Artificial reconstituted pulmonary surfactant in prevention and treatment of respiratory distress syndrome in neonates.
Zhongguo Yao Li Xue Bao
; 18(2): 182-4, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-10072978
ABSTRACT
AIM:
To test an artificial reconstituted pulmonary surfactant (APS) for prevention and treatment of respiratory distress syndrome (RDS).METHODS:
A membrane-formed method combined with supersonic dispersing was used to prepare APS. A pulsating bubble surface tension measurement was established to compare surface properties of APS with natural pulmonary surfactant (NPS). A preliminary clinical trial was made for prevention and treatment of RDS.RESULTS:
The APS reduced surface tension from 44.0 mN/m to < 1.0 mN/m in vitro. The changes of APS lipid contents were < 5% of labeled content at 37 degrees C. Clinical trial showed that the APS prevented RDS in 20/20 and cured RDS in 2/2 premature neonates.CONCLUSION:
The APS had good surface properties similar to NPS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilgliceróis
/
Síndrome do Desconforto Respiratório do Recém-Nascido
/
1,2-Dipalmitoilfosfatidilcolina
/
Surfactantes Pulmonares
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Zhongguo Yao Li Xue Bao
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
China