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1.
Transfusion ; 61(10): 2958-2968, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34272882

RESUMO

BACKGROUND: Babesia microti has gained a foothold in Canada as tick vectors become established in broader geographic areas. B. microti infection is associated with mild or no symptoms in healthy individuals but is transfusion-transmissible and can be fatal in immunocompromised individuals. This is the first estimate of clinically significant transfusion-transmitted babesiosis (TTB) risk in Canada. STUDY DESIGN AND METHODS: The proportion of B. microti-antibody (AB)/nucleic acid amplification test (NAT)-positive whole blood donations was estimated at 5.5% of the proportion of the general population with reported Lyme Disease (also tick-borne) based on US data. Monte Carlo simulation estimated the number and proportion of infectious red cell units for three scenarios: base, localized incidence (risk in Manitoba only), and donor study informed (prevalence from donor data). The model simulated 1,029,800 donations repeated 100,000 times for each. RESULTS: In the base scenario 0.5 (0.01, 1.75), B. microti-NAT-positive donations would be expected per year, with 0.08 (0, 0.38) recipients suffering clinically significant TTB (1 every 12.5 years). In the localized incidence scenario, there were 0.21(0, 0.7) B. microti-NAT-positive donations, with 0.04 (0, 0.14) recipient infections (about 1 every 25 years). In the donor study informed scenario, there were 4.6 (0.3, 15.8) B. microti-NAT-positive donations expected, and 0.81 (0.05, 3.14) clinically significant TTB cases per year. DISCUSSION: The likelihood of clinically relevant TTB is low. Testing would have very little utility in Canada at this time. Ongoing pathogen surveillance in tick vectors is important as B. microti prevalence appears to be slowly increasing in Canada.


Assuntos
Babesia microti/isolamento & purificação , Babesiose/etiologia , Reação Transfusional/etiologia , Babesiose/parasitologia , Babesiose/transmissão , Doadores de Sangue , Transfusão de Sangue , Canadá/epidemiologia , Humanos , Método de Monte Carlo , Fatores de Risco , Reação Transfusional/parasitologia
2.
Transfus Apher Sci ; 59(5): 102843, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32616365

RESUMO

BACKGROUND: Transfusion transmitted babesiosis (TTB) has a high mortality rate but may go unrecognized, particularly in non-endemic areas. We therefore conducted a systematic review to better characterize clinical aspects of TTB. METHODS: A literature search was conducted in PubMed and CINAHL databases, from which 25 eligible articles describing 60 TTB patients met criteria for data extraction. RESULTS: Symptom evaluation was provided for 25 implicated donors: 18/25 (72%) were asymptomatic while 7/25 (28%) had mild flu-like symptoms but were asymptomatic at time of donation. It was common for a single donor or donation to infect multiple patients. Where reported, species included B. microti - 54/60 (90%), B. duncani - 3/60 (5%), and B. divergens-like/MO-1 - 1/60 (2%). Most TTB patients (44/60, 73%) resided in endemic states, while most TTB deaths 6/9 (67%) occurred in non-endemic states. Severity of hemolysis was proportional to degree of parasitemia. Mortality in our series was 9/60 (15%); most deaths occurred at extremes of the age spectrum: 6/9 non-survivors were aged >55 years, 2/9 were <1 year, only 1/9 was 2-54 years. Number of comorbidities was higher among non-survivors (median = 4) compared to survivors (median = 1). CONCLUSIONS: All implicated donors (for which symptoms data were reported) resulting in TTB infections were asymptomatic at the time of donation, and it was common for a single donor or donation to infect multiple patients. Mortality of TTB appeared highest among those with more comorbidities and in non-endemic states. Heightened awareness of this diagnosis is key in its recognition.


Assuntos
Babesiose/etiologia , Reação Transfusional/complicações , Babesiose/mortalidade , Babesiose/fisiopatologia , Feminino , Humanos , Masculino , Análise de Sobrevida
3.
Transfus Apher Sci ; 59(6): 102902, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32798133

RESUMO

Babesiosis, a novel zoonosis, is endemic in the Northeast and Midwest United States. This disease is primarily transmitted by ticks and less commonly transmitted through blood transfusion. Here, we present a case of human babesiosis of unknown etiology. The patient may have been infected through blood transfusion. This patient had fever for more than 1 month, accompanied by fatigue, anemia, jaundice, and other symptoms. Clinical improvement was unsatisfactory with antibiotics. Subsequently, peripheral blood smears showed many circulating forms of parasites,morphologically consistent with Babesia in red blood cells. Gene sequencing suggested Babesia microti. We treated the patient with azithromycin combined with other symptomatic supportive treatment. Finally, the patient recovered and was discharged. The intensity of babesiosis ranges from mild to severe and can be fatal, so early diagnosis and treatment are warranted.


Assuntos
Babesiose/etiologia , Reação Transfusional/complicações , Adulto , Babesiose/patologia , China , Humanos , Masculino , Estados Unidos
4.
Clin Transplant ; 33(9): e13546, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-30900295

RESUMO

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of tissue and blood protozoal infections in the pre- and post-transplant period. Significant new developments in the field have made it necessary to divide the previous single guideline published in 2013 into two sections, with the intestinal parasites separated from this guideline devoted to tissue and blood protozoa. The current update reflects the increased focus on donor screening and risk-based recipient monitoring for parasitic infections. Increased donor testing has led to new recommendations for recipient management of Toxoplasma gondii and Trypanosoma cruzi. Molecular diagnostics have impacted the field, with access to rapid diagnostic testing for malaria and polymerase chain reaction testing for Leishmania. Changes in Babesia treatment regimens in the immunocompromised host are outlined. The risk of donor transmission of free-living amebae infection is reviewed. Changing immigration patterns and the expansion of transplant medicine in developing countries has contributed to the recognition of parasitic infections as an important threat to transplant outcomes. Medications such as benznidazole and miltefosine are now available to US prescribers as access to treatment of tissue and blood protozoa is increasingly prioritized.


Assuntos
Antiprotozoários/uso terapêutico , Transplante de Órgãos/efeitos adversos , Guias de Prática Clínica como Assunto/normas , Infecções por Protozoários/diagnóstico , Infecções por Protozoários/tratamento farmacológico , Acanthamoeba/isolamento & purificação , Amebíase/diagnóstico , Amebíase/tratamento farmacológico , Amebíase/etiologia , Babesia/isolamento & purificação , Babesiose/diagnóstico , Babesiose/tratamento farmacológico , Babesiose/etiologia , Infecções Protozoárias do Sistema Nervoso Central/diagnóstico , Infecções Protozoárias do Sistema Nervoso Central/tratamento farmacológico , Infecções Protozoárias do Sistema Nervoso Central/etiologia , Doença de Chagas/diagnóstico , Doença de Chagas/tratamento farmacológico , Doença de Chagas/etiologia , Humanos , Leishmania/isolamento & purificação , Leishmaniose/diagnóstico , Leishmaniose/tratamento farmacológico , Leishmaniose/etiologia , Naegleria/isolamento & purificação , Infecções por Protozoários/etiologia , Sociedades Médicas , Toxoplasma/isolamento & purificação , Toxoplasmose/diagnóstico , Toxoplasmose/tratamento farmacológico , Toxoplasmose/etiologia , Transplantados , Trypanosoma cruzi/isolamento & purificação
5.
Transfus Apher Sci ; 58(5): 638-640, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31526674

RESUMO

We report a case of severe babesiosis presenting with 43% parasitemia in a 73-year-old splenectomized woman on etanercept for rheumatoid arthritis. She initially was treated aggressively with clindamycin and quinine and exchange transfusion. Despite a post-exchange drop in parasitemia to 7.6%, it rebounded to 11.4% on hospital day 5 accompanied by new onset high fevers and hypoxia. She improved after a second exchange transfusion and ultimately resolved her infection after 12 weeks of antibabesial antibiotics. Although exchange transfusion is commonly used in immunocompromised hosts, there is a dearth of information about repeat exchange transfusion, including the risk for and outcome of repeat exchange. We performed a literature search for other cases of repeat exchange transfusion for severe Babesia microti infection and compared our case with those in other published reports.


Assuntos
Babesia microti , Babesiose/terapia , Clindamicina/administração & dosagem , Transfusão Total , Quinina/administração & dosagem , Idoso , Artrite Reumatoide/terapia , Babesiose/etiologia , Etanercepte/administração & dosagem , Etanercepte/efeitos adversos , Feminino , Humanos , Parasitemia/etiologia , Parasitemia/terapia , Esplenectomia
6.
Transpl Infect Dis ; 19(5)2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28636757

RESUMO

We report a unique case of babesiosis presenting as sepsis after kidney transplantation. A 70-year-old female kidney transplant recipient presented with fever, hemolytic anemia, and acute kidney injury, and met three of four systemic inflammatory response syndrome criteria. Serology was positive for Babesia microti, confirmed by polymerase chain reaction. The patient was treated with atovaquone and azithromycin and made a full recovery. Reports of babesiosis after solid organ transplantation are rare, with only four prior cases reported in the literature. We report the first case of babesiosis, to our knowledge, presenting as sepsis that was successfully treated after solid organ transplantation.


Assuntos
Babesiose/sangue , Transplante de Rim , Sepse/sangue , Idoso , Babesia microti/isolamento & purificação , Babesiose/etiologia , Babesiose/microbiologia , Feminino , Humanos
8.
Bull Math Biol ; 77(3): 514-47, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25715822

RESUMO

Bovine Babesiosis in cattle is caused by the transmission of protozoa of Babesia spp. by ticks as vectors. Juvenile cattle (<9 months of age) have resistance to Bovine Babesiosis, rarely show symptoms, and acquire immunity upon recovery. Susceptibility to the disease varies between breeds of cattle. Models of the dynamics of Bovine Babesiosis transmitted by the cattle tick that include these factors are formulated as systems of ordinary differential equations. Basic reproduction numbers are calculated, and it is proved that if these numbers are below the threshold value of one, then Bovine Babesiosis dies out. However, above the threshold number of one, the disease may approach an endemic state. In this case, control measures are suggested by determining target reproduction numbers. The percentage of a particular population (for example, the adult bovine population) needed to be controlled to eradicate the disease is evaluated numerically using Columbia data from the literature.


Assuntos
Babesiose/etiologia , Doenças dos Bovinos/etiologia , Modelos Biológicos , Animais , Babesiose/prevenção & controle , Babesiose/transmissão , Número Básico de Reprodução , Bovinos , Doenças dos Bovinos/prevenção & controle , Doenças dos Bovinos/transmissão , Conceitos Matemáticos
10.
Transfusion ; 54(7): 1725-32, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24673158

RESUMO

BACKGROUND: After malaria, babesiosis is the second most common transfusion-transmitted parasitic disease in the United States. In Europe, one reported transfusion case, concerning Babesia microti, occurred in Germany. STUDY DESIGN AND METHODS: Due to the fact that Babesia spp. are present in Tyrolean ticks, the aim of this study is to assess the occurrence of immunoglobulin (Ig)G antibodies against the Babesia divergens complex, including B. divergens and Babesia venatorum (EU1), as well as B. microti by screening a representative collective of 988 blood donors from North and East Tyrol (Austria) with indirect immunofluorescence antibody test. Additionally, we investigated 206 local ixodid ticks for the presence of babesial DNA by polymerase chain reaction. RESULTS: Seroprevalence data resulted in rates of 2.1% for IgG antibodies against the B. divergens complex and 0.6% against B. microti in Tyrolean blood donors. All sera could be confirmed by independent retesting. Our data indicate that cross-reactivity is high between B. divergens and B. venatorum and lower than 19.8% between B. divergens and B. microti. CONCLUSIONS: This study shows that Babesia spp. are present in the Tyrols, which blood donors come into serologic contact with, and that we have to consider how to sustain blood product safety concerning this new challenge. Additionally, it is the first description of B. venatorum in the Tyrols, found in one Ixodes ricinus at the Italian border.


Assuntos
Babesia/isolamento & purificação , Babesiose/epidemiologia , Babesiose/etiologia , Reação Transfusional , Adolescente , Adulto , Idoso , Áustria/epidemiologia , Babesia/genética , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Medição de Risco , Estudos Soroepidemiológicos , Adulto Jovem
12.
Am Surg ; 77(3): 345-7, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21375849

RESUMO

Babesiosis is an emerging infection most commonly acquired from a tick bite. We describe three hospitalized patients with fever attributable to babesiosis after a splenectomy. Splenectomy was done because of splenic enlargement due to unsuspected babesia infection in one patient and because of splenic perforation due to babesiosis in a second patient. The third patient underwent splenectomy for trauma and acquired babesiosis postoperatively from a blood transfusion. Our cases demonstrate the need to be vigilant for babesiosis in patients undergoing splenectomy.


Assuntos
Babesiose/diagnóstico , Febre/parasitologia , Esplenectomia/efeitos adversos , Esplenopatias/parasitologia , Esplenopatias/cirurgia , Reação Transfusional , Babesiose/etiologia , Babesiose/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Esplenopatias/diagnóstico , Adulto Jovem
13.
Emerg Infect Dis ; 16(7): 1116-8, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20587183

RESUMO

We report an unusual case of human babesiosis in Finland in a 53-year-old man with no history of splenectomy. He had a rudimentary spleen, coexisting Lyme borreliosis, exceptional dark streaks on his extremities, and subsequent disseminated aspergillosis. He was infected with Babesia divergens, which usually causes bovine babesiosis in Finland.


Assuntos
Babesiose/etiologia , Evolução Fatal , Finlândia , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo
14.
J Clin Apher ; 25(6): 358-61, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20824620

RESUMO

Transfusion-acquired babesiosis can be an asymptomatic or self-limited febrile hemolytic illness in a healthy host. A persistent, relapsing, and/or fulminant course with the development of life-threatening complications may be seen in immunocompromised or splenectomized patients. As in malaria, erythrocyte parasitemia is often associated with nonimmune hemolysis, and can be treated with erythrocytapheresis. Just as warm autoantibodies have been reported in malaria infection, the development of autoantibody-mediated immune hemolysis has been reported in babesiosis. We treated a previously healthy male with multiple injuries from a motor vehicle accident necessitating massive transfusion. Late in the hospitalization, his blood smear revealed Babesia microti, confirmed by PCR study and serology. This was eventually traced to a unit of blood from an asymptomatic blood donor that was transfused during his initial trauma care. Specific antibiotic therapy was begun, and severe hemolysis from a high parasite burden required red blood cell exchange which led to rapid abatement of the hemolysis. He had a positive DAT (IgG with a pan-reactive eluate) but no serum autoantibody. This persisted for 10 days following cessation of hemolysis, and became negative while still on antibiotics while his parasite burden became undetectable. Reports of autoimmunity associated with community acquired babesiosis often have severe hemolysis from their autoantibodies, but our case shows that autoantibodies may also follow transfusion-acquired babesiosis. The nature of the autoantigen is unknown.


Assuntos
Autoimunidade , Babesiose/imunologia , Reação Transfusional , Babesiose/diagnóstico , Babesiose/etiologia , Humanos , Masculino , Pessoa de Meia-Idade
15.
Clin Infect Dis ; 48(1): 25-30, 2009 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-19035776

RESUMO

BACKGROUND: Human babesiosis is an illness with clinical manifestations that range from asymptomatic to fatal. Although babesiosis is not nationally notifiable, the US incidence appears to be increasing. Babesia infection is a transfusion-transmissable disease. An estimated 70 cases were reported during 1979-2007; most of these cases were reported during the past decade. METHODS: We queried the 3 following US Food and Drug Administration safety surveillance systems to assess trends in babesiosis reporting since 1997: fatality reports for blood donors and transfusion recipients, the Adverse Event Reporting System (which includes MedWatch), and the Biological Product Deviations Reporting system.We analyzed fatality reports for time frames, clinical presentations, and patient and donor demographic characteristics. RESULTS: Eight of 9 deaths due to transfusion-transmitted babesiosis that were reported since 1997 occurred within the past 3 years (2005-2007). Four implicated donors and 5 patients lived in areas where Babesia infection is not endemic. Increasing numbers of Biological Product Deviations Reports were submitted to the US Food and Drug Administration over the past decade; the Adverse Event Reporting System received no reports. CONCLUSIONS: After nearly a decade with no reported death due to transfusion-transmitted babesiosis, the US Food and Drug Administration received 8 reports from November 2005 onward. The increased numbers of deaths reported and Biological Product Deviations Reports suggest an increasing incidence of transfusion-transmitted babesiosis. Physicians should consider babesiosis in the differential diagnosis in immunocompromised, febrile patients with a history of recent transfusion, even in areas where Babesia infection is not endemic. Accurate and timely reporting of babesiosis-related donor and transfusion events assists the US Food and Drug Administration in developing appropriate public health-control measures.


Assuntos
Babesiose/epidemiologia , Babesiose/etiologia , Reação Transfusional , Adulto , Idoso , Idoso de 80 Anos ou mais , Babesiose/mortalidade , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estados Unidos , United States Food and Drug Administration
16.
Transfus Med Rev ; 33(2): 84-91, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30930009

RESUMO

Transfusion-transmitted infections (TTIs) can be severe and result in death. Transfusion-transmitted viral pathogen transmission has been substantially reduced, whereas sepsis due to bacterial contamination of platelets and transfusion-transmitted babesiosis may occur more frequently. Quantifying the burden of TTI is important to develop targeted interventions. From January 1, 2010, to December 31, 2016, health care facilities participating in the National Healthcare Safety Network Hemovigilance Module monitored transfusion recipients for evidence of TTI and recorded the total number of units transfused. Facilities use standard criteria to report TTIs. Incidence rates of TTIs, including for bacterial contamination of platelets and transfusion-transmitted babesiosis, are presented. One hundred ninety-five facilities reported 111 TTIs and 7.9 million transfused components to the National Healthcare Safety Network Hemovigilance Module. Of these 111 reports, 54 met inclusion criteria. The most frequently reported pathogens were Babesia spp in RBCs (16/23, 70%) and Staphylococcus aureus in platelets (12/30, 40%). There were 1.95 (26 apheresis, 4 whole blood derived) TTIs per 100 000 transfused platelet units and 0.53 TTI per 100 000 transfused RBC components, compared to 0.68 TTI per 100 000 all transfused components. Bacterial contamination of platelets and transfusion-transmitted babesiosis were the most frequently reported TTIs. Interventions that reduce the burden of bacterial contamination of platelets, particularly collected by apheresis, and Babesia transmission through RBC transfusion would reduce transfusion recipient morbidity and mortality. These analyses demonstrate the value and importance of facility participation in national recipient hemovigilance using standard reporting criteria.


Assuntos
Babesiose/epidemiologia , Segurança do Sangue/normas , Transfusão de Sangue , Reação Transfusional/epidemiologia , Babesia , Babesiose/etiologia , Bancos de Sangue/normas , Remoção de Componentes Sanguíneos/efeitos adversos , Transfusão de Componentes Sanguíneos/efeitos adversos , Humanos , Transfusão de Plaquetas/efeitos adversos , Infecções Estafilocócicas/epidemiologia , Infecções Estafilocócicas/etiologia , Staphylococcus aureus , Reação Transfusional/etiologia , Estados Unidos
17.
J Parasitol ; 105(4): 491-496, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31268412

RESUMO

Canine babesiosis (CB) is a significant tick-borne disease caused by intra-erytrocytic protozoa of the genus Babesia (Apicomplexa: Piroplasmida) and is currently emerging or re-emerging in many European countries. Despite the increasing incidence of clinical CB, little is known of the epidemiology of this disease in Romania. Therefore, the present study was conducted to provide epidemiological data on CB in the coastal area of the Black Sea (Dobrogea), southeastern Romania. For this, 306 owned dogs presented during 2016-2018 at a veterinary clinic in the area and clinically suspected for CB were tested for the presence of intra-erytrocytic piroplasms using Giemsa-stained thin blood smears. Overall, 27.8% (95% CI: 22.83-33.16) of dogs were positive for large piroplasms. The Babesia spp.-positive dogs were 51 males and 34 females aged from 3 mo to 13 yr (mean 4.2 yr; SD = 3.6). A higher rate of infection was registered in Bichon Maltese (n = 13) and mixed-breed (n = 28) dogs. Most cases (76/85; 89.4%) were diagnosed from March to June, with only a few cases registered in November and December (1 case each). Infected dogs displayed different clinical presentations, varying from mild (38.8%) to moderate (29.4%) and severe disease (29.4%). Based on clinical- pathological changes, 38 (44.7%), 34 (40.0%), and 13 (15.3%) dogs were diagnosed with uncomplicated babesiosis, complicated babesiosis with a single organ dysfunction, and complicated babesiosis with multiple-organ-dysfunction syndrome (MODS), respectively. The recovery rate (81.6%, 70.1%, and 38.4%, respectively) was significantly different in these groups. The age of dogs appeared to be a risk factor for both severe disease (mean age of 5.8 yr) and MODS (mean age 6.8 yr). These findings document the common occurrence of CB in Dobrogea, southeastern Romania, and suggest that appropriate control measures need to be taken.


Assuntos
Babesiose/epidemiologia , Doenças do Cão/epidemiologia , Doenças do Cão/parasitologia , Distribuição por Idade , Fatores Etários , Animais , Antiprotozoários/uso terapêutico , Babesia/isolamento & purificação , Babesiose/tratamento farmacológico , Babesiose/etiologia , Babesiose/parasitologia , Mar Negro/epidemiologia , Doenças do Cão/tratamento farmacológico , Doenças do Cão/mortalidade , Cães , Eritrócitos/parasitologia , Feminino , Imidocarbo/análogos & derivados , Imidocarbo/uso terapêutico , Masculino , Fatores de Risco , Romênia/epidemiologia , Estações do Ano , Distribuição por Sexo , Infestações por Carrapato/complicações , Infestações por Carrapato/epidemiologia , Infestações por Carrapato/veterinária
18.
Surg Clin North Am ; 98(1): 87-94, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29191280

RESUMO

Complications after pancreaticoduodenal resection occur in at least 30% of patients. Most are a direct result of an intraoperative event, dissection, or anastomoses which account for the most serious morbidities, sepsis, pseudoaneurysms, and hemorrhage. Rarely, complications are due to the systemic impact of the procedure even if the procedure itself was unremarkable. Rare systemic complications after PDR (Transfusion transmitted Babesiosis, pituitary apoplexy, and TRALI) and a number of uncommon and unusual other complications are discussed. Pancreaticoduodenal resection is a significant operation with serious consequences. Decisions on selection of candidates and safe operations should be thoughtful and always in surgeons' minds.


Assuntos
Lesão Pulmonar Aguda/etiologia , Babesiose/etiologia , Neoplasias Pancreáticas/cirurgia , Pancreaticoduodenectomia/efeitos adversos , Apoplexia Hipofisária/etiologia , Complicações Pós-Operatórias/etiologia , Doenças Raras , Transfusão de Sangue , Humanos
19.
Mil Med ; 170(4): 295-6, 2005 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15916297

RESUMO

Babesiosis is a tick-borne illness endemic to the coastal areas of southern New England. Despite the enormous safety measures that transfusion and blood bank services perform for each product, transfusion of blood products is not without risk. The majority of transfusion-related reactions and complications are recognized soon after transfusion. We report a case of transfusion-acquired babesiosis in Washington State that presented 4 weeks after transfusion of a blood product from a donor living in a babesiosis-endemic area.


Assuntos
Babesiose/etiologia , Reação Transfusional , Idoso , Humanos , Masculino , Doadores de Tecidos
20.
Int J Infect Dis ; 33: 202-4, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25686807

RESUMO

Human babesiosis is a zoonosis primarily transmitted through Ixodes ticks and alternatively by routes such as blood transfusions from asymptomatic donors. We report the first case of human babesiosis caused by Babesia divergens in a patient with HIV. This study also focuses on elucidating the possible transmission route of infection in this patient, who received numerous blood transfusions but showed patent symptoms only after splenectomy. A battery of detection tools along with a novel Western-Blot Assay and Enzyme Linked Immunosorbent Assay using the major surface protein of B. divergens (Bd37) as a target were used to evaluate the presence of B. divergens or antibodies against the parasite in samples from the patient and the blood donors involved in this case. A retrospective study of the humoral status against the parasite revealed B. divergens IgG antibodies in one of the implicated donors, but also showed that the patient had been already exposed to the parasite before any transfusion. Thus, this analysis of natural and transfusion transmission routes suggests a pre-existing subclinical babesiosis in the patient.


Assuntos
Babesia/isolamento & purificação , Babesiose/diagnóstico , Coinfecção/diagnóstico , Infecções por HIV/complicações , Adulto , Babesiose/etiologia , Doadores de Sangue , Transfusão de Sangue , Humanos , Masculino , Estudos Retrospectivos , Esplenectomia
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