Inhibitor against coagulation factor V after liver transplantation.
Transplantation
; 68(7): 1054-6, 1999 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-10532550
ABSTRACT
A new case of anti-factor V inhibitor is described in a 46-year-old man, who received a liver transplantation for hepatocellular carcinoma, without exposure to bovine thrombin or fibrin glue during the operative course. The inhibition occurred on the 14th postoperative day, while the patient was being treated with oxacillin, azathioprine, and a new immunosuppressive drug, FK506. The inhibition was of short duration (3 days), and no bleeding complication occurred despite a very low plasmatic level of factor V activity and antigen (<5%). Plasma samples drawn after cessation of FK506 disclosed a dose-dependent inhibitory activity when alcoholic solutions of FK506 were exogeneously added; this suggests a possible role of the FK506 drug in the occurrence of this anti-factor V inhibitor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator V
/
Imunoglobulinas
/
Transplante de Fígado
/
Tacrolimo
/
Imunossupressores
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Transplantation
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
França