RESUMO
BACKGROUND: Spreading depolarizations (SDs) occur in 50-60% of patients after surgical treatment of severe traumatic brain injury (TBI) and are independently associated with unfavorable outcomes. Here we performed a pilot study to examine the relationship between SDs and various types of intracranial lesions, progression of parenchymal damage, and outcomes. METHODS: In a multicenter study, fifty patients (76% male; median age 40) were monitored for SD by continuous electrocorticography (ECoG; median duration 79 h) following surgical treatment of severe TBI. Volumes of hemorrhage and parenchymal damage were estimated using unbiased stereologic assessment of preoperative, postoperative, and post-ECoG serial computed tomography (CT) studies. Neurologic outcomes were assessed at 6 months by the Glasgow Outcome Scale-Extended. RESULTS: Preoperative volumes of subdural and subarachnoid hemorrhage, but not parenchymal damage, were significantly associated with the occurrence of SDs (P's < 0.05). Parenchymal damage increased significantly (median 34 ml [Interquartile range (IQR) - 2, 74]) over 7 (5, 8) days from preoperative to post-ECoG CT studies. Patients with and without SDs did not differ in extent of parenchymal damage increase [47 ml (3, 101) vs. 30 ml (- 2, 50), P = 0.27], but those exhibiting the isoelectric subtype of SDs had greater initial parenchymal damage and greater increases than other patients (P's < 0.05). Patients with temporal clusters of SDs (≥ 3 in 2 h; n = 10 patients), which included those with isoelectric SDs, had worse outcomes than those without clusters (P = 0.03), and parenchymal damage expansion also correlated with worse outcomes (P = 0.01). In multivariate regression with imputation, both clusters and lesion expansion were significant outcome predictors. CONCLUSIONS: These results suggest that subarachnoid and subdural blood are important primary injury factors in provoking SDs and that clustered SDs and parenchymal lesion expansion contribute independently to worse patient outcomes. These results warrant future prospective studies using detailed quantification of TBI lesion types to better understand the relationship between anatomic and physiologic measures of secondary injury.
Assuntos
Contusão Encefálica/patologia , Contusão Encefálica/fisiopatologia , Depressão Alastrante da Atividade Elétrica Cortical/fisiologia , Hematoma Subdural Agudo/patologia , Hematoma Subdural Agudo/fisiopatologia , Hemorragia Subaracnoídea Traumática/patologia , Hemorragia Subaracnoídea Traumática/fisiopatologia , Adulto , Contusão Encefálica/diagnóstico por imagem , Eletrocorticografia , Feminino , Seguimentos , Escala de Resultado de Glasgow , Hematoma Subdural Agudo/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Índice de Gravidade de Doença , Hemorragia Subaracnoídea Traumática/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Spontaneous rapid resolution of acute subdural hematoma developing secondary to trauma has been reported in the literature, yet it is very rare in pediatric population. The aim of the present review is to analyze mechanisms, characteristics, and outcomes of pediatric acute subdural hematoma cases with spontaneous rapid resolution in conjunction with an exemplary case of ours. CASE DESCRIPTION: A 3-year-old boy was admitted to our emergency department following mild head trauma secondary to a fall from 2 m. He was alert and has a GCS of 15. He had no motor or sensorial deficit on neurological examination. On the emergent brain computed tomography image, an acute subdural hematoma over left frontoparietal lobe was observed. There was a midline shift of 8.3 mm and the width of the hematoma at the thickest portion was 11.2 mm. Surgery was postponed with a close neurological follow-up of the patient in pediatric intensive care unit, due to his well neurological status without any increased ICP findings. On the fourth hour follow-up head CT image, amount of midline shift and hematoma thickness were observed to have regressed dramatically. At the second week, the hematoma resorbed totally with only conservative approach, and he was discharged to home in well status. DISCUSSION AND CONCLUSION: Analysis of 12 pediatric patients revealed a mean and median ages of 6.87 and 3.9 years, respectively (range = 8 months-18 years). Causes for ASH development were fall, traffic accident, struggle, and child abuse. Main clinical presentations were with depressed sensorium, coma, stupor, drowsiness, headache, motor weakness, lethargy, and seizure. Close follow-up with conservative treatment should be mode of approach in pediatric patients with ASH, if neurological and radiological findings are favorable. However, if patients' neurological status deteriorates after admission to hospital, surgery should be conveyed with no further delay.
Assuntos
Gerenciamento Clínico , Hematoma Subdural Agudo/fisiopatologia , Recuperação de Função Fisiológica/fisiologia , Pré-Escolar , Hematoma Subdural Agudo/diagnóstico , Hematoma Subdural Agudo/terapia , Humanos , Masculino , Resultado do TratamentoAssuntos
Velocidade do Fluxo Sanguíneo , Edema Encefálico/fisiopatologia , Lesões Encefálicas Traumáticas/fisiopatologia , Falência Renal Crônica/terapia , Artéria Cerebral Média/diagnóstico por imagem , Diálise Renal/efeitos adversos , Estado Epiléptico/fisiopatologia , Resistência Vascular , Idoso , Barreira Hematoencefálica/metabolismo , Contusão Encefálica/complicações , Contusão Encefálica/diagnóstico por imagem , Contusão Encefálica/metabolismo , Contusão Encefálica/fisiopatologia , Edema Encefálico/diagnóstico por imagem , Edema Encefálico/etiologia , Edema Encefálico/metabolismo , Lesões Encefálicas Traumáticas/complicações , Lesões Encefálicas Traumáticas/diagnóstico por imagem , Lesões Encefálicas Traumáticas/metabolismo , Hemorragia Cerebral Traumática/complicações , Hemorragia Cerebral Traumática/diagnóstico por imagem , Hemorragia Cerebral Traumática/metabolismo , Hemorragia Cerebral Traumática/fisiopatologia , Transtornos da Consciência/etiologia , Transtornos da Consciência/metabolismo , Transtornos da Consciência/fisiopatologia , Cefaleia/etiologia , Cefaleia/metabolismo , Cefaleia/fisiopatologia , Hematoma Subdural Agudo/complicações , Hematoma Subdural Agudo/diagnóstico por imagem , Hematoma Subdural Agudo/metabolismo , Hematoma Subdural Agudo/fisiopatologia , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/metabolismo , Masculino , Artéria Cerebral Média/fisiopatologia , Monitorização Fisiológica , Náusea/etiologia , Náusea/metabolismo , Náusea/fisiopatologia , Fluxo Pulsátil , Estado Epiléptico/etiologia , Estado Epiléptico/metabolismo , Ultrassonografia Doppler Transcraniana , Vômito/etiologia , Vômito/metabolismo , Vômito/fisiopatologiaRESUMO
Acute subdural hemorrhage (ASDH) is a frequent and devastating consequence of traumatic brain injury. Tissue damage develops rapidly and makes treatment even more difficult. Management of increased intracranial pressure (ICP) due to extravasated blood volume and brain swelling is often insufficient to control all adverse effects of ASDH. In addition to sheer volume, spontaneously triggered cortical spreading depression (CSD) that leads to cell death following ischemia or trauma may contribute to injury development after ASDH. Therefore, we explored the occurrence of CSD by tissue impedance (IMP) measurement in a rat model subjected to ASDH. IMP and intraventricular and mean arterial pressure were monitored before (baseline), during (blood infusion), and after ASDH for 3 h.Tissue impedance increased by around 203% of baseline during subdural infusion of 300 µl of autologous, venous blood and dropped back to baseline within 22 min. Fifty-six minutes after the start of ASDH a cluster of four short-lasting (3-3.5 min; 140-160% of baseline) IMP increases started that reflected spontaneous CSDs. This pattern presumes that CSD occurs early after ASDH and therefore may contribute to the rapid lesion development in this disease.
Assuntos
Córtex Cerebral/fisiopatologia , Depressão Alastrante da Atividade Elétrica Cortical/fisiologia , Hematoma Subdural Agudo/patologia , Hematoma Subdural Agudo/fisiopatologia , Pressão Intracraniana/fisiologia , Animais , Edema Encefálico/etiologia , Eletrodos Implantados , Eletroencefalografia , Masculino , Ratos , Ratos Sprague-DawleyAssuntos
Hematoma Subdural Agudo/fisiopatologia , Leucemia Mieloide/complicações , Placa Aterosclerótica/etiologia , Sarcoma/complicações , Adulto , Antígenos CD/metabolismo , Escala de Coma de Glasgow , Humanos , Leucemia Mieloide/diagnóstico por imagem , Masculino , Neuroimagem , Sarcoma/diagnóstico por imagemRESUMO
An acute subdural hematoma (ASDH) induces pathomechanisms which worsen outcome after traumatic brain injury, even after a small hemorrhage. Synergistic effects of a small ASDH on brain damage are poorly understood, and were studied here using neuromonitoring for 10 h in an injury model of controlled cortical impact (CCI) and ASDH. Pigs (n = 32) were assigned to 4 groups: sham, CCI (2.5 m/s), ASDH (2 ml) and CCI + ASDH. Intracranial pressure was significantly increased above sham levels by all injuries with no difference between groups. CCI and ASDH reduced ptiO(2) by a maximum of 36 ± 9 and 26 ± 11%, respectively. The combination caused a 31 ± 11% drop. ASDH alone and in combination with CCI caused a significant elevation in extracellular glutamate, which remained increased longer for CCI + ASDH. The same two groups had significantly higher peak lactate levels compared to sham. Somatosensory evoked potential (SSEP) amplitude was persistently reduced by combined injury. These effects translated into significantly elevated brain water content and histological damage in all injury groups. Thus, combined injury had stronger effects on glutamate and SSEP when compared to CCI and ASDH, but no clear-cut synergistic effects of 2 ml ASDH on trauma were observed. We speculate that this was partially due to the CCI injury severity.
Assuntos
Lesões Encefálicas/complicações , Hematoma Subdural Agudo/etiologia , Animais , Edema Encefálico/etiologia , Edema Encefálico/patologia , Edema Encefálico/fisiopatologia , Lesões Encefálicas/patologia , Lesões Encefálicas/fisiopatologia , Circulação Cerebrovascular , Modelos Animais de Doenças , Potenciais Somatossensoriais Evocados , Ácido Glutâmico/metabolismo , Hematoma Subdural Agudo/patologia , Hematoma Subdural Agudo/fisiopatologia , Pressão Intracraniana , Ácido Láctico/metabolismo , Masculino , Monitorização Fisiológica , Sus scrofaRESUMO
Acute subdural hematoma (ASDH) patients presenting in a severe condition tend to have poor outcomes due to the significant brain edema required to maintain the ICP at less than 20-25 mmHg. This study compared the surgical outcomes of 16 critically ill patients with ASDH who underwent hematoma irrigation with trephination therapy (HITT) based on their initial ICP values. The initial mean GCS score upon admission was four. A unilateral dilated pupil was seen in one and bilateral dilated pupils were seen in seven patients. The co-existence of a brain contusion was seen in seven patients, brain swelling was noted in six patients, and both basal cistern effacement and a midline shift greater than 5 mm were observed in all patients. The mean initial ICP value was 45 mmHg (range: 3 to 85 mmHg). Ten patients (62.5%) underwent a rapid external decompression to evacuate the hematoma. By using the Glasgow Outcome Scale upon discharge a score of good recovery (GR) was assigned to two (12.5 %), moderate disability (MD) to four (25.0 %), vegetative state (VS) to two (12.5 %), and death (D) to eight (50.0 %) patients. All six patients who showed an initial ICP greater than 60 mmHg died despite intensive care. Eight patients who showed an initial ICP less than 40 mmHg had a favorable outcome, but two patients deteriorated due to a traumatic cerebrovascular disorder. It seems that the initial ICP monitoring with HITT for ASDH patients in critical condition may be an important factor for predicting both surgical outcome and clinical course.
Assuntos
Hematoma Subdural Agudo/fisiopatologia , Hematoma Subdural Agudo/cirurgia , Pressão Intracraniana/fisiologia , Monitorização Fisiológica/métodos , Irrigação Terapêutica/métodos , Trepanação/métodos , Adulto , Idoso , Cuidados Críticos , Feminino , Escala de Resultado de Glasgow , Humanos , Cuidados Intraoperatórios , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia Computadorizada por Raios X/métodos , Adulto JovemRESUMO
Although criteria for surgical treatment of acute subdural hematoma (SDH) have been proposed, interaction exists between SDH, midline shift (MLS), and intracranial pressure (ICP). Based on our half sphere finite-element model (FEM) of the supratentorial brain parenchyma, tools for ICP estimation using SDH thickness (SDHx) and MLS were developed. We performed 60 single load step, structural static analyses, simulating a left-sided SDH compressing the cerebral hemispheres. The Young's modulus was taken as 10,000 Pa. The ICP loads ranged from 10 to 80 mmHg with Poisson's ratios between 0.25 and 0.49. The SDHx and the MLS results were stored in a lookup table. An ICP estimation equation was derived from these data and then was converted into a nomogram. Numerical convergence was achieved in 49 model analyses. Their SDHx ranged from 0.79 to 28.3 mm, and the MLS ranged from 1.5 to 16.9 mm. The estimation formula was log(ICP) = 0.614-0.520 log(SDHx) + 1.584 log(MLS). Good correlations were observed between invasive ICP measurements and those estimated from preoperative SDHx and MLS data on images using our model. These tools can be used to estimate ICP noninvasively, providing additional information for selecting the treatment strategy in patients with SDH.
Assuntos
Hematoma Subdural Agudo/fisiopatologia , Pressão Intracraniana , Modelos Neurológicos , Nomogramas , HumanosRESUMO
Mass evacuation with decompressive craniotomy is considered a standard intervention for acute subdural hematoma (ASDH). However, hemispheric swelling complicates the intraoperative and postoperative management of ASDH patients, and previous studies have revealed that this approach can damage ischemic/reperfusion (I/R) injury. Few studies have focused on the cerebrovascular response following traumatic brain injury (TBI). To characterize the relative cerebral blood flow (rCBF) before and after removal of the hematoma, rats were injured by a subdural infusion of 400 µL of venous blood or paraffin oil. MRI scans were performed. Then, we monitored cortical rCBF during hematoma removal in real time using laser speckle imaging (LSCI) in ASDH rats. The CBF of arteriovenous and capillary regions were quantified and normalized to their own baseline values via a custom algorithm. In the sham group, the cortical CBF was higher post-craniotomy than pre-craniotomy. However, in the hematoma injection group, the CBF of arteries and capillaries was higher while the venous CBF was lower post-craniotomy than pre-craniotomy. The difference in the changes in vein CBF that occurred between the two groups was statistically significant. The three components of the vascular system showed heterogeneous responses to craniotomy, which may be the basis for secondary brain injury.
Assuntos
Córtex Cerebral/metabolismo , Circulação Cerebrovascular/fisiologia , Hematoma Subdural Agudo/diagnóstico por imagem , Animais , Lesões Encefálicas/cirurgia , Lesões Encefálicas Traumáticas/cirurgia , Craniotomia/métodos , Hematoma Subdural Agudo/fisiopatologia , Masculino , Ratos , Ratos Sprague-DawleyRESUMO
INTRODUCTION: The most frequent consequences of a traumatic brain injury are acute subdural (SDH) and epidural hematoma (EDH), which usually require a surgical treatment. Most of the factors affecting the prognosis have been analyzed on a wide group of traumatic brain injuries. Nonetheless, there are few studies analyzing factors influencing the prognosis regarding patients with EDH and SDH. The aim of the study is to identify factors which have prognostic value in relation to 6-month outcome of patients undergoing surgery for acute hematoma. PATIENTS AND METHODS: The study included a group of 128 patients with isolated craniocerebral injuries. The patients were divided into two groups, namely a group of 28 patients operated on due to epidural hematoma and a group of 100 patients operated on due to acute subdural hematoma. All patients were operated and treated in the Department of Neurosurgery at the Medical University in Lublin from 1.10.2014 to 31.08.2017. The following factors from the groups were analyzed: demographic data, physiological factors, laboratory factors, computed tomography scan characteristics, and time between the trauma and the surgery. All the factors were correlated with six-month outcome in Glasgow outcome scale. RESULTS: The univariate analysis has confirmed the influence of many factors affecting the outcomes. CONCLUSION: It is interesting that the factors such as GSC score, saturation, respiratory rate, and systolic blood pressure were associated with outcome with highly statistically significant differences in both group. These are factors that, with an appropriate treatment, could be normalized at the place of the accident.
Assuntos
Hematoma Epidural Craniano/cirurgia , Hematoma Subdural Agudo/cirurgia , Adulto , Idoso , Pressão Sanguínea , Traumatismos Craniocerebrais/diagnóstico por imagem , Traumatismos Craniocerebrais/fisiopatologia , Traumatismos Craniocerebrais/cirurgia , Feminino , Escala de Coma de Glasgow , Escala de Resultado de Glasgow , Hematoma Epidural Craniano/diagnóstico por imagem , Hematoma Epidural Craniano/fisiopatologia , Hematoma Subdural Agudo/diagnóstico por imagem , Hematoma Subdural Agudo/fisiopatologia , Humanos , Hipóxia , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos , Prognóstico , Taxa Respiratória , Tomografia Computadorizada por Raios XRESUMO
A rare case is described of acute disseminated intravascular coagulation (DIC) following isolated mild head injury with acute subdural haematoma, coagulopathy onset preceding craniotomy. Surgical treatment of the cause followed by swift diagnosis and treatment soon after surgery enabled a good outcome. Post-operative recollection of subdural and extadural blood was treated by further surgery. DIC following isolated mild head injury without axonal damage is rare, but fatal if missed. Thrombocytopaenia in head injured patients should be investigated expediently. Post-operative interim imaging (if not standard practice) should also be considered to exclude haemorrhagic recollection requiring further surgery.
Assuntos
Coagulação Intravascular Disseminada/etiologia , Traumatismos Cranianos Fechados/complicações , Hematoma Subdural Agudo/complicações , Adulto , Encéfalo/diagnóstico por imagem , Encéfalo/metabolismo , Encéfalo/fisiopatologia , Craniotomia , Descompressão Cirúrgica , Coagulação Intravascular Disseminada/fisiopatologia , Diagnóstico Precoce , Serviços Médicos de Emergência/métodos , Serviços Médicos de Emergência/normas , Traumatismos Cranianos Fechados/diagnóstico por imagem , Traumatismos Cranianos Fechados/fisiopatologia , Hematoma Epidural Craniano/complicações , Hematoma Epidural Craniano/diagnóstico por imagem , Hematoma Epidural Craniano/fisiopatologia , Hematoma Subdural Agudo/diagnóstico por imagem , Hematoma Subdural Agudo/fisiopatologia , Humanos , Masculino , Tempo de Tromboplastina Parcial , Plasma , Transfusão de Plaquetas , Espaço Subdural/diagnóstico por imagem , Espaço Subdural/patologia , Espaço Subdural/fisiopatologia , Trombocitopenia/etiologia , Tromboplastina/metabolismo , Tomografia Computadorizada por Raios X , Resultado do Tratamento , ViolênciaRESUMO
The majority of acute post-traumatic subdural hematomas (ASDH) require urgent surgical evacuation. Spontaneous resolution of ASDH has been reported in some cases. We report here on a case of a patient with a large amount of ASDH that was rapidly reduced. A 61-yr-old man was found unconscious following a high speed motor vehicle accident. On initial examination, his Glasgow Coma Score scale was 4/15. His pupils were fully dilated and non-reactive to bright light. Brain computed tomography (CT) showed a massive right-sided ASDH. The decision was made to treat him conservatively because of his poor clinical condition. Another brain CT approximately 14 hr after the initial scan demonstrated a remarkable reduction of the previous ASDH and there was the new appearance of high density in the subdural space adjacent to the falx and the tentorium. Thirty days after his admission, brain CT revealed chronic SDH and the patient underwent surgery. The patient is currently able to obey simple commands. In conclusion, spontaneous rapid resolution/reduction of ASDH may occur in some patients. The mechanisms are most likely the result of dilution by cerebrospinal fluid and the redistribution of hematoma especially in patients with brain atrophy.
Assuntos
Hematoma Subdural Agudo , Acidentes de Trânsito , Atrofia , Encéfalo/patologia , Escala de Coma de Glasgow , Hematoma Subdural Agudo/patologia , Hematoma Subdural Agudo/fisiopatologia , Hematoma Subdural Agudo/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Espaço Subdural/diagnóstico por imagem , Resultado do TratamentoRESUMO
Blunt and rotational head impacts due to vehicular collisions, falls and contact sports cause relative motion between the brain and skull. This increases the normal and shear stresses in the (skull/brain) interface region consisting of cerebrospinal fluid (CSF) and subarachnoid space (SAS) trabeculae. The relative motion between the brain and skull can explain many types of traumatic brain injuries (TBI) including acute subdural hematomas (ASDH) and subarachnoid hemorrhage (SAH) which is caused by the rupture of bridging veins that transverse from the deep brain tissue to the superficial meningeal coverings. The complicated geometry of the SAS trabeculae makes it impossible to model all the details of the region. Investigators have compromised this layer with solid elements, which may lead to inaccurate results. In this paper, the failure of the cerebral blood vessels due to the head impacts have been investigated. This is accomplished through a global/local modelling approach. Two global models, namely a global solid model (GSM) of the skull/brain and a global fluid model (GFM) of the SAS/CSF, were constructed and were validated. The global models were subjected to two sets of impact loads (head injury criterion, HIC = 740 and 1044). The relative displacements between the brain and skull were determined from GSM. The CSF equivalent fluid pressure due to the impact loads were determined by the GFM. To locally study the mechanism of the injury, the relative displacement between the brain and skull along with the equivalent fluid pressure were implemented into a new local solid model (LSM). The strains of the cerebral blood vessels were determined from LSM. These values were compared with their relevant experimental ultimate strain values. The results showed an agreement with the experimental values indicating that the second impact (HIC = 1044) was strong enough to lead to severe injury. The global/local approach provides a reliable tool to study the cerebral blood vessel ruptures leading to ASDH and/or SAH.
Assuntos
Encéfalo/fisiopatologia , Veias Cerebrais/lesões , Veias Cerebrais/fisiopatologia , Traumatismos Cranianos Fechados/fisiopatologia , Movimentos da Cabeça , Hematoma Subdural Agudo/fisiopatologia , Modelos Neurológicos , Hemorragia Subaracnoídea Traumática/fisiopatologia , Encéfalo/irrigação sanguínea , Simulação por Computador , Módulo de Elasticidade , Hematoma Subdural Agudo/etiologia , Humanos , Modelos Cardiovasculares , Ruptura/complicações , Ruptura/fisiopatologia , Estresse Mecânico , Hemorragia Subaracnoídea Traumática/etiologiaRESUMO
Traumatic brain injury is a leading cause of disability and mortality. Finite element-based head models are promising tools for enhanced head injury prediction, mitigation and prevention. The reliability of such models depends heavily on adequate representation of the brain-skull interaction. Nevertheless, the brain-skull interface has been largely simplified in previous three-dimensional head models without accounting for the fluid behaviour of the cerebrospinal fluid (CSF) and its mechanical interaction with the brain and skull. In this study, the brain-skull interface in a previously developed head model is modified as a fluid-structure interaction (FSI) approach, in which the CSF is treated on a moving mesh using an arbitrary Lagrangian-Eulerian multi-material formulation and the brain on a deformable mesh using a Lagrangian formulation. The modified model is validated against brain-skull relative displacement and intracranial pressure responses and subsequently imposed to an experimentally determined loading known to cause acute subdural haematoma (ASDH). Compared to the original model, the modified model achieves an improved validation performance in terms of brain-skull relative motion and is able to predict the occurrence of ASDH more accurately, indicating the superiority of the FSI approach for brain-skull interface modelling. The introduction of the FSI approach to represent the fluid behaviour of the CSF and its interaction with the brain and skull is crucial for more accurate head injury predictions.
Assuntos
Encéfalo/fisiopatologia , Líquido Cefalorraquidiano/metabolismo , Simulação por Computador , Hematoma Subdural Agudo/diagnóstico , Hematoma Subdural Agudo/fisiopatologia , Crânio/fisiopatologia , Aceleração , Encéfalo/irrigação sanguínea , Análise de Elementos Finitos , Humanos , Pressão Intracraniana , Reprodutibilidade dos Testes , Estresse MecânicoRESUMO
OBJECTIVE: The treatment of acute subdural hematoma (ASDH) consists mainly of surgical evacuation of the hematoma. It is conceivable that early preoperative neuroprotection with hypertonic/hyperoncotic treatment (HHT) can improve survival rates. The present study investigated the benefit of treatment with hypertonic/hyperoncotic solution on functional and histologic outcome as supportive therapy accompanying surgical intervention. DESIGN: Laboratory experiment. SETTING: University laboratory. SUBJECTS: Male Sprague-Dawley rats weighing 296-350 g (n = 56). INTERVENTIONS: ASDH was induced through subdural infusion of 400 microL of autologous venous blood. Thirty minutes after subdural blood infusion, the rats received either HyperHAES (7.2% saline/6% hydroxyethyl starch) or vehicle (NaCl 0.9%) intravenously, followed by surgical evacuation of the hematoma 1 hr after ASDH induction in those rats scheduled for surgical treatment. The experiment was divided into two parts: an acute study, which explored acute effects of HHT on blood variables, ASDH-induced changes of intracranial pressure (ICP), and cerebral perfusion pressure (CPP), and a chronic study, which investigated the chronic effects of HHT, surgical blood clot evacuation, and the combination of both on the functional and histologic outcome following ASDH (12 days). MEASUREMENTS AND MAIN RESULTS: In the acute study, HHT expectedly raised the serum sodium concentration and lowered hematocrit. ASDH increased ICP and decreased CPP in all groups. HHT improved CPP by reducing ICP. In the chronic study, all treated groups showed a better recovery with respect to neurologic function and neuronal cell death compared with the vehicle-treated ASDH group. HHT with surgical evacuation or HHT alone improved functional and histologic outcome slightly more than surgical evacuation alone. CONCLUSIONS: In this rat model, HHT led to a decrease of ICP after ASDH. This significantly improved functional and histologic outcome, which was comparable to the effects after blood evacuation alone. The combination of evacuation of subdural blood and early HHT improved histologic outcome further but not significantly, which was due to the strong effects of single treatments and a ceiling effect of the combined treatment in this model.
Assuntos
Hematoma Subdural Agudo/cirurgia , Derivados de Hidroxietil Amido/administração & dosagem , Substitutos do Plasma/administração & dosagem , Solução Salina Hipertônica/administração & dosagem , Animais , Circulação Cerebrovascular/fisiologia , Hematoma Subdural Agudo/patologia , Hematoma Subdural Agudo/fisiopatologia , Pressão Intracraniana/fisiologia , Masculino , Cuidados Pré-Operatórios , Ratos , Ratos Sprague-Dawley , Recuperação de Função Fisiológica/fisiologia , Resultado do TratamentoRESUMO
Traumatic brain injury (TBI) is often complicated by acute subdural hemorrhage (ASDH) with a high mortality rate. The pathophysiological mechanisms behind such an injury type and the contribution of blood to the extent of an injury remain poorly understood. Therefore, the goals of this study were to establish a porcine ASDH model in order to investigate pathomechanisms of ASDH and to compare effects induced by blood or sheer volume. Thus, we infused 2, 5, and 9 mL of blood (up to 15% of intracranial volume), and we compared a 5-mL blood and paraffin oil volume to separate out effects of extravasated blood on brain tissue. An extended neuromonitoring was applied that lasted up to 12 h after injury and included intracranial pressure (ICP), cerebral perfusion pressure (CPP), tissue oxygen concentration (ptiO(2)), biochemical markers (glutamate, lactate), somatosensory evoked potentials (SEP), brain water content, and histological assessment (Lesion Index [LI]). Volume-dependent changes were detected mainly during the first hours after injury. ICP increased to significant levels (p < 0.05) of 36.89 +/- 1.59, 15.52 +/- 0.48, and 11.25 +/- 0.35 mm Hg after 9, 5, and 2 mL of subdural blood, respectively (sham, 4.85 +/- 0.06 mm Hg). The ptiO(2) dropped drastically after 9 mL of subdural blood without recovery in both hemispheres to below 20% of baseline, but was affected little after 2 and 5 mL in the acute monitoring period (maximal drop to 71% of baseline). Later, 5 mL of blood led to a significant increase of ptiO(2) compared to 2 mL ipsilaterally (p < 0.05). Glutamate and lactate showed a comparable pattern with a long-lasting increase after 9 mL of blood and short-lasting changes after 2 and 5 mL. The two smaller volumes caused an increased brain swelling (2 mL, 80.60 +/- 0.34%; 5 mL, 81.20 +/- 0.66%; p < 0.05 vs. sham), a significant LI (sham, 6.4 +/- 1.4; 2 mL, 30.0 +/- 0.95; 5 mL, 32.1 +/- 1.2; p < 0.05 vs. sham), and a reduced SEP amplitude (5 mL, p < 0.05 vs. baseline) at the end of the experiment. A 9-mL led to herniation during the experiment causing dramatical brain swelling and acute histological damage. Comparison of blood volume with paraffin oil showed no significance, indicating that volume alone determines the acute pathophysiological processes leading to a rapidly developing histological damage. Additional effects due to blood contact with brain tissue (e.g., inflammation) may be detected only at later time points (>12 h).
Assuntos
Lesões Encefálicas/complicações , Lesões Encefálicas/fisiopatologia , Encéfalo/fisiopatologia , Hematoma Subdural Agudo/etiologia , Hematoma Subdural Agudo/fisiopatologia , Animais , Encéfalo/metabolismo , Encéfalo/patologia , Edema Encefálico/etiologia , Edema Encefálico/fisiopatologia , Lesões Encefálicas/metabolismo , Modelos Animais de Doenças , Potenciais Somatossensoriais Evocados , Ácido Glutâmico/metabolismo , Hematoma Subdural Agudo/metabolismo , Pressão Intracraniana , Ácido Láctico/metabolismo , Oxigênio/análise , Consumo de Oxigênio/fisiologia , SuínosRESUMO
BACKGROUND: Prior studies have shown that most patients with mild traumatic brain injury or negative computed tomography (CT) scans of the head rarely decline or require neurosurgical interventions. One common reason for a delayed decline is an intracranial hemorrhage that presents within 24-48 hours. This is typically seen in elderly patients and/or patients on antiplatelet or anticoagulation agents. We describe a case of a delayed subdural hemorrhage presenting in a young adult not on any antiplatelet or anticoagulation therapy. CASE DESCRIPTION: A 19-year-old male presented to the emergency department after being involved in a motor vehicle accident. He had a Glasgow Coma Scale of 15, and an initial CT was negative for any intracranial hemorrhage or pathology, so he was then admitted to the intensive care unit for further care. The patient received 1 dose of aspirin 325 mg the following day for treatment of blunt cerebrovascular injury. Six hours later he reported a severe headache and had an episode of emesis with a subsequent rapid neurologic decline. Repeat CT showed an acute right subdural hematoma, and he underwent an emergent right decompressive hemicraniectomy. CONCLUSIONS: In rare cases, patients with negative initial head CT scans neurologically deteriorate as a result of a delayed acute subdural hematoma. We present an unusual case of a young patient on no medications with no CT findings of an intracranial injury who neurologically declined due to a delayed acute subdural hematoma.
Assuntos
Concussão Encefálica/complicações , Hematoma Subdural Agudo/etiologia , Acidentes de Trânsito , Encéfalo/diagnóstico por imagem , Concussão Encefálica/diagnóstico por imagem , Concussão Encefálica/fisiopatologia , Concussão Encefálica/terapia , Hematoma Subdural Agudo/diagnóstico por imagem , Hematoma Subdural Agudo/fisiopatologia , Hematoma Subdural Agudo/terapia , Humanos , Masculino , Fatores de Tempo , Adulto JovemRESUMO
AIM: Acute subdural haematoma (ASDH) is seldom an isolated lesion and it is difficult to understand the mechanisms which determine the poor prognosis associated to this occurrence. Aim of this study was estimating the outcome of patients with ASDH without any companion lesions by analysing the haematoma volume, its thickness and midline shift. METHODS: Twenty-eight severely head injured patients (Glasgow Coma Scale, GCS =/<8) with isolated unilateral ASDH admitted in intensive care unit (ICU) were retrospectively studied. The haematoma thickness, the midline shift, the ASDH volume were obtained from the first emergency computerized tomography (CT) scan and analysed by a computer assisted programme (Osiris). Patients' outcome was scored according to the Glasgow Outcome Scale (GOS) 6 months after the event. According to their GOS the patients were further divided in 2 groups (favourable outcome: GOS 4-5, poor outcome: GOS 1-2-3). RESULTS: Midline shift ranged from 0 to 19.2 mm; we found a larger midline shift in those patients who died and in patients with severe disability or vegetative state 6 months after the trauma. CONCLUSION: The presence and size of midline shift was a more important determinant of outcome than ASDH volume or its thickness.
Assuntos
Hematoma Subdural Agudo/diagnóstico por imagem , Hematoma Subdural Agudo/fisiopatologia , Tomografia Computadorizada por Raios X , Índices de Gravidade do Trauma , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Diagnóstico por Computador , Feminino , Escala de Coma de Glasgow , Hematoma Subdural Agudo/mortalidade , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos RetrospectivosRESUMO
Acute subdural hematoma (ASDH) is associated with high morbidity and mortality. Whether the volume effect of the hematoma and increase of intracranial pressure (ICP) or the local effect of blood are responsible for this severe pathophysiology is unclear. Therefore, we compared subdural infusion of autologous blood and paraffin oil in a rat model of ASDH. In a histological study, we investigated the effects on acute ICP, cerebral perfusion pressure (CPP), cerebral blood flow (CBF), tissue oxygen changes, and brain damage at 2, 24, and 96 h post-infusion. Inflammatory reaction was analyzed by immuno-staining for microglia (ionized calcium binding adaptor molecule 1 [Iba1]) and activated astrocytes (glial fibrillary acidic protein [GFAP]). Besides acute ICP and CBF changes, we investigated the development of behavior (neuroscore and beamwalk test) for up to 4 days after injury in a behavioral study. Despite comparably increased ICP, there was a more pronounced lesion growth in the blood infusion group during the first 96 h. Further, there was an increased peri-lesional immunoreactive area of Iba1 and GFAP 96 h post-infusion, primarily in the blood infusion group, whereas hippocampal damage was comparable in both infusion groups. In the behavioral evaluation, paraffin-infused animals showed a better recovery, compared with the blood infusion group. In conclusion, comparable acute time-course of ICP, CPP, and CBF clearly indicates that the differences in lesion size, inflammatory reaction, and behavioral deficits after blood- and paraffin oil-induced ASDH are partially due to blood constituents. Therefore, current data suggest that subdural hematomas should be completely removed as quickly as possible; decompression alone may not be sufficient to prevent secondary brain damage.