From a dry bone to a genetic portrait: a case study of sickle cell anemia.
Am J Phys Anthropol
; 111(2): 153-63, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10640943
ABSTRACT
The potential and reliability of DNA analysis for the identification of human remains are demonstrated by the study of a recent bone sample, which represented a documented case of sickle cell anemia. beta-globin gene sequences obtained from the specimen revealed homozygosity for the sickle cell mutation, proving the authenticity of the retrieved residual DNA. Further investigation of mitochondrial and Y chromosome DNA polymorphic markers indicated that this sample came from a male of maternal West African (possibly Yoruban) and paternal Bantu lineages. The medical record, which became available after the DNA analyses had been completed, revealed that it belonged to a Jamaican black male. These findings are consistent with this individual being a descendent of Africans brought to Jamaica during the trans-Atlantic slave trade. This study exemplifies how a "reverse population genetics" approach can be applied to reconstruct a genetic profile from a bone specimen of an unknown individual.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Impressões Digitais de DNA
/
Genética Populacional
/
Anemia Falciforme
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Am J Phys Anthropol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Israel