Smart and biofunctional streptavidin.
Biomol Eng
; 16(1-4): 93-9, 1999 Dec 31.
Article
em En
| MEDLINE
| ID: mdl-10796990
ABSTRACT
The high affinity recognition of biotin and biotinylated molecules has made streptavidin one of the most important components in diagnostics and laboratory kits. While it is extremely useful as the native protein, there are many applications where its function can be improved re-engineering the subunits. We review here our efforts to construct streptavidin tetramers that have 'smart' recognition capabilities, and which display functional peptide sequences. These smart and biofunctional streptavidin derivatives can 'talk' to cells, and 'listen' to external signals which control capture and release of biotinylated molecules.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estreptavidina
Idioma:
En
Revista:
Biomol Eng
Assunto da revista:
BIOLOGIA MOLECULAR
/
ENGENHARIA BIOMEDICA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos