MRI changes during water loading in patients with polydipsia and intermittent hyponatremia.
Am J Psychiatry
; 156(6): 958-60, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10360142
ABSTRACT
OBJECTIVE:
Patients with polydipsia and intermittent hyponatremia have greater ventricle-brain ratios (VBRs) than matched patients without polydipsia and intermittent hyponatremia and normal subjects. Unlike previous studies, this study controlled for the impact of water loading when examining the volume of intracranial structures.METHOD:
Under controlled conditions, eight male schizophrenic patients with polydipsia and intermittent hyponatremia were first assigned to either normal fluid intake or oral water loading and then the alternative condition the following day. Magnetic resonance imaging (MRI) volumetric measurements were made with the use of a standardized protocol.RESULTS:
During water loading, total VBR and lateral ventricle volume significantly decreased by 13.1% and 12.6%, respectively. A strong association between change in serum sodium concentration and change in VBR was noted across conditions.CONCLUSIONS:
These findings indicate that 1) water loading does not account for the diminished brain volume observed in patients with polydipsia and intermittent hyponatremia in previous studies, and 2) hyponatremia can significantly alter brain morphology on MRI.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Intoxicação por Água
/
Encéfalo
/
Imageamento por Ressonância Magnética
/
Ingestão de Líquidos
/
Hiponatremia
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos