SHORT COMMUNICATION maternal thyroid dysfunction and c- fos and c- jun expression in rat placenta.
Placenta
; 20(8): 727-31, 1999 Nov.
Article
em En
| MEDLINE
| ID: mdl-10527828
ABSTRACT
Maternal thyroid dysfunction is associated with perturbed fetal brain development and neurological deficits in adulthood in rat and human. To investigate whether these effects occur secondary to placental dysfunction, c- fos and c- jun expression in placenta from normal (euthyroid) and moderately hypothyroid rat dams were investigated by Northern hybridization analysis. In normal placenta, c- fos expression increased by 74 per cent between 16 and 21 days of gestation (dg) whereas c- jun expression declined by 46 per cent. Moderate maternal hypothyroidism depressed placental c- fos expression by 32 per cent at 19 dg, but elevated c- fos and c- jun expression by 139 and 86 per cent, respectively, at 21 dg. Maternal hypothyroidism may therefore induce c- fos/c- jun -related placental dysfunction, but only relatively late in gestation when fetal thyroid function is already established.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Genes jun
/
Genes fos
/
Regulação da Expressão Gênica no Desenvolvimento
/
Hipotireoidismo
/
Troca Materno-Fetal
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Placenta
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Reino Unido