Sulfation of thyroid hormone by estrogen sulfotransferase.
J Clin Endocrinol Metab
; 84(7): 2577-80, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10404840
ABSTRACT
Sulfation is one of the pathways by which thyroid hormone is inactivated. Iodothyronine sulfate concentrations are very high in human fetal blood and amniotic fluid, suggesting important production of these conjugates in utero. Human estrogen sulfotransferase (SULT1E1) is expressed among other tissues in the uterus. Here we demonstrate for the first time that SULT1E1 catalyzes the facile sulfation of the prohormone T4, the active hormone T3 and the metabolites rT3 and 3,3'-diiodothyronine (3,3'-T2) with preference for rT3 approximately 3,3'-T2 > T3 approximately T4. Thus, a single enzyme is capable of sulfating two such different hormones as the female sex hormone and thyroid hormone. The potential role of SULT1E1 in fetal thyroid hormone metabolism needs to be considered.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfatos
/
Hormônios Tireóideos
/
Sulfotransferases
/
Isoenzimas
Limite:
Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Holanda