Mechanical and excitotoxic lesion of motoneurons: effects of neurotrophins and ciliary neurotrophic factor on survival and regeneration.
Acta Neurochir Suppl
; 73: 31-9, 1999.
Article
em En
| MEDLINE
| ID: mdl-10494338
ABSTRACT
Mechanical lesion of peripheral nerves leads to extensive death of corresponding motoneurons in newborn rodents. The extent of cell death can be significantly reduced by neurotrophic factors. These molecules are produced by glial and neuronal cells and play an important role in supporting survival and regeneration of various neuronal populations in the central nervous system, in particular after mechanical, excitotoxic and ischemic insults. In addition, factors such as ciliary neurotrophic factor and neurotrophin-3 influence glial cell proliferation and survival. We have investigated the role of neurotrophic factors on motoneurons, both in cell culture and after axotomy in vivo. Moreover, the role of excitatory neurotransmission in modulating dendritic architecture of these cells was analyzed. Our data suggest that motoneurons are a suitable model for investigating the complex functional and morphological changes after brain lesion and for the identification of new therapeutic strategies to influence survival and functional recovery under such circumstances.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axotomia
/
Neurônios Motores
/
Fatores de Crescimento Neural
/
Proteínas do Tecido Nervoso
/
Neurotoxinas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Neurochir Suppl
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Alemanha