pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia.
J Biol Chem
; 275(22): 16404-7, 2000 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-10764726
ABSTRACT
The physiological role of the inwardly rectifying potassium channel, Kir5.1, is poorly understood, as is the molecular identity of many renal potassium channels. In this study we have used Kir5.1-specific antibodies to reveal abundant expression of Kir5.1 in renal tubular epithelial cells, where Kir4.1 is also expressed. Moreover, we also show that Kir5.1/Kir4.1 heteromeric channel activity is extremely sensitive to inhibition by intracellular acidification and that this novel property is conferred predominantly by the Kir5.1 subunit. These findings suggest that Kir5.1/Kir4.1 heteromeric channels are likely to exist in vivo and implicate an important and novel functional role for the Kir5.1 subunit.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Potássio
/
Canais de Potássio Corretores do Fluxo de Internalização
/
Concentração de Íons de Hidrogênio
/
Túbulos Renais
Limite:
Animals
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Reino Unido