Evolutionary conservation of the apolipoprotein E-C1-C2 gene cluster on bovine chromosome 18q24.
Gene
; 241(2): 241-5, 2000 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-10675035
ABSTRACT
We have constructed a long-range restriction map spanning about 250 kb on bovine chromosome 18q24. Our results show that the apolipoprotein C2 (APOC2) gene is located about 25 kb from the APOE gene. Four putative CpG islands are also indicated in the map. Interestingly, a minisatellite located in the third intron of the human and mouse APOC2 genes was also found at identical position in the bovine gene and revealed high sequence identity comparing with the two corresponding sequences. By means of cosmid mapping, we further demonstrate that the APOE-APOC1-APOC2 gene cluster is evolutionary conserved in cattle.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas C
/
Apolipoproteínas E
/
Bovinos
/
Mapeamento por Restrição
/
Família Multigênica
/
Evolução Molecular
Limite:
Animals
Idioma:
En
Revista:
Gene
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Samoa americana