Reversal of methotrexate resistance in human squamous carcinoma cells by SQM1-liposome.
Anticancer Res
; 19(1A): 251-4, 1999.
Article
em En
| MEDLINE
| ID: mdl-10226550
ABSTRACT
SQM1, a membrane protein associated with methotrexate (MTX) transport was incorporated into unilamellar vesicles, forming. SQM1-Liposome. Human squamous carcinoma of the head and neck (SqCHN) cells resistant to MTX with defective MTX transport and low SQM1 expression were treated with SQM1-Liposome. SQM1 content was found to be increased in these treated SqCHN cells by radioimmunoassay. Concurrent increases in MTX uptake and MTX cytotoxicity in these treated SqCHN cells were found. The ability to reverse MTX-resistance in vitro opens further possibilities for in vivo applications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Moléculas de Adesão Celular
/
Metotrexato
/
NADH NADPH Oxirredutases
/
Antimetabólitos Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos