Spread of a methicillin-resistant staphylococcus aureus clone isolated from bacteremia in elderly patients in a Brazilian general hospital
Rev. panam. infectol
; 9(2): 18-22, abr.-jun. 2007.
Article
em En
| LILACS
| ID: lil-516870
Biblioteca responsável:
BR31.1
ABSTRACT
A study of the genomic diversity of MRSA strains isolated from elderly patients with infection/colonization in three repeated prevalence, cross sectional studies was performed in the 1999-2000 period. In this study, 13 MRSA isolates from blood cultures and 5 from rectal and nare cultures were obtained from 18 patients (13 elderly and 5 adults). Most of the patients were being treated with two or more antimicrobials (83.3%), had insertion of invasive devices (88.9%) and were managed in ICU (Intensive Care Unit) and/or surgical units (66.7%). MIC (Minimum Inhibitory Concentration) data showed that 88.9% of the MRSA strains were resistant to high concentrations of oxacillin (MIC > 256 ìg/mL), 94.5% of the MRSA carried the mecA gene in their genome, and most (65.0%) of the isolates were indistinguishable according to their DNA fingerprinting generated by PFGE (Pulsed-field gel electrophoresis). Although PFGE typing was performed with a few MRSA isolates, our results demonstrate that one MRSA clone was associated with infection/colonization in patients with an obvious connection among five out of eleven patients who stayed in the same clinic and ICU during the same period. Hospital acquired infection, a major silent epidemy, is associated with prolonged hospital stay and high mortality rate and its cause must be better evaluated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Oxacilina
/
Staphylococcus aureus
/
Infecção Hospitalar
/
Resistência a Meticilina
/
Células Clonais
/
Infecções
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. panam. infectol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Brasil