Natural Product Synthesis on Polymeric Supports-Synthesis and Biological Evaluation of an Indolactam Library.
Angew Chem Int Ed Engl
; 38(19): 2902-2906, 1999 Oct 04.
Article
em En
| MEDLINE
| ID: mdl-10540387
ABSTRACT
Potent activators of protein kinase C in fibroblasts This property was determined for several indolactam V analogues (1) with a new cell-based assay system. This tumor-promoting indole alkaloid and analogues thereof can be synthesized efficiently on the solid phase. The key steps of the combinatorial approach are a regioselective amination of the indole ring and an enantioselective enzymatic reaction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
1999
Tipo de documento:
Article