RESUMO
During sleep there is a two- to threefold increase in the incorporation of inorganic orthophosphate-(32)P into a chemical fraction of the brain of the 20-day-old rat. This increase is not in the lipids or nucleic acids, but is associated with an acid-labile phosphate entity of the tissue residue after extraction of these fractions and phosphorus-containing substances of low molecular weight.
Assuntos
Encéfalo/metabolismo , Fosfatos/metabolismo , Sono/metabolismo , Animais , Animais Recém-Nascidos , Química Encefálica , Clorofórmio , Cromatografia em Papel , Técnicas In Vitro , Metanol , Isótopos de Fósforo , Ratos , Extratos de Tecidos/metabolismo , Ácido TricloroacéticoRESUMO
The amount of time that monkeys (Macaca mulatta) slept was reduced after they were given p-chlorophenylalanine, a selective depletor of serotonin in animal tissues. The time spent in the rapid eye movement stage of sleep was unchanged, but the time in other sleep stages decreased. Seven regions of the brain had a 31 to 46 percent decrease in serotonin content; the concentration of cerebellar serotonin increased by 44 percent.