Inhibition of immunoglobulin E production by Poncirus trifoliata fruit extract.
J Ethnopharmacol
; 66(3): 283-8, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10473174
ABSTRACT
Immunoglobulin E (IgE) is the principal immunoglobulin involved in immediate hypersensitivities and chronic allergic diseases. The effect of an aqueous extract of Poncirus trifoliata (L) Raf. (Rutaceae) fruits (PTFE) on in vivo and in vitro IgE production was investigated. PTFE dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin, Bordetella pertussis toxin and aluminum hydroxide gel. PTFE strongly inhibited interleukin 4 (IL-4)-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, PTFE also showed an inhibitory effect on the IgE production. These results suggest that PTFE has an anti-allergic activity by inhibition of IgE production from B cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Imunoglobulina E
/
Extratos Vegetais
/
Linfócitos B
/
Anafilaxia
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Coréia do Sul