Serine and SH-proteinase inhibitors from Enterolobium contortisiliquum beans: purification and preliminary characterization
Braz. j. med. biol. res
; 20(6): 767-70, 1987. ilus
Article
em En
| LILACS
| ID: lil-77435
Biblioteca responsável:
BR26.1
ABSTRACT
Two types inhibitors were prufied from Enterolobium contortisiliquum beans. The inhibitor of serine-proteinases inhibited trypasin (Ki = 5 nM) chymostrypsin (Ki = 10 nM) and plasma kallikrein, but not tissue kallikreins. The molecular weight is approximately 23 KDal and two polypeptide chains detected after reduction. The second inhibitor with activity directed against SH-proteinase was isolated by CM-papain-Sepharose. The molecular weight is approximately 60 KDal and only one polupeptide chain was detected after reduction. Papain (Ki = 0.6 nM) and bromelain are inhibited
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Inibidores de Proteases
/
Serina Proteases
/
Fabaceae
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1987
Tipo de documento:
Article
/
Congress and conference
/
Project document