Vascular endothelial growth factor in porcine coronary arteries following balloon angioplasty.
J Invest Surg
; 12(1): 15-23, 1999.
Article
em En
| MEDLINE
| ID: mdl-10084675
ABSTRACT
The present study was a preliminary inquiry into the presence of vascular endothelial growth factor (VEGF) in a model of coronary artery response to injury. We examined domestic pigs who had received a diet enriched in saturated fat and cholesterol and undergone balloon angioplasty of one or more coronary arteries. Immunohistochemical analysis of the coronary arteries 2 months after injury revealed the presence of VEGF distributed throughout the media and neointima of the angioplasty lesions and in association with blood vessels in the adventitia and those vessels growing into the base of the neointima. VEGF was also detected in areas of dietary-induced intimal proliferation. This study provided the first immunochemical demonstration of VEGF occuring naturally in a pig model of coronary response to injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
/
Angioplastia Coronária com Balão
/
Fatores de Crescimento Endotelial
/
Linfocinas
/
Vasos Coronários
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Invest Surg
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos