssea
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