Aminoethylprolyl peptide nucleic acids (aepPNA): chiral PNA analogues that form highly stable DNA:aepPNA2 triplexes.
Org Lett
; 1(10): 1513-6, 1999 Nov 18.
Article
em En
| MEDLINE
| ID: mdl-10836017
ABSTRACT
[formula see text] The replacement of the glycyl component in the peptide nucleic acid (PNA) backbone by a prolyl unit bearing a nucleobase leads to the aminoethylprolyl (aep) PNAs, which are chiral and cationic. The homooligomeric aepPNA binds to complementary DNA sequences with high affinity and sequence specificity, forming highly stable triplexes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Ácidos Nucleicos Peptídicos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Índia