The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor.
Nat Cell Biol
; 1(5): 267-71, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10559938
ABSTRACT
Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we identify MCH as the ligand for the orphan receptor SLC-1. The rat SLC-1 is activated by nanomolar concentrations of MCH and is coupled to the G protein G alpha i/o. The pattern of SLC-1 messenger RNA expression coincides with the distribution of MCH-containing nerve terminals and is consistent with the known central effects of MCH. Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônios Hipofisários
/
Transcrição Gênica
/
Encéfalo
/
Regulação da Expressão Gênica
/
Receptores de Somatostatina
/
Hormônios Hipotalâmicos
/
Melaninas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Canadá