Positive selection of natural autoreactive B cells.
Science
; 285(5424): 113-6, 1999 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-10390361
ABSTRACT
Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Autoantígenos
/
Subpopulações de Linfócitos B
/
Antígenos Thy-1
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos