Mechanisms underlying the adaptive pulp and jaw bone trabecular changes in sickle cell anemia.

OBJECTIVE: Mechanisms underlying the oral outcomes in sickle cell anemia (HbSS) have been less explored. This study aimed to investigate the association of morbimortality indicators and hydroxyurea use with adaptive pulp and jaw bone trabecular changes in HbSS. METHODS: This cross-sectional study included 123 individuals with HbSS. The exposures were the morbimortality indicators of HbSS (number of vaso-occlusive crises, organ damage, hemoglobin level, and leukocyte count) and the use of hydroxyurea for HbSS treatment. The outcomes were adaptive pulp and jaw bone trabecular changes confirmed by radiographic examination. Associations were estimated by Poisson regression in crude and adjusted analyses for sex, skin color, socioeconomic class, and age. RESULTS: The vaso-occlusive crises (mean ratio (MR) = 3.5, p = 0.045), lower hemoglobin (MR = 2.4, p = 0.037), and higher leukocyte count (MR = 2.17, p = 0.036) were risk factors, while the use of hydroxyurea was inversely associated with adaptive pulp changes (MR = 0.23, p = 0.024). The vaso-occlusive crises were associated with jaw bone trabecular changes (MR = 1.33, p = 0.02). CONCLUSION: Adaptive pulp changes may be a potential clinical marker of chronic vasculopathy in HbSS. The use of hydroxyurea may reduce the frequency of adaptive pulp changes.

Idiopathic Radiographic Apical Root Resorption in Wind Instrument Players.

Root resorption of the permanent teeth involves an elaborate interaction among inflammatory cells resulting in loss of dental hard tissues. This report describes three clinical cases where idiopathic root resorption occurred in wind instrument playing patients. These patients produce adequate non-orthodontic forces, while playing their instruments, to expose their teeth to root resorbing force. Careful clinical monitoring of patients' teeth should be undertaken, as the additive effects of orthodontic treatment and musical habits are unknown. CPD/Clinical Relevance: This paper advises that questioning about wind instrument playing during case history-taking would be beneficial to clinicians. Furthermore, careful clinical monitoring of these patients' teeth during orthodontic treatment should be undertaken.

Dental pulp therapy for primary teeth in children undergoing cancer therapy.

BACKGROUND: Childhood cancer treatment negatively affects the immune system, increasing the risk for bacteremia and septicemia. As the oral cavity is a major entry portal for pathogens into the bloodstream dental care in such children tends to be radical, favouring tooth extraction over less drastic treatments such as pulpotomy, the amputation of infected dental pulp. The present study aimed to compare pulpotomy treatment success rate in children with cancer receiving immunosuppressive therapy with that of healthy children, and investigate if unsuccessful pulpotomy treatment in oncologic patients may lead to systemic complications. PROCEDURE: Twenty-six medical records of children from a paediatric oncology referral centre who had dental pulpotomy treatment (in 41 teeth) while receiving active cancer care during the years 2006-2012 were compared with records of 41 randomly selected healthy children who had undergone pulpotomy treatment (41 teeth) in the same institute during these years. Clinical and radiographic data were collected during treatments and at the end of the follow-up period (six months post dental treatment). RESULTS: No statisticaly significant difference was found between pulpotomy success rate amongst the two groups. Treatments success rates in the study and control groups were 82.9% (± 5.9) and 90.2% (± 4.7), respectively. No patient in the study group suffered from sepsis from a dental origin during follow-up period. CONCLUSIONS: Pulpotomy in paediatric cancer patients did not increase the risk for bacteremia or systemic complications from oral origin. We therefore recommend the re-evaluation of the current protocol for treating paediatric oncology patients.

Radiological diagnosis of periapical bone tissue lesions in endodontics: a systematic review.

This systematic review evaluates the diagnostic accuracy of radiographic methods employed to indicate presence/absence and changes over time of periapical bone lesions. Also investigated were the leads radiographic images may give about the nature of the process and the condition of the pulp in nonendodontically treated teeth. Electronic literature search included the databases PubMed, Embase and CENTRAL from January 1950 to June 2011. All languages were accepted provided there was an abstract in English. The MeSH terms were 'Cone beam computed tomography (CBCT)', 'Radiography, panoramic', 'Periapical diseases', 'Dental pulp diseases', 'Sensitivity and specificity', 'receiver operating characteristics (ROC) curve', 'Cadaver', 'Endodontics' and 'Radiography dental'. Two reviewers independently assessed abstracts and full text articles. An article was read in full text if at least one of the two reviewers considered an abstract to be potentially relevant. Altogether, 181 articles were read in full text. The GRADE approach was used to assess the quality of evidence of each radiographic method based on studies of high or moderate quality. Twenty-six studies fulfilled criteria set for inclusion. None was of high quality; 11 were of moderate quality. There is insufficient evidence that the digital intraoral radiographic technique is diagnostically as accurate as the conventional film technique. The same applies to CBCT. No conclusions can be drawn regarding the accuracy of radiological examination in identifying various forms of periapical bone tissue changes or about the pulpal condition.

The detection of periapical pathosis using periapical radiography and cone beam computed tomography - part 1: pre-operative status.

AIM: Part 1 of this 2 part study aims to compare the prevalence of periapical lesions on individual roots viewed with intraoral (periapical) radiographs and cone-beam computed tomography (CBCT) of teeth treatment planned for endodontic treatment. METHODOLOGY: Diagnostic periapical radiographs and CBCT scans were taken of 151 teeth in 132 patients diagnosed with primary endodontic disease. The presence or absence of periapical lesions was assessed by a consensus panel consisting of two calibrated examiners, a consensus agreement was reached if there was any disagreement. The panel viewed the images under standardised conditions. Part 2 will compare the radiographic outcome 1 year after completion of primary root canal treatment. RESULTS: Two hundred and seventy-three paired roots were assessed with both radiological systems, periapical lesions were present in 55 (20%) and absent in 218 (80%) roots assessed with periapical radiographs. When the same 273 sets of roots were assessed with CBCT, lesions were present in 130 (48%) and absent in 143 (52%) roots. Seventy-five additional roots were detected with CBCT. CONCLUSION: The limitations of periapical radiographs which may hinder the detection of periapical lesions are overcome with CBCT. This results in firstly, more roots being assessed, and secondly, more periapical lesions being detected with CBCT.

A review of the questions and needs in endodontic diagnosis.

The current diversity of opinions in endodontic diagnosis has been a source of interest and academic debate by clinicians and researchers. Currently, no single pulp testing technique can reliably diagnose all pulpal conditions neither it has been proven to be superior in all aspects. Despite improvements of various aspects of this process, there are no historically dramatic changes, or consensus for pulpal status in health or disease in addition to a lack of relative systematic reviews. In this review, the past, present and future most debated and critically questioned issues of endodontic diagnosis are discussed. The aim of this review is to provide insights in future diagnostic modalities and areas for further study in endodontic practice pertinent to diagnosis.

Pulp pathosis in inlayed teeth of the ancient Mayas: a microcomputed tomography study.

AIM: To evaluate three-dimensionally, using microcomputed tomography (µCT), the anatomical relationship between the cavity prepared to hold the inlay stone and the pulp chamber in the teeth of the ancient Maya. METHODOLOGY: Six well-preserved teeth from Maya corpses found in an archaeological site in Guatemala (approximately 1600 year old) were selected and scanned using a high-resolution µCT system (SkyScan 1174v2; SkyScan N.V., Kontich, Belgium). The sample comprised six maxillary teeth: two canines, one premolar, two central incisors and one lateral incisor. All teeth had one or two inlay stones on the buccal surface of the crown. Each specimen was scanned at an isotropic resolution of 22.5 µm, a rotational step of 0.70°, a rotational angle of 180° and a 3.1-s exposure time, using a 1-mm-thick aluminium filter. Images of each specimen were reconstructed from apex to the crown with dedicated software (NRecon v1.6.1.5) in approximately 450 slices. CTan v1.11 and CTVol v2.1 were used for three-dimensional visualization and qualitative analysis of the external and internal anatomy of the teeth. RESULTS: The tooth modification in all samples was classified as type E1 (one stone on the buccal surface of the crown) or E2 (two stones on the buccal surface of the crown). In the canine teeth, the cavities created to insert the inlay stone did not reach the pulp chamber. Conversely, in the maxillary incisors, the cavities clearly perforated the pulp chamber resulting in massive internal inflammatory resorption or partial calcification of the pulp cavity. In the premolar tooth, a small perforation of the pulp chamber under the buccal cusp, without morphological alteration of the intraradicular dentine, was observed. CONCLUSIONS: Microcomputed tomography analysis of teeth of the ancient Maya civilization showed that the inlay cavities cut reached the pulp chamber in the maxillary incisors and premolar teeth, with the potential to cause pulp and periapical disease.

CBCT technology: endodontics and beyond, Part 2.

There is a saying that knowledge is power. Without realizing it, 2-D imaging has created a large information gap due to its limitations as a technology resource. As dental professionals, we have relied on this technology while rarely questioning its validity or the quality of information it provided to us. With the advent of 3-D imaging, that information gap has been narrowed. CBCT imaging has stretched our boundaries, allowing for complete and accurate information in all 3 dimensions. This new knowledge is a most powerful force in dentistry that will dynamically change our ideas, diagnoses, and treatment options. It is the author's belief that the implementation of this technology will lead to new innovations and better care in all specialties of dentistry.

AAE and AAOMR joint position statement. Use of cone-beam-computed tomography in endodontics.

All radiographic examinations must be justified on an individual needs basis whereby the benefits to the patient of each exposure must outweigh the risks. In no case may the exposure of patients to X-rays be considered "routine", and certainly CBCT examinations should not be done without initially obtaining a thorough medical history and clinical examination. CBCT should be considered an adjunct to two-dimensional imaging in dentistry. Limited field of view CBCT systems can provide images of several teeth from approximately the same radiation dose as two periapical radiographs, and they may provide a dose savings over multiple traditional images in complex cases.

Cone beam computed tomography (CBCT) in endodontics.

UNLABELLED: Cone beam computed tomography (CBCT) is an extra-oral imaging system which produces 3-dimensional scans of the maxillofacial skeleton. It is useful in overcoming the limitations of conventional radiography. CBCT is a valuable aid in providing additional information for diagnosis and enabling more predictable management of complex endodontic problems compared to using intra-oral radiographs alone. CLINICAL RELEVANCE: There are potential indications for the use of CBCT in diagnosis and treatment planning.

Cone-beam CT diagnostic applications: caries, periodontal bone assessment, and endodontic applications.

Cone-beam CT (CBCT) is useful for many maxillofacial applications, such as implant site imaging and diagnosis and treatment planning for orthodontics and craniofacial surgery. Dentoalveolar applications, such as carious lesion detection and characterization, assessment of the three-dimensional nature of periodontal bone topography, and various endodontic applications are less known and not as thoroughly studied. This article explores and assesses in vivo and in vitro efforts to apply CBCT imaging to these more common dentoalveolar tasks. CBCT imaging, like its medical counterpart, can be seen as a highly useful and, in some instances, indispensable part of the dental imaging armamentarium.

[Role of the operating microscope in diagnosis and treatment of endodontic diseases].

The excellent magnification and illumination of the operating microscope not only helps to improve the quality of conventional root canal therapy, but also plays an important role in the diagnosis and treatment of the difficult cases of endodontic diseases. It has an irreplaceable position over other equipment especially for the treatment of root canal therapy complications and the apical surgery. The structure and operation of the operating microscope are relatively complicated. The proficiency of the dentist may influence the evaluation of its clinical application effect. Based on the review of literature and author's clinical experience, this paper evaluates the role of operating microscope in the diagnosis and treatment of endodontic diseases.

A clinicoradiographic comparison of the effects of platelet-rich fibrin gel and platelet-rich fibrin membrane as scaffolds in the apexification treatment of young permanent teeth.

AIMS: This triple blinded clinical trial was undertaken to check whether Platelet rich firin in its membrane form is as reliable as when it is in the gel form. SETTINGS AND DESIGN: Triple blinded randomized clinical trial. METHODS AND MATERIAL: 20 patients in PRF gel group and 20 patients in PRF membrane group selected after randomization and considering inclusion and exclusion criteria were taken up for this study. The samples were clinically and radiographically evaluated for success. RESULTS AND CONCLUSIONS: Regenerative endodontics with PRF membrane is easier and less time consuming. They have similar clinical success.PRF gel gave a better radiographic success in 12 months period.

Root perforations: a review of diagnosis, prognosis and materials.

Root perforation results in the communication between root canal walls and periodontal space (external tooth surface). It is commonly caused by an operative procedural accident or pathological alteration (such as extensive dental caries, and external or internal inflammatory root resorption). Different factors may predispose to this communication, such as the presence of pulp stones, calcification, resorptions, tooth malposition (unusual inclination in the arch, tipping or rotation), an extra-coronal restoration or intracanal posts. The diagnosis of dental pulp and/or periapical tissue previous to root perforation is an important predictor of prognosis (including such issues as clinically healthy pulp, inflamed or infected pulp, primary or secondary infection, and presence or absence of intracanal post). Clinical and imaging exams are necessary to identify root perforation. Cone-beam computed tomography constitutes an important resource for the diagnosis and prognosis of this clinical condition. Clinical factors influencing the prognosis and healing of root perforations include its treatment timeline, extent and location. A small root perforation, sealed immediately and apical to the crest bone and epithelial attachment, presents with a better prognosis. The three most widely recommended materials to seal root perforations have been calcium hydroxide, mineral trioxide aggregate and calcium silicate cements. This review aimed to discuss contemporary therapeutic alternatives to treat root canal perforations. Accordingly, the essential aspects for repairing this deleterious tissue injury will be addressed, including its diagnosis, prognosis, and a discussion about the materials actually suggested to seal root canal perforation.

A clinical classification of the status of the pulp and the root canal system.

Many different classification systems have been advocated for pulp diseases. However, most of them are based on histopathological findings rather than clinical findings which leads to confusion since there is little correlation between them. Most classifications mix clinical and histological terms resulting in misleading terminology and diagnoses. This in turn leads to further confusion and uncertainty in clinical practice when a rational treatment plan needs to be established in order to manage a specific pathological entity. A simple, yet practical classification of pulp diseases which uses terminology related to clinical findings is proposed. This classification will help clinicians understand the progressive nature of the pulp disease processes and direct them to the most appropriate and conservative treatment strategy for each condition. With a comprehensive knowledge of the pathophysiology of pain and inflammation in the pulp tissues, clinicians may accomplish this task with confidence.

Incidental findings in the maxillofacial area with 3-dimensional cone-beam imaging.

INTRODUCTION: The purposes of this study were to evaluate the location, nature, and occurrence of incidental findings in maxillofacial structures on 3-dimensional cone-beam volumetric scans done for dental diagnostic purposes and to look for associations between these findings and symptoms in orthodontic patients. METHODS: Images from 500 consecutive maxillofacial 3-dimensional scans were examined. The patient sample consisted of 252 orthodontic patients, 172 implant patients, 33 endodontic patients, 34 temporomandibular joint (TMJ) disorder patients, and 10 others. RESULTS: The overall rate of incidental findings was 24.6% (123 patients of 500). The highest rate of incidental findings was in the airway area (18.2%), followed by TMJ findings (3.4%), endodontic findings (1.8%), and others (1.2%). In the orthodontic group, the incidences were airway findings, 21.4%; TMJ findings, 5.6%; and endodontic lesions, 2.3%. Only 22% of the airway findings, such as mucosal thickness, polyps, and retention cysts, were correlated with clinical signs and symptoms. CONCLUSIONS: For clinical diagnosis, the data should be interpreted with a full history of clinical signs and symptoms, and with detailed communications with radiological colleagues and other specialists to comprehensively evaluate possible underlying diseases.

Dental anatomical anomalies in Asians and Pacific Islanders.

Dental anatomical anomalies having a significant impact on endodontic diagnosis and treatment are the talon cusp, tuberculated premolars, three-rooted mandibular molars, and C-shaped molars. Asian and Pacific Islander ethnic groups have the highest percentage of these dental anatomical anomalies compared to the general population. As the population of Asians and Pacific Islanders continues to grow in California and other western states, dentists should be aware of the diagnostic and treatment complexities associated with specific patient groups.

[Root canal treatments in a patient with florid cemento-osseous dysplasia].

This article follows the comprehensive dental treatment of a patient who presented with multi periapical radiolucencies on a complete set of periapical radiographs. All the affected teeth were treated and root canal fillings were performed. None of the periapical radiolucencies showed any evidence of a healing process. On a later stage, the lesions have been diagnosed as florid cemento-osseous dysplasia. (In this article the correct diagnosis and treatment will be discussed).

Clinical radiological aspects of primary endodontic lesions with secondary periodontal involvement.

Damage of pulp tissue usually begins in the coronal pulp. Its mistreatment or its lack of on time detection determines the progressive inclusion of the whole endodontic space in its evolution, opening the way of its expansion in the surrounding tissues of the tooth, and on the marginal apical tissue. Aim. The goal of this study was to highlight that the primary endodontic lesions with secondary periodontal implication healed and bone repair was obtained due to a proper disinfection and an adequate sealing of the endodontic system. In primary endodontic lesion with secondary periodontal involvement, endodontic treatment is required in the first stage followed by specific periodontal treatment. The prognosis is good if an appropriate endodontic approach is chosen, depending on the stage of the periodontal disease and the treatment response. The identification of the etiological factors is the most important to establish the appropriate treatment. In all clinical cases selected in this article, the healing tendency was noticed after an adequate disinfection and sealing of the endodontic system.