High frequency of loss of heterozygosity for 1p35-p36 (D1S247) in Wilms tumor.
Cancer Genet Cytogenet
; 117(2): 136-9, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-10704684
ABSTRACT
We analyzed the loss of heterozygosity (LOH) for 1p in 18 Wilms tumors using a panel of 11 polymorphic markers. Loss of heterozygosity was identified in 56% of the tumors. The smallest region of overlap was defined for marker D1S247, underlying the 1p35-1p36.1 locus. This is the highest LOH frequency for 1p, or for the well-defined 11p13 and 11p15.5 loci. Based on the fact that tumors of all stages, with both favorable and unfavorable histology, exhibited LOH, we suggest that the 1p35-1p36.1 locus is involved in the etiology of Wilms tumor.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 1
/
Tumor de Wilms
/
Perda de Heterozigosidade
/
Neoplasias Renais
Limite:
Child
/
Child, preschool
/
Humans
/
Infant
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Israel