Oral and systemic factors associated with increased levels of human immunodeficiency virus type 1 RNA in saliva.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 89(4): 432-40, 2000 Apr.
Article
em En
| MEDLINE
| ID: mdl-10760726
ABSTRACT
OBJECTIVE:
The purpose of this investigation was to quantify human immunodeficiency virus type-1 (HIV-1) RNA in saliva and plasma and identify factors associated with increased salivary viral load. STUDYDESIGN:
Forty HIV-1-seropositive adults underwent oral examinations to assess mucosal and periodontal health. Whole saliva was evaluated for HIV-1 RNA titer and occult blood. Plasma viral load, CD4 cell count, HIV-1 staging, and antiretroviral therapy data were obtained from medical records. Associations between salivary titers and oral/systemic parameters were analyzed by means of t tests, Wilcoxon signed rank tests, Pearson's correlation coefficient, and analysis of covariance.RESULTS:
Forty-two percent of the subjects had detectable salivary HIV-1 RNA. Oral titers were highly correlated with plasma viral levels (r = 0.51, P <.01). HIV-associated periodontal disease (in particular, linear gingival erythema), severe gingival inflammation, and absence of antiretroviral therapy were associated with high salivary titers (P <.01).CONCLUSIONS:
Substantial quantities of HIV-1 can be shed in the oral cavity, particularly when inflammatory conditions are present. Salivary titer may be a useful indicator of systemic viral burden.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saliva
/
RNA Viral
/
Saúde Bucal
/
HIV-1
/
Carga Viral
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos