Fourth-Order Quadratic Buck Converter Controller Design.

This paper aims to outline the process of dimensioning a controller tailored for a fourth-order step-down converter. In order to conduct a thorough small-signal analysis, it is imperative to find the state-space model in matrices form. Given its fourth-order nature, the control-to-output transfer function also aligns with this order, although its degree is ultimately reduced to a second-order using the tfest function. It is remarkable that the design of the type III error amplifier assumes a central position in the overall controller design process. The theoretical analysis was then subjected to rigorous validation via simulation, with particular attention paid to the step response in both input voltage and output resistance. This study developed from the desire to validate the efficacy of reducing the control-to-output transfer function degree using the tfest function, aiming to highlight a fourth-order converter to which controller design theory can be applied, related to that for a second-order converter.

Association between road traffic accidents and drugs belonging to the antiseizure medications class: A pharmacovigilance analysis in VigiBase.

AIMS: Due to their central mechanism of action, antiseizure medications (ASMs) could lead to adverse effects likely to impair driving skills. Their extended use to neuropsychiatric disorders makes it a class of drugs to monitor for their road traffic accidental (RTA) potential. We aimed to assess the reporting association between ASMs and RTAs using the World Health Organization pharmacovigilance database (VigiBase). METHODS: We performed a disproportionality analysis to compute adjusted reporting odds ratios to evaluate the strength of reporting association between ASMs and RTAs. A univariate analysis using the reporting odds-ratio was used to assess drug-drug interactions between ASMs and RTAs. RESULTS: There were 1 341 509 reports associated with at least 1 ASM in VigiBase of whom 2.91‰ were RTAs reports. Eight ASMs were associated with higher reporting of RTAs compared to others (ranging from 1.35 [95% confidence interval 1.11-1.64] for lamotrigine to 4.36 [95% confidence interval 3.56-5.32] for cannabis). Eight significant drug-drug interactions were found between ASMs and the onset of RTA, mainly involving CYP450 induction. CONCLUSION: A significant safety signal between RTAs and some ASMs was identified. Association of several ASMs might further increase the occurrence of RTA. ASMs prescription in patients with identified risk factors of RTA should be considered with caution. Study number: ClinicalTrials.gov, NCT04480996.

PCB-Based Planar Inductive Loops for Partial Discharges Detection in Power Cables.

Partial discharge (PD) diagnosis tests, including detecting, locating, and identifying, are used to trace defects or faults and assess the degree of aging in order to monitor the insulation condition of medium- and high-voltage power cables. In this context, an experimental evaluation of three different printed circuit board (PCB)-based inductive sensor topologies, with spiral, non-spiral, and meander shapes, is performed. The aim is to assess their capabilities for PD detection along a transmission power cable. First, simulation and experimental characterization are carried out to determine the equivalent electrical circuit and the quality factor of the three sensors. PD activity was studied in the lab on a 10-m-long defective MVAC cable. The three PCB-based sensors were tested in three different positions: directly on the defective cable (P1), at a separation distance of 10 cm to 3 m (P2), and on the ground line (P3). For the three positions, all sensors' outputs present a damped sine wave signal with similar frequencies and durations. Experimental results showed that the best sensitivity was given by the non-spiral inductor, with a peak voltage of around 500 mV in P1, 428 mV in P2, and 45 mV in P3, while the meander sensor had the lowest values, which were approximately 80 mV in P1. The frequency spectrum bandwidth of all sensors was between 10 MHz and 45 MHz. The high sensitivity of the non-spiral inductor could be associated with its interesting properties in terms of quality factor and SFR, which are due to its very low resistivity. To benchmark the performance of the designed three-loop sensors, a comparison with a commercial high-frequency current transformer (HFCT) is also made.

Variation Range of Different Inductor Topologies with Shields for RF and Inductive Sensing Applications.

In this study, different planar inductor topologies were studied to evaluate their characteristic parameters' variation range upon approaching Fe- and Cu-based shield plates. The use of such materials can differently alter the electrical properties of planar inductors such as the inductance, resonant frequency, resistance, and quality factor, which could be useful in multiple devices, particularly in inductive sensing and radio-frequency (or RF) applications. To reach an optimal design, five different square topologies, including spiral, tapered, non-spiral, meander, and fractal, were built on a printed circuit board (PCB) and assessed experimentally. At the working frequency of 1 MHz, the results showed a decrease in the inductance value when approaching a Cu-based plate and an increase with Fe-based plates. The higher variation range was noticeable for double-layer topologies, which was about 60% with the Cu-based plate. Beyond an intrinsic deflection frequency, the inductance value began to decrease when approaching the ferromagnetic plate because of the ferromagnetic resonance (FMR). It has been shown that the FMR frequency depends on the inductor topology and is larger for the double-layer spiral one. The Q-factor was decreasing for all topologies but was much faster when using ferromagnetic plates because of the FMR, which intensely increases the track resistance. The resonant frequency was increasing for all double-layer topologies and decreasing for single-layer ones, which was mainly due to the percentage change in the stray capacitance compared to the inductance variation. The concept of varying inductors by metal shielding plates has great potential in a wide range of nondestructive sensing and RF applications.

Experimental Anxiety Model for Anxiety Disorders: Relevance to Drug Discovery.

This chapter describes the various animal models that seem relevant to the development of anxiolytic drugs, as well as the human models of induced anxiety, or more precisely the panic inducers including cholecystokinin. It is also mentioned the theoretical model of Deakin and Graeff which seems to keep all its relevance. The knock animals are evoked as relevant tools as well as a new optogenetic technique that needs to be used in this field.

A review on MnZn ferrites: Synthesis, characterization and applications.

Researchers are taking great interest in the synthesis and characterization of MnZn ferrites due to their wide range of applications in many areas. MnZn ferrites are a class of soft magnetic materials that have very good electrical, magnetic and optical properties. The properties of MnZn ferrites include high value of resistivity, permeability, permittivity, saturation magnetization, low power losses and coercivity. The above mentioned advantageous features of MnZn ferrites make them suitable for the use in various applications. In biomedical field these ferrites are used for cancer treatment and MRI. MnZn ferrites are also used in electronic applications for making transformers, transducers and inductors. These ferrites are also used in magnetic fluids, sensors and biosensors. MnZn ferrite is highly useful material for several electrical and electronic applications. It finds applications in almost every household appliances like mobile charger, LED bulb, TV, refrigerator, juicer mixer, washing machine, iron, microwave oven, mobile, laptop, desktop, printer and so on. Therefore, the present review focuses on different techniques for synthesis of MnZn ferrites in literature, their characterization tools, effect of doping on the properties of MnZn ferrite and finally we will discuss about their applications.

Activation of transposable elements and genetic instability during long-term culture of the human fungal pathogen Candida albicans.

It has been repeatedly reported that transposable elements (TE) become active and/or mobile in the genomes of replicatively and stress-induced senescent mammalian cells. However, the biological role of senescence-associated transposon activation and its occurrence and relevance in other eukaryotic cells remain to be elucidated. In the present study, Candida albicans, a prevalent opportunistic fungal pathogen in humans, was used to analyze changes in gene copy number of selected TE, namely Cirt2, Moa and Cmut1 during long-term culture (up to 90 days). The effects of stress stimuli (fluconazole, hydrogen peroxide, hypochlorite) and ploidy state (haploid, diploid, tetraploid cells) were also considered. An increase in copy number of Cirt2 and Moa was the most accented in tetraploid cells after 90 days of culture that was accompanied by changes in karyotype patterns and slightly more limited growth rate compared to haploid and diploid cells. Stress stimuli did not potentiate TE activity. Elevation in chromosomal DNA breaks was also observed during long-term culture of cells of different ploidy, however this was not correlated with increased TE activity. Our results suggest that increased TE activity may promote genomic diversity and plasticity, and cellular heterogeneity during long-term culture of C. albicans cells.

Fabrication of Circuits on Flexible Substrates Using Conductive SU-8 for Sensing Applications.

This article describes a new low-cost rapid microfabrication technology for high-density interconnects and passive devices on flexible substrates for sensing applications. Silver nanoparticles with an average size of 80 nm were used to create a conductive SU-8 mixture with a concentration of wt 25%. The patterned structures after hard baking have a sheet resistance of 11.17 Ω /□. This conductive SU-8 was used to pattern planar inductors, capacitors and interconnection lines on flexible Kapton film. The conductive SU-8 structures were used as a seed layer for a subsequent electroplating process to increase the conductivity of the devices. Examples of inductors, resistor-capacitor (RC) and inductor-capacitor (LC) circuits, interconnection lines and a near-field communication (NFC) antenna are presented as a demonstration. As an example of high-resolution miniaturization, we fabricated microinductors having line widths of 5 µ m. Mechanical bending tests were successful down to a 5 mm radius. To the best of the authors' knowledge, this is the first report of conductive SU-8 used to fabricate such planar devices and the first on flexible substrates. This is a proof of concept that this fabrication approach can be used as an alternative for microfabrication of planar passive devices on flexible substrates.

In Vitro Study of Cytophysiological Characteristics of Multinuclear Macrophages from Intact and BCG-Infected Mice.

Peritoneal macrophages were isolated from intact and BCG-infected BALB/c mice and explanted in vitro. Multinuclear macrophages formed in these cultures differed by the number of nuclei, expression of apoptosis inductors and regulators (TNF-α, p53 protein, caspase 3, and Bcl-2 protein), and cytophysiological characteristics (phagocytic activity, ROS generation, and antimycobacterial properties). Our results indicate that the formation of multinuclear macrophages is accompanied by induction of apoptosis (p53 signaling pathway) and appearance of multinuclear macrophage-derived cells characterized by high phagocytic and antimycobacterial activity.

[The sanitation of staphylococcus bacteria carrying: new possibilities and perspectives.]

The study was carried out to investigate possibility of applying biologically active substances - interferon inductors - for increasing effectiveness of prevention and treatment of torpid forms of infectious process, staphylococcus bacteria carrying in particular, considering effectiveness of their effect on biological characteristics of Staphylococcus aureus. The data are obtained concerning character of effect of pharmaceuticals on persistent characteristics of staphylococcus. These results can be applied in selection of new perspective preparations for sanitation of staphylococcus bacteria carrying.

Polymer-Assisted 3D Printing of Inductor Cores.

Poly(glycerol monomethacrylate) (PGMA) prepared by reversible addition-fragmentation chain transfer polymerization was investigated as an additive for high-loading iron oxide nanoparticle (IOP) 3D printable inks. The effect of adjusting the molar mass and loading of PGMA on the rheology of IOP suspensions was investigated, and an optimized ink formulation containing 70% w/w IOPs and 0.25% w/w PGMA98 at pH 10 was developed. This ink was successfully 3D printed onto various substrates and into several structures, including rectangles, high aspect ratio cylinders, letters, spiral- and comb-shaped structures, and thin- and thick-walled toroids. The effect of sintering on the mechanical properties of printed artifacts was investigated via four-point flexural and compressive testing, with higher sintering temperatures resulting in improved mechanical properties due to changes in the particle size and microstructure. The printed toroids were fabricated into inductors, and their electrical performance was assessed via impedance spectroscopy at a working frequency range of 0.001-13 MHz. There was a clear trade-off between electrical properties and sintering temperature due to a phase change between γ-Fe2O3 and α-Fe2O3 upon heating. Nevertheless, the optimized devices had a Q factor of ∼40 at 10 MHz, representing a superior performance compared to that of other inductors with iron oxide cores previously reported. Thus, this report represents a significant step toward the development of low-cost, fully aqueous, high loading, and 3D printable ceramic inks for high-performance inductors and functional devices.

On thermal characterization method of integrated magnetic components.

The operating temperature of integrated magnetic components can be critical. Excessively high temperature can significantly modify the properties of components, especially those of magnetic material, such as saturation magnetization and magnetic permeability. This article introduces an experimental characterization method using two different sensors. We compare the results obtained from these sensors. Initially, the method is validated using a "meander component, and subsequently, it is applied to planar spiral inductors, both with and without magnetic material.

Mechanical Response of MEMS Suspended Inductors under Shock Using the Transfer Matrix Method.

MEMS suspended inductors are susceptible to deformation under external forces, which can lead to the degradation of their electrical properties. The mechanical response of the inductor to a shock load is usually solved by a numerical method, such as the finite element method (FEM). In this paper, the transfer matrix method of linear multibody system (MSTMM) is used to solve the problem. The natural frequencies and mode shapes of the system are obtained first, then the dynamic response by modal superposition. The time and position of the maximum displacement response and the maximum Von Mises stress are determined theoretically and independently of the shock. Furthermore, the effects of shock amplitude and frequency on the response are discussed. These MSTMM results agree well with those determined using the FEM. We achieved an accurate analysis of the mechanical behaviors of the MEMS inductor under shock load.

Development and Applications of Embedded Passives and Interconnects Employing Nanomaterials.

The advent of nanotechnology has initiated a profound revolution in almost all spheres of technology. The electronics industry is concerned with the ongoing miniaturization of devices and as such requires packaging technologies that will make the devices more compact and resilient. 3D packaging, system in package, and system on chip are the various packaging techniques that utilize nanoscale components for their implementation. The active components of the ICs have kept pace with Moore's law, but the passive components have proven an impediment in the race for miniaturization. Moreover, the toxic effects and nano-scale problems associated with conventional soldering techniques have entailed the active involvement of nanotechnology in the search for answers. Recent advances in these fields and the diverse nanomaterials which are being employed to resolve these issues have been discussed in detail.

Power Losses Models for Magnetic Cores: A Review.

In power electronics, magnetic components are fundamental, and, unfortunately, represent one of the greatest challenges for designers because they are some of the components that lead the opposition to miniaturization and the main source of losses (both electrical and thermal). The use of ferromagnetic materials as substitutes for ferrite, in the core of magnetic components, has been proposed as a solution to this problem, and with them, a new perspective and methodology in the calculation of power losses open the way to new design proposals and challenges to overcome. Achieving a core losses model that combines all the parameters (electric, magnetic, thermal) needed in power electronic applications is a challenge. The main objective of this work is to position the reader in state-of-the-art for core losses models. This last provides, in one source, tools and techniques to develop magnetic solutions towards miniaturization applications. Details about new proposals, materials used, design steps, software tools, and miniaturization examples are provided.

Power Molding Inductors Prepared Using Amorphous FeSiCrB Alloy Powder, Carbonyl Iron Powder, and Silicone Resin.

In this study, amorphous FeSiCrB alloy powder, carbonyl iron powder, and high-temperature heat-resistant silicone resin were used to prepare power molding inductors, and the effects of different heat treatment procedures on the magnetic properties were investigated. Two heat treatment procedures were used. Procedure 1: Amorphous FeSiCrB alloy powder was pre-heat-treated, then mixed with carbonyl iron powder and silicone resin and uniaxially pressed to prepare power inductors. Procedure 2: A mixture of amorphous FeSiCrB alloy powder, carbonyl iron powder, and silicone resin was uniaxially pressed. After dry pressing, the compacted body was heat-treated at 500 °C. Heat treatment after compaction can reduce the internal strain caused by high-pressure compaction and promote the crystallization of superparamagnetic nano-grains simultaneously. Therefore, the compacted sample after heat treatment exhibited better magnetic properties.

Reactive Oxygen, Nitrogen, and Sulfur Species (RONSS) as a Metabolic Cluster for Signaling and Biostimulation of Plants: An Overview.

This review highlights the relationship between the metabolism of reactive oxygen species (ROS), reactive nitrogen species (RNS), and H2S-reactive sulfur species (RSS). These three metabolic pathways, collectively termed reactive oxygen, nitrogen, and sulfur species (RONSS), constitute a conglomerate of reactions that function as an energy dissipation mechanism, in addition to allowing environmental signals to be transduced into cellular information. This information, in the form of proteins with posttranslational modifications or signaling metabolites derived from RONSS, serves as an inducer of many processes for redoxtasis and metabolic adjustment to the changing environmental conditions to which plants are subjected. Although it is thought that the role of reactive chemical species was originally energy dissipation, during evolution they seem to form a cluster of RONSS that, in addition to dissipating excess excitation potential or reducing potential, also fulfils essential signaling functions that play a vital role in the stress acclimation of plants. Signaling occurs by synthesizing many biomolecules that modify the activity of transcription factors and through modifications in thiol groups of enzymes. The result is a series of adjustments in plants' gene expression, biochemistry, and physiology. Therefore, we present an overview of the synthesis and functions of the RONSS, considering the importance and implications in agronomic management, particularly on the biostimulation of crops.

Laser Direct Structured 3D Circuits on Silicone.

Silicone rubber is a biocompatible elastomeric polymer, with great potential for mechanical and biologic sensing applications, if electrical circuits can be reliably integrated. Laser direct structuring is a bottom-up circuit fabrication process, whereby copper is chemically grown on laser exposed regions of a modified substrate, promoting adhesion by laser roughening the circuit tracks. In this Research Article, we successfully demonstrate this process using superflexible biocompatible silicone (30 hardness on Shore 00) with copper chromite additive, cast into both 2D planar and 3D contour substrates. A horseshoe pattern circuit, meander and Hilbert fractal inductors, and a 3D hemispherical helix trace are fabricated and tested. The range of laser power and copper chromite concentration are explored. Mechanical testing is performed to determine breakage strain and elastic modulus. Material stiffness and trace peel strength are shown to increase with copper chromite concentration. Peel strength is measured to be very high, from approximately 1 to 5 kN/m, depending on dopant loading. With high adhesion and conductivity, the simple laser-writing process presented here enables high-quality circuit integration into elastomeric silicone.

Status of ALS Treatment, Insights into Therapeutic Challenges and Dilemmas.

Amyotrophic lateral sclerosis (ALS) is an extremely heterogeneous disease of motor neurons that eventually leads to death. Despite impressive advances in understanding the genetic, molecular, and pathological mechanisms of the disease, the only drug approved to date by both the FDA and EMA is riluzole, with a modest effect on survival. In this opinion view paper, we will discuss how to address some challenges for drug development in ALS at the conceptual, technological, and methodological levels. In addition, socioeconomic and ethical issues related to the legitimate need of patients to benefit quickly from new treatments will also be addressed. In conclusion, this brief review takes a more optimistic view, given the recent approval of two new drugs in some countries and the development of targeted gene therapies.

Wireless Micro Soft Actuator without Payloads Using 3D Helical Coils.

To receive a greater power and to demonstrate the soft bellows-shaped actuator's wireless actuation, micro inductors were built for wireless power transfer and realized in a three-dimensional helical structure, which have previously been built in two-dimensional spiral structures. Although the three-dimensional helical inductor has the advantage of acquiring more magnetic flux linkage than the two-dimensional spiral inductor, the existing microfabrication technique produces a device on a two-dimensional plane, as it has a limit to building a complete three-dimensional structure. In this study, by using a three-dimensional printed soluble mold technique, a three-dimensional heater with helical coils, which have a larger heating area than a two-dimensional heater, was fabricated with three-dimensional receiving inductors for enhanced wireless power transfer. The three-dimensional heater connected to the three-dimensional helical inductor increased the temperature of the liquid and gas inside the bellows-shaped actuator while reaching 176.1% higher temperature than the heater connected to the two-dimensional spiral inductor. Thereby it enables a stroke of the actuator up to 522% longer than when it is connected to the spiral inductor. Therefore, three-dimensional micro coils can offer a significant approach to the development of wireless micro soft robots without incurring heavy and bulky parts such as batteries.