Anandamide activates human platelets through a pathway independent of the arachidonate cascade.
FEBS Lett
; 447(2-3): 277-82, 1999 Mar 26.
Article
em En
| MEDLINE
| ID: mdl-10214961
ABSTRACT
Anandamide (arachidonoylethanolamide, AnNH) is shown to activate human platelets, a process which was not inhibited by acetylsalicylic acid (aspirin). Unlike AnNH, hydroperoxides generated thereof by lipoxygenase activity, and the congener (13-hydroxy)linoleoylethanolamide, were unable to activate platelets, though they counteracted AnNH-mediated stimulation. On the other hand, palmitoylethanolamide neither activated human platelets nor blocked the AnNH effects. AnNH inactivation by human platelets was afforded by a high-affinity transporter, which was activated by nitric oxide-donors up to 225% of the control. The internalized AnNH could thus be hydrolyzed by a fatty acid amide hydrolase (FAAH), characterized here for the first time.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canabinoides
/
Ativação Plaquetária
/
Ácidos Araquidônicos
Limite:
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Itália