'All the progressive forms of life are built up on the attraction of sex': Development and the social function of the sexual instinct in late 19th- and early 20th-century Western European sexology.

This article explores the relationship between sexual science and evolutionary models of human development and progress. It examines the ways in which late 19th- and early 20th-century Western European sexual scientists constructed the sexual instinct as an evolutionary force that not only served a reproductive purpose, but was also pivotal to the social, moral, and cultural development of human societies. Sexual scientists challenged the idea that non-reproductive sexualities were necessarily perverse, pathological, or degenerative by linking sexual desire to the evolution of sociality, often focusing on forms of relationality and care that exceeded biological kinship. As a result, non-reproductive sexual expressions, including homosexual and non-reproductive heterosexual behaviours, were interpreted as manifestations of a sexual instinct operating in the service of human development. These claims were reliant on cross-cultural and historical comparisons of sexual values, behaviours, and customs that rehearsed and reinforced imperial narratives of development premised on racialized, gendered, and classed hierarchies. Sexual scientists mapped diverse sexual behaviours in terms of their perceived evolutionary benefits, contributing to colonial narratives that distinguished between different cultures according to imagined trajectories of development. These contestations around the sexual instinct and its developmental functions played a vital role in allowing sexual science to authorize itself as a field of knowledge that promised to provide expertise required to manage sexual life and secure the global development of human civilization.

The unwelcome child and a lack of acceptance of new ideas.

Ferenczi's idea of the unwelcome child and his death instinct is used as a background for discussing the treatment of adult patients who do not expect to be received and understood and who turn their aggression back upon themselves, destroying their will to live. When these patients enter analysis, they are very difficult to reach because they have internalized an obstructive object (Bion, 1958). Further, I have linked the unwelcoming of a child to the hatred of the new idea. The paper highlights the deadening defenses that arise in response to awareness of premature separateness between mother and baby, inevitably experienced by an unwelcome child. Coming alive involves suffering the pain of the original loss. To avoid this pain, patients reject anything new, and become stuck in monotonous, seemingly lifeless, patterns where new ideas and new ways of being threaten the static order. This includes the threat that relationship with the analyst brings.

The Unwelcome Child as a Dynamic Construct of the Terrorist Mind.

Psychoanalytic discourse on the dynamics of the terrorist mindset has been challenged by the absence of clinical work with terrorists in the literature. This paper proposes Ferenczi's concept of the unwelcome child as a dynamic construct of the terrorist mind. Unwelcome children have weak life instincts and correspondingly high death instincts. Clinical material from the analysis of an unwelcome child is presented which suggests that a sense of anomie and alienation from social ties may lead to a fundamentalist mind set which may potentially lead to a search for meaning in terrorist acts. The struggle between life and death instincts is demonstrated in the clinical material, with life instinct tipping the scales in this instance. Self-preservative survival instinct is proposed as the theoretical construct for life instinct in contrast to Freud's libido theory. The unwelcome child represents an object relations theory of the death instinct. Unwelcome children are likely a widespread phenomenon with significant social consequences.

Understanding the "gut instinct" of expert coaches during talent identification.

Coaches are an integral part of talent identification in sport and are often used as the "gold standard" against which scientific methods of talent identification are compared. However, their decision-making during this process is not well understood. In this article, we use an ecological approach to explore talent identification in combat sports. We interviewed twenty-four expert, international-level coaches from the Olympic disciplines of boxing, judo, and taekwondo (age: 48.7 + 7.5 years; experience: 20.8 + 8.3 years). Findings indicated that when coaches identify talent they rely on "gut instinct": intuitive judgements made without conscious thought, used to direct attention to particular athletes or characteristics. Our analysis revealed four major contributors to coaches' intuition: experiential knowledge, temporal factors, seeing athletes in context, and what can be worked with. Our findings demonstrate that i) athlete selections may be influenced by the coaches' perceived ability to improve certain athletes (rather than solely on athlete ability); and ii) "instinctual" decisions are the result of years of experience, time spent with the athlete, and the context surrounding the decision. Based on these findings, we recommend that future research focuses on the duration and conditions that are required for coaches to confidently and reliably identify talented athletes.

Who's afraid of epigenetics? Habits, instincts, and Charles Darwin's evolutionary theory.

Our paper aims at bringing to the fore the crucial role that habits play in Charles Darwin's theory of evolution by means of natural selection. We have organized the paper in two steps: first, we analyse value and functions of the concept of habit in Darwin's early works, notably in his Notebooks, and compare these views to his mature understanding of the concept in the Origin of Species and later works; second, we discuss Darwin's ideas on habits in the light of today's theories of epigenetic inheritance, which describe the way in which the functioning and expression of genes is modified by the environment, and how these modifications are transmitted over generations. We argue that Darwin's lasting and multifaceted interest in the notion of habit, throughout his intellectual life, is both conceptually and methodologically relevant. From a conceptual point of view, intriguing similarities can be found between Darwin's (early) conception of habit and contemporary views on epigenetic inheritance. From a methodological point of view, we suggest that Darwin's plastic approach to habits, from his early writings up to the mature works, can provide today's evolutionary scientists with a viable methodological model to address the challenging task of extending and expanding evolutionary theory, with particular reference to the integration of epigenetic mechanisms into existing models of evolutionary change. Over his entire life Darwin has modified and reassessed his views on habits as many times as required by evidence: his work on this notion may represent the paradigm of a habit of good scientific research methodology.

Does the Golem Feel Pain? Moral Instincts and Ethical Dilemmas Concerning Suffering and the Brain.

Pain has variously been used as a means of punishment, extracting information, or testing commitment, as a tool for education and social control, as a commodity for sacrifice, and as a draw for sport and entertainment. Attitudes concerning these uses have undergone major changes in the modern era. Normative convictions on what is right and wrong are generally attributed to religious tradition or to secular-humanist reasoning. Here, we elaborate the perspective that ethical choices concerning pain have much earlier roots that are based on instincts and brain-seated empathetic responses. They are fundamentally a function of brain circuitry shaped by processes of Darwinian evolution. Social convention and other environmental influences, with their idiosyncrasies, are a more recent, ever-changing overlay. We close with an example in which details on the neurobiology of pain processing, specifically the question of where in the brain the experience of pain is generated, affect decision making in end-of-life situations. By separating innate biological substrates from culturally imposed attitudes (memes), we may arrive at a more reasoned approach to a morality of pain prevention.

If Engrams Are the Answer, What Is the Question?

Engram labelling and manipulation methodologies are now a staple of contemporary neuroscientific practice, giving the impression that the physical basis of engrams has been discovered. Despite enormous progress, engrams have not been clearly identified, and it is unclear what they should look like. There is an epistemic bias in engram neuroscience toward characterizing biological changes while neglecting the development of theory. However, the tools of engram biology are exciting precisely because they are not just an incremental step forward in understanding the mechanisms of plasticity and learning but because they can be leveraged to inform theory on one of the fundamental mysteries in neuroscience-how and in what format the brain stores information. We do not propose such a theory here, as we first require an appreciation for what is lacking. We outline a selection of issues in four sections from theoretical biology and philosophy that engram biology and systems neuroscience generally should engage with in order to construct useful future theoretical frameworks. Specifically, what is it that engrams are supposed to explain? How do the different building blocks of the brain-wide engram come together? What exactly are these component parts? And what information do they carry, if they carry anything at all? Asking these questions is not purely the privilege of philosophy but a key to informing scientific hypotheses that make the most of the experimental tools at our disposal. The risk for not engaging with these issues is high. Without a theory of what engrams are, what they do, and the wider computational processes they fit into, we may never know when they have been found.

Embodied intersubjectivity: Forms of psyche-soma structuring in the encounter between self and other-than-self.

This paper explores the mechanisms that lead to a destructive tendency in the formation and functioning of the psychic apparatus, to the characteristic states of subjects who are drawn to non-life. The dynamics of the primary mother-child relationship involve a structural interaction between mind and body, subject and object. The dialectic between the life drive and the death drive is conceptualized as the structuring of homeostatic dynamic equilibria, in which both drives belong to the living, provided they are kept in a non-isolated system. This conception has analogies with other disciplines that have changed their paradigms, such as neurobiology, which, for living beings in open systems, hypothesises a continuous interconnected Becoming of undivided separation and of discontinuity. In unitary psyche-soma functioning, a dynamic homoeostatic balance marks the state of health of the relating subject; or if, instead, the system is isolated, a pathological dysregulation depending on the emotional-affective vicissitudes it undergoes. Two clinical cases illustrate these dynamics. For this tendency on the level of the somatopsychic unit, the name alloiosis has been put forward, in analogy with cellular apoptosis.

Freud's 1926 conjecture is confirmed: evidence from the dorsal periaqueductal gray in mice that human psychological defense against internal instinctual threat evolved from animal motor defense against external predatory threat.

In 1926, Freud famously conjectured that the human ego defense of repression against an internal instinctual threat evolved from the animal motor defense of flight from an external predatory threat. Studies over the past 50 years mainly in rodents have investigated the neurobiology of the fight-or-flight reflex to external threats, which activates the emergency alarm system in the dorsal periaqueductal gray (dPAG), the malfunction of which appears likely in panic and post-traumatic stress disorders, but perhaps also in some "non-emergent" conditions like social anxiety and "hysterical" conversion disorder. Computational neuroscience studies in mice by Reis and colleagues have revealed unprecedented insights into the dPAG-related neural mechanisms underlying these evolutionarily honed emergency vertebrate defensive functions (e.g., explore, risk assessment, escape, freeze). A psychoanalytic interpretation of the Reis studies demonstrates that Freud's 1926 conjecture is confirmed, and that internal instinctual threats alone can also set off the dPAG emergency alarm system, which is regulated by 5-HT1A and CRF-1 receptors. Consistent with current psychoanalytic and neurobiologic theories of panic, several other of the primitive components of the dPAG alarm system may also have relevance for understanding of the unconscious determinants of impaired object relationships (e.g., avoidance distance). These dPAG findings reveal (1) a process of "evolution in situ," whereby a more sophisticated dPAG ego defense is seen evolving out of a more primitive dPAG motor defense, (2) a dPAG location for the phylogenetically ancient kernel of Freud's Ego and Id, and (3) a Conscious Id theory that has been conclusively invalidated.

Is food preference innate instinct driven or human's free will?

The question whether food preference decisions are controlled by innate instincts, or a conscious decision-making process is still open. The answer to this question is important not only for neuroscientists, psychologists, and philosophers but also for food scientists and developers. Looking from different perspectives involved in food preference decisions could not only settle a long ongoing debate but also pave the way to understand why people prefer to eat what they eat.

The forgotten militant and his enduring mission: Zing-Yang Kuo and his extraordinary years in behavioral neuroembryology (1929-1939).

Zing-Yang Kuo (1898-1970), hailed as China's behaviorist psychologist, earned "Out-Watsons Mr. Watson" in the international anti-instinct movement. His contributions to the field on behavioral neuroembryology (1929-1939) are often overlooked in comparison to his achievements in psychology. We retrieved the titles of all of Kuo's publications from 1929 to 1939 and examined those related to his research on the origins and development of embryonic behavioral ontogeny and the neural basis of embryonic behavior. Remarkably, Kuo concurrently focused on embryos during the same period as North American neuroembryologists. He maintained an independent stance in the debate over the sequence of behavioral ontogeny, represented by the embryonic neuroscientists Coghill and Windle, and critically pointed out limitations in research on both sides of the debate. Drawing from his experiments with chicken embryos, Kuo proposed the theory of behavioral epigenesis, which attempted to end the nature-nurture dichotomy and promote the transformation of the research path of behavioral embryology from elementary physiological anatomy toward a deep "comprehensive science." Kuo's achievements directly laid the foundation for the interdisciplinary field of developmental psychobiology, constructing a new conceptual framework for the systematic analysis of behavioral development and promoting the establishment and development of a new approach to epiphenotype epigenetics.

Validity and Reliability of Wearable Technology Devices during Simulated Pickleball Game Play.

Pickleball is a popular sport. Also popular is wearable technology usage. Because the validity and reliability of wearable technology during pickleball is unknown, the purpose of this research was to evaluate the ability of common devices to return heart rate and estimated energy expenditure during pickleball activity. Twenty adult participants were outfitted with a portable metabolic unit and heart rate monitor (criterion measures). Experimental devices were a Garmin Instinct, Polar Vantage M2, Polar OH1, and Polar Verity Sense. Participants played simulated pickleball for 10 min. Validity measures included mean absolute percent error (MAPE) and Lin's Concordance Correlation Coefficient (CCC), whereas reliability measures included coefficient of variation (CV) and intraclass correlation coefficient (ICC). The heart rate returned lower than 10% MAPE across all devices (Instinct = 5.73-6.32%, Verity Sense = 2.92-2.97%, OH1 = 3.39-3.45%) and greater than 0.85 CCC (Instinct = 0.85-0.88, Verity Sense = 0.96-0.96, OH1 = 0.93-0.94). The CV was below 10% (Instinct = 9.30%, Verity Sense = 2.68%, OH1 = 5.01%), and ICC was above 0.7 (Instinct = 0.77, Verity Sense = 0.98, OH1 = 0.91). The energy expenditure MAPE was greater than 10% (Instinct = 27.67-28.08%, Vantage M2 = 18.87-23.38%) with CCC lower than 0.7 (Instinct = 0.47-0.49, Vantage M2 = 0.62-0.63). Reliability thresholds were met in the Vantage M2 (CV = 6%, ICC = 0.98) but not in the Instinct (CV = 15%, ICC = 0.86). The Instinct was neither valid nor reliable for estimated energy expenditure, while the Polar Vantage M2 was reliable but not valid. All devices returned valid and reliable heart rates during pickleball.

Investigating first instinct fallacy in cytology education and cytomorphology examination.

INTRODUCTION: The specific aims of the study are to assess whether answer changing on a high-stakes cytomorphology examination will lower the cytology examinees' scores and to examine whether there is a difference in the frequency of responses changed between high-, average-, and low-performing cytology learners. The paper also seeks to explore if there is a correlation between outcomes of answer changes (success rates) and cytology learner's levels of performance. MATERIALS AND METHODS: The eraser marks and pen cross-outs on the cytology final image examinations from 2019-2023 were reviewed and the number of changes made by the examinees and the frequency to which scores were raised or lowered as a result was recorded. Moreover, the response change patterns and outcomes across low-, medium-, and high-performing cytology learners were further analyzed for possible relationships. RESULTS: Among the total number of questions where answer(s) were changed (n = 98), close to half (n = 47, 48.0%) of the changes resulted in raising the score, compared with about one-third (n = 34, 34.7%) that lowered it. When the students were classified into academic abilities, there was a significant correlation between the success rates of answers changed across low-, medium-, and higher-performing learners χ2 (df = 24, n = 24) = 10.24, P < 0.05. Our data also showed the average student group to have the highest "scores raised" to "scores lowered" ratio. CONCLUSIONS: Based on these findings, those cytology examinees who are overly cautious about changing initial responses during a high-stake multiple-choice question BOC test may put themselves at a disadvantage.

Jung's Erotic Phenomenology: I. A New Translation.

In the introduction to The Psychology of the Transference (1946), Carl Jung sketched out a theory of "erotic phenomenology" which condenses his teaching about sexuality and romantic love into a very concise summary. But the meaning of this passage is obscured in the English translation given in the Collected Works of C. G. Jung. I propose here a new translation which makes Jung's meaning clearer, along with a commentary which explains it in the context of Freudian drive theory and German 19th century philosophy. Invoking the concepts of instinct, mind, and Eros (both the passion and the divine figure), Jung's theory says that male sexual desire can be cultivated or repressed in four distinct ways, each associated with a female symbolic figure or anima image: Eve, Helen, Mary and Sophia.

Dans son introduction à La Psychologie du Transfert (1946), Carl Jung esquisse une « phénoménologie érotique ¼ qui condense ses enseignements sur la sexualité et le désir en un résumé très concis. Mais le sens de ce passage est brouillé dans la traduction anglaise des Collected Works of C.G. Jung. Je propose ici une nouvelle traduction qui rend l'argument de Jung plus clair, suivie d'un commentaire qui l'explique dans le contexte de la théorie freudienne des pulsions et de la philosophie allemande du XIXe siècle. Invoquant les concepts d'instinct, d'esprit et d'Eros (en tant que passion ainsi que figure divine), la théorie de Jung dit que le désir sexuel masculin peut être cultivé ou réprimé de quatre manières distinctes, chacune associée à une figure symbolique féminine ou image de l'anima: Eve, Hélène, Marie et Sophia.

En la introducción a La Psicología de la Transferencia (1946), Carl Jung esbozó una "fenomenología erótica" que condensa sus enseñanzas sobre la sexualidad y el amor romántico en un resumen muy conciso. Pero el significado de este pasaje queda opacado en la traducción inglesa de las Obras Completas de C.G. Jung. Propongo aquí una nueva traducción que aclara el significado de Jung, junto con un comentario que lo explica en el contexto de la teoría freudiana de la pulsión y la filosofía alemana del siglo XIX. Invocando los conceptos de instinto, mente y Eros (tanto la pasión como la figura divina), la teoría de Jung expresa que el deseo sexual masculino puede cultivarse o reprimirse de cuatro maneras distintas, cada una asociada a una figura simbólica femenina o imagen del ánima: Eva, Helena, María y Sofía.

A time-series COVID-19 policy outcome analysis tool to measure human behavior from a herd instinct perspective.

Purpose: There are 47 municipalities and prefectures in Japan that operate similar COVID-19 policies in a unified manner. There are significant differences regarding their policy outcomes. In order to investigate when the outcomes are different, we made a COVID-19 policy outcome analysis tool, jpcovid for evaluating time-series scores of individual prefectures, not a policy analysis tool. Methods: Scoring policies is based on a single population mortality metric: the number of COVID-19 deaths divided by the population in millions from a demographic perspective. Results: Although uniformed policies have been adopted by the 47 prefectures in Japan, there are significant differences in the calculated scores among the 47 prefectures. This difference can be caused by differences in the herding instincts of the community with COVID-19 variants. The herd instinct is an inherent tendency to associate with others and follow the group's behavior or a behavior wherein people tend to react to the actions of others without considering the reason. The snapshot scoring tool, jpscore showed that Niigata has the best score of 67.9 while Osaka has the worst score of 727.9. jpcovid allows users to identify when herd instincts made changes in time-series scores. Conclusions: This is the world's first large-scale measurement on the herd instinct of prefectures in Japan. The proposed method can be applied to other countries in general. Supplementary Information: The online version contains supplementary material available at 10.1007/s12553-023-00759-x.

Combination of Rapid Intrinsic Activity Measurements and Machine Learning as a Screening Approach for Multicomponent Electrocatalysts.

Machine learning (ML) coupled with quantum chemistry calculations predicts catalyst properties with high accuracy; however, ML approaches in the design of multicomponent catalysts primarily rely on simulation data because obtaining sufficient experimental data in a short time is difficult. Herein, we developed a rapid screening strategy involving nanodroplet-mediated electrodeposition using a carbon nanocorn electrode as the support substrate that enables complete data collection for training artificial intelligence networks in one week. The inert support substrate ensures intrinsic activity measurement and operando characterization of the irreversible reconstruction of multinary alloy particles during the oxygen evolution reaction. Our approach works as a closed loop: catalyst synthesis-in situ measurement and characterization-database construction-ML analysis-catalyst design. Using artificial neural networks, the ML analysis revealed that the entropy values of multicomponent catalysts are proportional to their catalytic activity. The catalytic activities of high-entropy systems with different components varied little, and the overall catalytic activity was greater than that of the medium-low-entropy system. These findings will serve as a guideline for the design of catalysts.

How patients in general practice voice and value their gut feelings about health: a qualitative interview study.

BACKGROUND: GPs consider their gut feelings a valuable tool in clinical reasoning. Research suggests patients' gut feelings may be a useful contribution to that process. Describing these feelings more precisely could improve primary care professionals' (PCPs) recognition of patients' gut feelings and insight into the underlying reasons. These descriptions would also enable a thorough examination of the validity of patients' gut feelings and their contribution to professionals' clinical reasoning. AIM: To gather the words and phrases that patients or their relatives use to share their gut feelings with primary care professionals and what they convey and imply. DESIGN AND SETTING: Qualitative study of Dutch and Belgian patients visiting an out-of-hours GP service or a GP's office. METHOD: Face-to-face semi-structured interviews were carried out with 47 patients. Interviews were coded using a descriptive content analysis in an iterative process until data sufficiency. RESULTS: Patients or their relatives expressed their gut feelings by using words relating to trusting or not trusting the situation, or to changes in normal patterns. Their gut feelings are most often felt as a sense of alarm. In general, patients experiencing a sense of alarm, particularly mothers of sick children, were convinced that something was wrong and had often learned to trust their gut feeling. A gut feeling was the main reason to contact a PCP. Patients generally felt that their gut feelings were taken seriously. CONCLUSION: The findings of this study provide an insight into how patients and relatives may express their gut feelings about their own or their relative's health and how they share these feelings with healthcare professionals. This may help clinicians improve their recognition of patients' gut feelings, being particularly alert to a patient or relative using phrases that relate to feelings of not trusting a situation, things seeming wrong or different from normal, and experiencing a sense of alarm. Further research should be carried out into the validity of patients' gut feelings.

Variation in the rate of recovery in motor function between the upper and lower limbs in patients with stroke: some proposed hypotheses and their implications for research and practice.

Background: Stroke results in impairment of motor function of both the upper and lower limbs. However, although it is debatable, motor function of the lower limb is believed to recover faster than that of the upper limb. The aim of this paper is to propose some hypotheses to explain the reasons for that, and discuss their implications for research and practice. Method: We searched PubMED, Web of Science, Scopus, Embase and CENTRAL using the key words, stroke, cerebrovascular accident, upper extremity, lower extremity, and motor recovery for relevant literature. Result: The search generated a total of 2,551 hits. However, out of this number, 51 duplicates were removed. Following review of the relevant literature, we proposed four hypotheses: natural instinct for walking hypothesis, bipedal locomotion hypothesis, central pattern generators (CPGs) hypothesis and role of spasticity hypothesis on the subject matter. Conclusion: We opine that, what may eventually account for the difference, is the frequency of use of the affected limb or intensity of the rehabilitation intervention. This is because, from the above hypotheses, the lower limb seems to be used more frequently. When limbs are used frequently, this will result in use-dependent plasticity and eventual recovery. Thus, rehabilitation techniques that involve high repetitive tasks practice such as robotic rehabilitation, Wii gaming and constraint induced movement therapy should be used during upper limb rehabilitation.

Phenotypic plasticity and archetype: a response to common objections to the biological theory of archetype and instinct.

Since Jung's death in 1961, scholars have attempted to integrate growing biological science data into Jungian concepts such as the collective unconscious, instincts and the archetypes. This enterprise has been challenging due to persistent false dichotomies of gene and environment occasionally arising. Recent works by Roesler (2022a, 2022b) for example, have raised objections to the biological theory of archetypes, but the objections are plagued by such dichotomies. The concept of phenotypic plasticity, however, helps to both avoid this problem as well as bridge the gap between competing theories into a more integrated model with solid biological foundations.

Depuis la mort de Jung en 1961, les chercheurs ont tenté d'intégrer les données nouvelles de la biologie avec les concepts Jungiens tels que l'inconscient collectif, les instincts et les archétypes. Cette initiative a rencontré des difficultés car des dichotomies fausses mais tenaces sur le sujet des gènes et de l'environnement se manifestaient. Les travaux récents de Roesler (2022a, 2022b) par exemple ont exprimé des objections à la théorie biologique des archétypes. Cependant ces objections sont biaisées par les dichotomies mentionnées. Le concept de plasticité phénotypique, cependant, aide à la fois à éviter ce problème et à former une passerelle entre des théories rivales et un modèle mieux intégré et doté de solides fondements biologiques.

Desde la muerte de Jung en 1961, académicos han intentado integrar data creciente de las ciencias biológicas a conceptos Junguianos como inconsciente colectivo, instintos y arquetipos. Esta empresa ha sido desafiada debido al surgimiento ocasional de persistentes falsas dicotomías entre genes y medio ambiente. Trabajos recientes de Roesler (2022a, 2022b), por ejemplo, han planteado objeciones a la teoría biológica del arquetipo, pero las objeciones se encuentran afectadas por semejantes dicotomías. El concepto de plasticidad fenotípica, sin embargo, ayuda a evitar este problema, así como a subsanar la brecha entre teorías contrapuestas, hacia un modelo más integrado con fundamentos biógicos sólidos.