A role for CaMKII in T cell memory.
Cell
; 100(4): 457-67, 2000 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-10693762
ABSTRACT
In order to study the role of calcium/calmodulin kinase II (CaMKII) in T cells, we generated transgenic mice expressing CaMKIIgammaB* (T287D), a partially calcium-independent mutant of CaMKIIgammaB. In these mice, the size of the thymus was increased 1.5- to 2-fold, at least in part due to an increase in the lifespan of double-positive (DP) thymocytes. More importantly, there was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype. These T cells were bonafide memory cells as assessed by a variety of criteria. In addition, T cells from wild-type mice acquired calcium-independent CaMKII activity after several rounds of antigen-stimulated division. We propose that CaMKII controls a distinct process of activation-induced cellular differentiation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Proteínas Quinases Dependentes de Cálcio-Calmodulina
/
Memória Imunológica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos